Ethyl 4-Hydroxybenzoate Ethylparaben CAS 120-47-8 Assay 98.0-102.0% Food Additives Preservatives

Short Description:

Chemical Name: Ethyl 4-Hydroxybenzoate

Synonyms: Ethylparaben 

CAS: 120-47-8

Assay: 98.0-102.0% 

Appearance: White Crystalline Powder

Food Additives, Preservatives, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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120-47-8 - Description:

Ruifu Chemical is the leading manufacturer of Ethyl 4-Hydroxybenzoate (Ethylparaben) (CAS: 120-47-8) with high quality, used as a food additive, preservative. Ruifu has been supplying Ethylparaben more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Ethylparaben or other products, please contact us by e-mail: alvin@ruifuchem.com

120-47-8 - Chemical Properties:

Chemical Name Ethyl 4-Hydroxybenzoate
Synonyms Ethylparaben; Ethyl-p-Hydroxybenzoate; 4-Hydroxybenzoic Acid Ethyl Ester; Easeptol
Stock Status In Stock, Commercial Production  
CAS Number 120-47-8
Molecular Formula C9H10O3
Molecular Weight 166.18 g/mol
Melting Point 115.0-118.0℃ 
Boiling Point 178℃/11 mmHg 
Sensitive Sensitive to Light  
Water Solubility  Insoluble in Water 
Solubility  Slightly Soluble in Chloroform
Storage Temperature Store Long-Term at 2-8℃
COA & MSDS Available
Sample  Available
Shelf Life 36 Months When Properly Stored
Origin of Product    Shanghai, China
Product Categories
Food Additives; Preservatives 
Brand Ruifu Chemical

120-47-8 - Specifications:

Items Specifications  Results
Appearance White Crystalline Powder    White Crystalline Powder  
Infrared Absorption  Conforms to Structure   Conforms 
Assay / Analysis Method 98.0-102.0%  99.55%
Color of Solution  Clear and Transparent (10% Ethanol Solution) Clear and Transparent
Acidity (pH) 4.0-7.0 4.56
Melting Point 115.0-118.0℃ 116.6-117.6℃
Water by Karl Fischer  ≤0.50% 0.31%
Residue on Ignition ≤0.10% 0.05%
Organic Volatile Impurities ≤0.50% Conforms 
p-Hydroxybenzoic Acid ≤0.50% Conforms 
Unspecified Impurities ≤0.50% Conforms 
Total Impurities ≤1.00% Conforms 
Chloride (Cl-)  ≤0.35% Conforms 
Sulfate (SO42-) ≤0.04% Conforms 
Heavy Metals (Pb) ≤0.001% <0.001%
Conclusion The product has been tested and complies with the given specifications

120-47-8 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery. 

120-47-8 - USP35 Standard:

