2-Methyltryptamine CAS 2731-06-8 Purity > 99.0% (HPLC) Panobinostat Eadar-mheadhanach Factaraidh Àrd chàileachd
Solaraiche Dèanadair le Riochdachadh Malairteach de chàileachd àrd
Ainm Ceimigeach: 2-Methyltryptamine CAS: 2731-06-8
Ainm Ceimigeach | 2-Methyltryptamine |
Co-fhaclan | 2-Methylindole-3-Ethylamine;2-(2-Methyl-1H-indol-3-yl)ethanamine;3-(2-Aminoethyl)-2-Methylindole |
Àireamh CAS | 2731-06-8 |
Àireamh CAT | RF-PI1480 |
Inbhe Stoc | Ann an stoc, ìre toraidh suas gu tonna |
Foirmle Molecular | C11H14N2 |
Cuideam Molecular | 174.25 |
Rubha leaghaidh | 106.0 gu 110.0 ℃ |
Rubha Goil | 177 ℃ / 1.5mmHg (lit.) |
Brand | Ceimigeach Ruifu |
Nì | Sònrachaidhean |
Coltas | Donn Soladach |
Purity / Modh Mion-sgrùdadh | > 99.0% (Sgìre HPLC) |
1-HNMR | Co-chòrdail ri Structar |
Call air tiormachadh | <1.00% |
Impurity singilte | <0.50% |
Neo-dhìomhaireachd iomlan | <1.00% |
Meatailtean Trom (mar Pb) | <20ppm |
Inbhe deuchainn | Inbhe Iomairt |
Cleachdadh | Cungaidhean-leigheis eadar-mheadhanach;Panobinostat eadar-mheadhanach |
Pacaid: Botal, poca foil alùmanum, 25kg / druma cairt-bhòrd, no a rèir riatanas luchd-ceannach.
Suidheachadh stòraidh:Bùth ann an soithichean dùinte ann an àite fionnar is tioram;Dìon bho sholas is taiseachd.
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Tha 2-Methyltryptamine (CAS: 2731-06-8) na phrìomh stuth tòiseachaidh ann an synthesis Panobinostat (LBH589) (CAS: 404950-80-7).Tha Panobinostat na neach-dìon làidir de gach deacetylases histone (HDACn), le luachan Ki eadar 0.6 agus 31 nM airson HDAC1-11.Tron ghnìomh seo, bidh e a’ leantainn gu acetylation de raon de phròtainean cealla, a’ leantainn gu grèim cearcall cealla agus apoptosis ann an ceallan aillse.Is e Panobinostat a’ chiad neach-dìon HDAC a chaidh aontachadh le FDA airson làimhseachadh myeloma iomadach.Tha Panobinostat air a mhargaidheachd mar Farydak, air a chleachdadh ann an co-bhonn le Bortezomib (CAS: 179324-69-7) agus Dexamethasone (CAS: 50-02-2) gus làimhseachadh myeloma iomadach ath-chraoladh às deidh làimhseachadh ro-làimh le Bortezomib agus immunomodulator.
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