Imatinib Mesylate CAS 220127-57-1 Assay 98.0% ~ 102.0% Ph + CML API Factory Càileachd Àrd
Solarachadh Malairteach Imatinib Mesylate agus Meadhanan Co-cheangailte:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] searbhag benzoic dihydrochloride CAS: 106261-49-8
Ainm Ceimigeach | Imatinib Mesylate (cruth alpha) |
Co-fhaclan | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
Àireamh CAS | 220127-57-1 |
Àireamh CAT | RF-API19 |
Inbhe Stoc | Ann an stoc, ìre toraidh suas gu tonna |
Foirmle Molecular | C30H35N7O4S |
Cuideam Molecular | 589.71 |
Suidheachadh luingeis | Fo Teòthachd Àrainneachdail |
Brand | Ceimigeach Ruifu |
Nì | Sònrachaidhean |
Coltas | Pùdar criostalach geal gu neo-gheal |
Fuasgladh | Furasta a sgaoileadh san uisge |
Aithneachadh HPLC | Bidh sampall ùine gleidhidh prìomh stùc speactram a rèir sin |
Aithneachadh IR | Tha speactram in-ghabhail fo-dhearg den sampall a rèir sampall iomraidh |
Rubha leaghaidh | 214.0 ~ 222.0 ℃ |
Call air tiormachadh | ≤0.50% |
Fuigheall air Ignition | ≤0.10% |
Meatailtean Trom | ≤20ppm |
Stuthan Co-cheangailte | (1) Impurity G: NMT 0.3% |
(2) Impurity B: NMT 0.3% | |
(3) Impurity C: NMT 0.3% | |
(4) Impurity D: NMT 0.3% | |
(5) Impurity A: NMT 0.3% | |
(6) Impurity H: NMT 0.3% | |
(7) Impurity F: NMT 0.3% | |
(8) Impurity E: NMT 0.3% | |
(9) An neo-chunbhalachd singilte as motha: NMT0.1% | |
Fuasglaidhean air fhàgail | (1) Ethyl Acetate: NMT 5000ppm |
(2) Methanol: NMT3000ppm | |
(3) Dichloromethane: NMT 600ppm | |
(4) Ethanol: NMT 5000ppm | |
(5) Toluene: NMT 890ppm | |
(6) Dimethyl Sulfoxide: NMT5000ppm | |
Measadh HPLC | 98.0% ~ 102.0% (C30H35N7SO4 air a thomhas air bunait anhydrous) |
Inbhe deuchainn | Inbhe Iomairt |
Cleachdadh | API;Ph+CML |
Pacaid: Botal, poca foil alùmanum, druma cairt-bhòrd, 25kg / Drum, no a rèir riatanas luchd-ceannach.
Suidheachadh stòraidh:Bùth ann an soithichean dùinte ann an àite fionnar is tioram;Dìon bho sholas, taiseachd agus plàighean.
![1](https://a395.goodao.net/uploads/15.jpg)
![](https://a395.goodao.net/uploads/23.jpg)
Tha Imatinib Mesylate (CAS 220127-57-1) na mholacile beag a tha a’ bacadh an c-Abl protein-tyrosine kinase, kinase a tha gu sònraichte cudromach airson iomadachadh leucemia myelogenous cronach (CML).Gu math sònraichte airson BCR-ABL, an enzyme a tha co-cheangailte ri leucemia myelogenous cronach (CML) agus cruthan sònraichte de leucemia lymphoblastic acute (ALL).Tha e na neach-dìon v-Abl tyrosine kinase cumhachdach agus roghnach (IC50 = 38 nM).Bidh tachartas tar-chuir eadar cromosomes 9 agus 22 a ’gineadh cromosome Philadelphia, a bhios an uairsin a’ toirt a-mach pròtain fusion Bcr-Abl le gnìomhachd aberrant kinase a bhrosnaicheas iomadachadh cealla luath.Bidh Imatinib mesylate a’ ceangal an kinase deatamach seo, a’ cur stad air fàs co-cheangailte ri CML.Chaidh Imatinib mesylate a thaisbeanadh tuilleadh gus casg a chuir air PDGFR agus tyrosine kinases co-cheangailte ri c-Kit.