Fondaparinux Sodium CAS 114870-03-0 API

Short Description:

Chemical Name: Fondaparinux Sodium

CAS: 114870-03-0

Appearance: White to Off-White Powder

Assay: 95.0%~103.0% (on Dried Basis)

An Antithrombotic Anticoagulant, a Factor Xa Inhibitor

Contact: Dr. Alvin Huang

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Product Detail

Product Tags

Description:

Supply with High Purity and Stable Quality
Chemical Name: Fondaparinux Sodium
CAS: 114870-03-0
An Antithrombotic Anticoagulant, a Factor Xa Inhibitor
API High Quality, Commercial Production

Chemical Properties:

Chemical Name	Fondaparinux Sodium
CAS Number	114870-03-0
CAT Number	RF-API84
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C31H43N3O49S8.10Na
Molecular Weight	1728.08
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Powder
Assay / Analysis Method	95.0%~103.0% (on dried basis)
Solubility	Freely Soluble in Water, 2.0M Sodium Chloride and 0.5M Sodium Hydroxide and Insoluble in Ethanol
Identification 13C-NMR	Resonances for Fondaparinux Sodium should be observed at 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7 and 178.0ppm. The Chemical shifts of these signals do not differ by more than ±0.3ppm other signals of variable heights and chemical shifts, attributable to Fondaparinux Sodium, maybe seen between 58.0~80.5 ppm and 98.7~104.5ppm
Identification HPLC	The retention time of the major peak of the sample solution corresponds to that of the standard solution
Identification AAS	Sodium should have characteristic absorption at 330.2nm under the determination of sodium
pH	6.0~8.0
Sodium (Na)	11.5%~15.0% (Calculated on anhydrous and solvents free)
Free Sulfate	≤0.30%
Residual Chloride	≤1.00%
Related Substances
Impurity A	≤0.80%
Impurity B	≤0.60%
Single Other Impurity	≤0.30%
Total Impurities	≤2.00%
Residual Solvents
Methanol	≤3000ppm
Ethanol	≤5000ppm
Ethyl Acetate	≤5000ppm
DMF	≤880ppm
Methylbenzene	≤890ppm
Pyridine	≤50ppm
Water Content (K.F)	≤15.0%
Bacterial Endotoxins	≤3.3EU/mg
Microbial Limit	The total number of Microorganisms ≤100cfu/g
Test Standard	Enterprise Standard; United States Pharmacopoeia (USP) Standard
Usage	API, An Antithrombotic Anticoagulant, a Factor Xa Inhibitor

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

FAQ:

Application:

Fondaparinux Sodium (CAS 114870-03-0) is the first of a new class of an antithrombotic anticoagulant chemically related to low molecular weight heparins (LMWH). Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). Fondaparinux sodium binding at this site potentiates the natural inhibitory effect of ATIII against factor Xa by a factor of approximately 300, which results in inhibition of thrombin generation. It is marketed by GlaxoSmithKline. A generic version developed by Alchemia is marketed within the US by Dr. Reddy's Laboratories. Fondaparinux sodium was first introduced in the US for prophylaxis of deep vein thrombosis which may lead to pulmonary embolism following major orthopaedic surgery. This entirely synthetic molecule is a copy of the heparin pentasaccharide sequence, the shortest fragment able to catalyze antithrombin lllmediated inhibition of factor Xa thereby inhibiting thrombin generation without antithrombin action.