Factory Supply Acetylacetone - 4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS 35144-22-0 Ambrisentan Intermediate High Quality – Ruifu

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Factory Supply Acetylacetone - 4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS 35144-22-0 Ambrisentan Intermediate High Quality – Ruifu Detail:

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Commercial Supply Ambrisentan (CAS: 177036-94-1) Related Intermediates:
3,3-Diphenyloxirane-2-carboxylic Acid Methyl Ester CAS: 76527-25-8
Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate CAS: 178306-47-3
2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(methylsulfonyl)pyrimidine CAS: 35144-22-0

Chemical Name 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
Abbreviation DLMSP
CAS Number 35144-22-0
CAT Number RF-PI164
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C7H10N2O2S
Molecular Weight 186.23
Solubility (Soluble in) Methanol
Brand Ruifu Chemical
Item Specifications
Appearance Yellow Crystalline Powder
Purity / Analysis Method ≥98.0% (HPLC)
Melting Point 80.0~84.0℃
Moisture (K.F) ≤0.50%
Test Standard Enterprise Standard
Usage Intermediate of Ambrisentan (CAS: 177036-94-1)

4,6-Dimethyl-2-(methylsulfonyl)pyrimidine (CAS: 35144-22-0) Synthetic Route

35144-22-0

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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4,6-Dimethyl-2-(methylsulfonyl)pyrimidine CAS 35144-22-0  Intermediate of Ambrisentan (CAS: 177036-94-1).

Ambrisentan (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.

Ambrisentan (CAS: 177036-94-1), (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof Ambrisentan (CAS: 177036-94-1) for once-daily treatment of PAH. Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.


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