Epalrestat CAS 82159-09-9 Purity >99.5% (HPLC) Factory

Short Description:

Chemical Name: Epalrestat 

CAS: 82159-09-9

Purity: >99.5% (HPLC)

Orange to Orange Red Crystalline Powder

Epalrestat is an Aldose Reductase Inhibitor, Used in the Treatment of Diabetic Neuropathy

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Epalrestat (CAS: 82159-09-9) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Epalrestat, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Epalrestat  
Synonyms Epalrest; ONO-2235; Eabeth; Kinedak; Sorbistat; (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-Thiazolidineacetic Acid; 2-[(5Z)-5-[(E)-3-Phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic Acid; (E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazolidin-3-yl]acetic Acid
Stock Status In Stock, Mass Production 
CAS Number 82159-09-9
Molecular Formula C15H13NO3S2
Molecular Weight 319.39 g/mol
Melting Point 222.0 to 226.0℃ 
Density 1.43±0.10 g/cm3 
Solubility  DMSO 2 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Storage Temp.  Cool & Dry Place (-20℃) 
COA & MSDS Available
Category   API  
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance Orange to Orange Red Crystalline Powder
Complies
Identification Identical to the HPLC retention time of standard Pass
Melting Point 222.0 to 226.0℃ 222.4~224.3℃
Loss on Drying <0.50% 0.04% 
Residue on Ignition <0.20% 0.03%
Heavy Metals (Pb) ≤20ppm <20ppm
Total Impurities  ≤0.50% 0.20%
Purity / Analysis Method >99.5% (HPLC)  99.8% 
Infrared Spectrum Conforms to Structure Complies      
Conclusion The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (-20℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

82159-09-9 - Risk and Safety:

UN IDs 2811
WGK Germany 3
RTECS XJ5131855
Hazard Class 6.1
Packing Group II

Application:

Epalrestat (CAS: 82159-09-9) is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. Epalrestat is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy. Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.
Epalrestat is used to prevent, ameliorate, and treat peripheral neuropathy (numbness, pain), vibrational paresthesia, and cardiac abnormality associated with diabetes.
Epalrestat as its representative drug reduces intracellular accumulation of fructose and sorbitol by reversibly inhibiting aldose reductase activity, restores Na+-K+-ATPase and inositol activity, increases NO formation in endothelial cells, inhibits protein kinase C signalling pathway, endothelial cell adhesion, high glucose-mediated neutrophil and endothelial adhesion factor expression and reduces carboxymethyl lysine products in diabetic patients, thus treating diseases such as diabetes and its complications. 

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