Ethylparaben
C9H10O3 166.17
Benzoic acid, 4-hydroxy-, ethyl ester;
Ethyl p-hydroxybenzoate [120-47-8].
DEFINITION
Ethylparaben contains NLT 98.0% and NMT 102.0% of C9H10O3.
IDENTIFICATION
• A. Infrared Absorption <197M>
• B. Melting Range or Temperature <741>: 115-118℃
ASSAY
• Procedure
Mobile phase, Sample solution, Standard solution B, and Chromatographic system: Proceed as described in the procedure for Related Substances.
System suitability
Sample: Standard solution B
Suitability requirements
Relative standard deviation: NMT 0.85% for 6 injections
Analysis
Samples: Sample solution and Standard solution B
Calculate the percentage of Ethylparaben in the Sample solution:
Result = P × (rU × CS)/(rS × CU)
P = labeled purity of USP Ethylparaben RS expressed as a percentage
rU = peak area of ethylparaben from the Sample solution
CS = concentration of ethylparaben in Standard solution B
rS = peak area of ethylparaben from Standard solution B
CU = concentration of Ethylparaben in the Sample solution
Acceptance criteria: 98.0%-102.0%
IMPURITIES
Inorganic Impurities
• Residue on Ignition <281>: NMT 0.1%, determined on 1.0 g
Organic Impurities
• Procedure: Related Substances
Mobile phase: Methanol and a 6.8-g/L solution of potassium dihydrogen phosphate (65:35 v/v)
Sample solution: Dissolve 50.0 mg of Ethylparaben in 2.5 mL of methanol, and dilute with Mobile phase to 50.0 mL. Dilute 10.0 mL of this solution with Mobile phase to 100.0 mL.
Standard solution A: 5.0 µg/mL each of p-hydroxybenzoic acid, USP Methylparaben RS, and USP Ethylparaben RS in Mobile phase
Standard solution B: Dissolve 50.0 mg of USP Ethylparaben RS in 2.5 mL of methanol, and dilute with Mobile phase to 50.0 mL. Dilute 10.0 mL of this solution with Mobile phase to 100.0 mL.
Standard solution C: Dilute 1.0 mL of the Sample solution with Mobile phase to 20.0 mL. Dilute 1.0 mL of this solution with Mobile phase to 10.0 mL.
Chromatographic system
(See Chromatography <621>, System Suitability.)
Mode: LC
Detector: UV 272 nm
Column: 4.6-mm × 15-cm; 5-µm packing L1
Flow rate: 1.3 mL/min
Injection size: 10 µL
Run time: About 4 times the retention time of ethylparaben
System suitability
Sample: Standard solution A
[Note-The retention time of ethylparaben is about 3.0 min; the relative retention times for p-hydroxybenzoic acid, ethylparaben, and methylparaben are about 0.5, 1.0, and 0.8, respectively.]
Suitability requirements
Resolution: NLT 2.0 between the methylparaben and ethylparaben peaks
Analysis
Samples: Sample solution and Standard solution C
[Note-Disregard any limit that is 0.2 times the area of the principal peak in the chromatogram obtained with Standard solution C (0.1%).]
Acceptance criteria
p-Hydroxybenzoic acid: The peak area in the Sample solution, multiplied by 1.4 to correct for the calculation of content, is NMT the area of the principal peak in Standard solution C (0.5%).
Unspecified impurities: The peak area of each impurity in the Sample solution is NMT the area of the principal peak in Standard solution C (0.5%).
Total impurities: The total peak area for all impurities in the Sample solution is NMT twice the area of the principal peak in Standard solution C (1.0%).
SPECIFIC TESTS
• Color of Solution
Sample solution: 100 mg/mL in alcohol
Comparison solution: Mix 2.4 mL of ferric chloride CS, 1.0 mL of cobaltous chloride CS, and 0.4 mL of cupric sulfate CS with 0.3 N hydrochloric acid to make 10 mL. Dilute 5 mL of this solution with 0.3 N hydrochloric acid to make 100 mL. [Note-Prepare and use this solution immediately.]
Analysis
Samples: Alcohol, Sample solution, and Comparison solution
Make the comparison by viewing the solutions downward in matched color-comparison tubes against a white surface (see Color and Achromicity <631>).
Acceptance criteria: The Sample solution is clear and not more intensely colored than alcohol or the Comparison solution.
• Acidity
Sample solution: To 2 mL of Sample solution prepared in the test for Color of Solution, add 3 mL of alcohol, 5 mL of carbon dioxide-free water, and 0.1 mL of bromocresol green TS.
Analysis: Titrate with 0.10 N sodium hydroxide.
Acceptance criteria: NMT 0.1 mL is required to produce a blue color.
ADDITIONAL REQUIREMENTS
• Packaging and Storage: Preserve in well-closed containers.
• USP Reference Standards <11>
USP Ethylparaben RS
USP Methylparaben RS

120-47-8 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

120-47-8 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

120-47-8 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S24/25 - Avoid contact with skin and eyes.
WGK Germany 1
RTECS DH2190000
TSCA Yes
HS Code 2918290000
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

120-47-8 - Application:

Ethyl 4-Hydroxybenzoate (Ethylparaben) (CAS: 120-47-8) is used as a preservative and bacteriostatic agent for food, cosmetics, pharmaceuticals, feeds, leather and other industries; The antibacterial effect on fungi is strong, but the antibacterial effect on bacteria is weak. Used as a bacteriostatic preservative, widely used in liquid preparations and semi-solid preparations, can also be used for food and cosmetics antiseptic.
Ethylparaben is internationally recognized as a broad - spectrum high - efficiency food preservative, and a certain amount of preservative is added to cosmetics to prevent microorganisms from spoilage of cosmetics. Ethylparaben has a wide antibacterial effect on mold, yeast and bacteria, and has a strong effect on mold and yeast.

Ethylparaben is also used as an organic analytical reagent. 

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