7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3 Irinotecan Hydrochloride Eadar-mheadhanach Àrd Purity
Solaraiche Solaraiche Irinotecan agus Eadar-mheadhanan Co-cheangailte:
Irinotecan Hydrochloride CAS: 100286-90-6
Bunait an-asgaidh Irinotecan CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
Ainm Ceimigeach | 7-Ethyl-10-Hydroxycamptothecin |
Co-fhaclan | SN-38 |
Àireamh CAS | 86639-52-3 |
Àireamh CAT | RF-PI242 |
Inbhe Stoc | Ann an stoc, ìre toraidh suas gu tonna |
Foirmle Molecular | C22H20N2O5 |
Cuideam Molecular | 392.41 |
Brand | Ceimigeach Ruifu |
Nì | Sònrachaidhean |
Coltas | Pùdar criostalan geal aotrom buidhe |
Aithneachadh (IR, UV) | (1) Tha speactram gabhail a-steach ghathan ultraviolet a rèir na h-iarrtasan (2) Bidh speactram gabhail a-steach ghathan fo-dhearg a tha co-chosmhail ri speactram àbhaisteach iomraidh a’ cumail ri deuchainnean ceadaichte |
Rubha leaghaidh | 228.0 ~ 235.0 ℃ |
Stuthan Co-cheangailte | ≤1.5% |
10-Hydroxycamptothecin | ≤0.30% |
7-Cthylcamptothecin | ≤0.70% |
Impurity Neo-aithnichte as àirde | ≤0.50% |
Call air tiormachadh | ≤1.0% |
Meatailtean Trom | ≤10 ppm |
Fuigheall air Ignition | ≤0.10% |
Soilleireachd Fuasglaidh | Soilleir |
Assay | ≥98.0% (HPLC) |
Inbhe deuchainn | Inbhe Iomairt |
Cleachdadh | Cungaidh-leigheis eadar-mheadhanach de Irinotecan |
Pacaid: Botal, poca foil alùmanum, druma cairt-bhòrd, 25kg / Drum, no a rèir riatanas luchd-ceannach.
Suidheachadh stòraidh:Bùth ann an soithichean dùinte ann an àite fionnar is tioram;Dìon bho sholas, taiseachd agus plàighean.
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Is e Shanghai Ruifu Chemical Co., Earr am prìomh neach-dèanamh agus solaraiche de 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) le càileachd àrd.Tha 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) na mheatabolite gnìomhach den inhibitor Topoisomerase I Irinotecan.Tha SN-38 (NK012) a’ bacadh synthesis DNA agus RNA le IC50s de 0.077 agus 1.3 μM, fa leth.Is e 7-Ethyl-10-Hydroxycamptothecin (SN-38), am metabolite gnìomhach de Irinotecan, toradh semisynthetic de camptothecin, alkaloid stèidhichte air quinoline a lorgar ann an rùsg craobh camptotheca Sìneach agus craobh nothapodytes Àisianach.Ged a tha 7-Ethyl-10-Hydroxycamptothecin suas ri 1,000 uair nas cumhachdaiche na Irinotecan, cha deach a thionndadh gu bhith na thagraiche dhrogaichean obrachail leis gu bheil e do-fhuasgladh.Thathas an-dràsta a’ dol tro dheuchainnean clionaigeach an co-bhonn ri buidhnean eile a dh’ fhaodadh leigeil leis a bhith èifeachdach mar dhroga antineoplastic.