Imatinib Mesylate CAS 220127-57-1 Assay 98.0% ~ 102.0% Ph + CML API Factory Càileachd Àrd
Solarachadh Malairteach Imatinib Mesylate agus Meadhanan Co-cheangailte:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] searbhag benzoic dihydrochloride CAS: 106261-49-8
| Ainm Ceimigeach | Imatinib Mesylate (cruth alpha) |
| Co-fhaclan | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Àireamh CAS | 220127-57-1 |
| Àireamh CAT | RF-API19 |
| Inbhe Stoc | Ann an stoc, ìre toraidh suas gu tonna |
| Foirmle Molecular | C30H35N7O4S |
| Cuideam Molecular | 589.71 |
| Suidheachadh luingeis | Fo Teòthachd Àrainneachdail |
| Brand | Ceimigeach Ruifu |
| Nì | Sònrachaidhean |
| Coltas | Pùdar criostalach geal gu neo-gheal |
| Fuasgladh | Furasta a sgaoileadh san uisge |
| Aithneachadh HPLC | Bidh sampall ùine gleidhidh prìomh stùc speactram a rèir sin |
| Aithneachadh IR | Tha speactram in-ghabhail fo-dhearg den sampall a rèir sampall iomraidh |
| Rubha leaghaidh | 214.0 ~ 222.0 ℃ |
| Call air tiormachadh | ≤0.50% |
| Fuigheall air Ignition | ≤0.10% |
| Meatailtean Trom | ≤20ppm |
| Stuthan Co-cheangailte | (1) Impurity G: NMT 0.3% |
| (2) Impurity B: NMT 0.3% | |
| (3) Impurity C: NMT 0.3% | |
| (4) Impurity D: NMT 0.3% | |
| (5) Impurity A: NMT 0.3% | |
| (6) Impurity H: NMT 0.3% | |
| (7) Impurity F: NMT 0.3% | |
| (8) Impurity E: NMT 0.3% | |
| (9) An neo-chunbhalachd singilte as motha: NMT0.1% | |
| Fuasglaidhean air fhàgail | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Measadh HPLC | 98.0% ~ 102.0% (C30H35N7SO4 air a thomhas air bunait anhydrous) |
| Inbhe deuchainn | Inbhe Iomairt |
| Cleachdadh | API;Ph+CML |
Pacaid: Botal, poca foil alùmanum, druma cairt-bhòrd, 25kg / Drum, no a rèir riatanas luchd-ceannach.
Suidheachadh stòraidh:Bùth ann an soithichean dùinte ann an àite fionnar is tioram;Dìon bho sholas, taiseachd agus plàighean.
Tha Imatinib Mesylate (CAS 220127-57-1) na mholacile beag a tha a’ bacadh an c-Abl protein-tyrosine kinase, kinase a tha gu sònraichte cudromach airson iomadachadh leucemia myelogenous cronach (CML).Gu math sònraichte airson BCR-ABL, an enzyme a tha co-cheangailte ri leucemia myelogenous cronach (CML) agus cruthan sònraichte de leucemia lymphoblastic acute (ALL).Tha e na neach-dìon v-Abl tyrosine kinase cumhachdach agus roghnach (IC50 = 38 nM).Bidh tachartas tar-chuir eadar cromosomes 9 agus 22 a ’gineadh cromosome Philadelphia, a bhios an uairsin a’ toirt a-mach pròtain fusion Bcr-Abl le gnìomhachd aberrant kinase a bhrosnaicheas iomadachadh cealla luath.Bidh Imatinib mesylate a’ ceangal an kinase deatamach seo, a’ cur stad air fàs co-cheangailte ri CML.Chaidh Imatinib mesylate a thaisbeanadh tuilleadh gus casg a chuir air PDGFR agus tyrosine kinases co-cheangailte ri c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl] searbhag benzoic dihydrochloride CAS 106261-49-8 Imatinib Mesylate Eadar-mheadhanach Àrd Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)