Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Short Description:

Chemical Name: Entecavir Monohydrate

CAS: 209216-23-9

Appearance: White or Almost White Crystalline Powder

Antiviral drug used in the treatment of Hepatitis B Infection

API High Quality, Commercial Production

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Product Detail

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Description:

Manufacturer Supply with High Purity and Stable Quality
Chemical Name: Entecavir Monohydrate
CAS: 209216-23-9
Used in the treatment of Hepatitis B Infection
API High Quality, Commercial Production

Chemical Properties:

Chemical Name	Entecavir Monohydrate
Synonyms	Entecavir Hydrate; 9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate
CAS Number	209216-23-9
CAT Number	RF-API79
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C12H17N5O4
Molecular Weight	295.3
Melting Point	>220℃
Density	1.81
Shipping Condition	Shipped Under Ambient Temperature
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White or Almost White Crystalline Powder
Solubility	Freely Soluble in Dimethylformamide, Slightly Soluble in Water, Ethanol and Methanol
Identification IR	Spectrum of the sample corresponds to that of reference standard
Identification HPLC	The retention time of the test sample corresponds to that of the reference standard
Water Content (by K.F)	5.5%~6.5%
Specific Optical Rotation	+24.0° to +30.0° (DMF: MeOH=1:1 C=1%) (on anhydrous substance)
Residue on Ignition	≤0.10%
Related Substances
Furoentecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Entecavir Related Compound A	≤0.10%
Any Unspecified Impurity	≤0.10%
Total Impurities	≤0.30%
Residual Solvents
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl Chloride	≤1000ppm
Benzyl Alcohol	≤1000ppm
Microbial Limit
Total Aerobic Counts	≤100cfu/g
Yeasts and Molds	≤10cfu/g
Escherichia Coli	Should Not Detected
Heavy Metals	≤10ppm
Assay	98.0%~102.0% (HPLC; on the anhydrous basis)
Particle Size	95% of the particles should be within 125um
Test Standard	Enterprise Standard; United States Pharmacopoeia (USP) Standard
Usage	Antiviral drug used in the treatment of Hepatitis B Infection

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

FAQ:

Application:

Entecavir Monohydrate (CAS 209216-23-9) is an oral antiviral drug used in the treatment of Hepatitis B Virus (HBV) infection. Entecavir Monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the vira. It is a new kind of cyclopentyl acyl guanosine anti-Hepatitis B virus drugs with its pharmacological effects similar as Entecavir. It is clinically applied to the treatment of adult Chronic Hepatitis B in which there is active viral replication, increased serum transaminase ALT or active lesions showed from liver histology. Entecavir Monohydrate is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. Entecavir is a reverse transcriptase inhibitor. It prevents the Hepatitis B Virus (HBV) from multiplying and reduces the amount of virus in the body.