N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity > 99.0% (HPLC) Factaraidh eadar-mheadhanach Afatinib Dimaleate

Tuairisgeul goirid:

Ainm Ceimigeach: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Purity: > 99.0% (HPLC)

Coltas: Buidhe aotrom gu pùdar Buidhe

Eadar-mheadhanach de Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Cuir post-d thugainn

Mion-fhiosrachadh toraidh

Bathar Co-cheangailte

Bathar Tags

Tuairisgeul:

Solarachadh ceimigeach Ruifu eadar-mheadhanach de Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S) -(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
tar-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Acid Dietylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -aon CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S) -N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Feartan ceimigeach:

Ainm Ceimigeach	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Co-fhaclan	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Eadar-mheadhanach Afatinib A
Àireamh CAS	162012-67-1
Àireamh CAT	RF-PI2026
Inbhe Stoc	Ann an stoc, ìre toraidh suas gu tonna
Foirmle Molecular	C14H7ClF2N4O2
Cuideam Molecular	336.68
Cugallachd	Mothachadh Adhair, Mothachadh Teas
Rubha leaghaidh	242.0 ~ 244.0 ℃
Rubha Goil	489 ℃
Dùmhlachd	1.616
Brand	Ceimigeach Ruifu

Sònrachaidhean:

Nì	Sònrachaidhean
Coltas	Buidhe aotrom gu Pùdar Buidhe
Purity / Modh Mion-sgrùdadh	> 99.0% (HPLC)
Call air tiormachadh	<0.50%
Fuigheall air Ignition	<0.20%
Stuthan Co-cheangailte
Impurity fa leth	<0.50%
Impurities iomlan	<1.00%
Meatailtean Trom	≤20ppm
Spectrum fo-dhearg	A 'gèilleadh ris an Structar
Spectrum Proton NMR	A 'gèilleadh ris an Structar
Inbhe deuchainn	Inbhe Iomairt
Cleachdadh	Eadar-mheadhanach de Afatinib Dimaleate (CAS: 850140-73-7)

Pacaid & Stòradh:

Pacaid: Botal, poca foil alùmanum, 25kg / druma cairt-bhòrd, no a rèir riatanas luchd-ceannach

Suidheachadh stòraidh:Bùth ann an soithichean dùinte ann an àite fionnar is tioram;Dìon bho sholas is taiseachd

Buannachdan:

Ceistean Cumanta:

Iarrtas:

Tha N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) na eadar-mheadhanach ann an synthesis Afatinib Dimaleate (CAS: 850140-73-7) .Is e cruth salainn de Afatinib a th’ ann an Afatinib Dimaleate.Tha Afatinib na neach-dìon dàrna ginealach, air a rianachd gu beòil, nach gabh a thoirt air ais de theaghlach ErbB de tyrosine kinases.Bidh uidheamachd GnìomhAfatinib a ’lughdachadh comharran ErbB le bhith a’ ceangal gu covalently ri raointean kinase de receptor factar fàis epidermal (EGFR), receptor factar fàis epidermal daonna (HER) 2 agus HER4, a ’leantainn gu casg neo-atharrachail air autophosphorylation tyrosine kinase;bidh e cuideachd a’ bacadh transphosphorylation de HER3.Tha Afatinib air aontachadh mar monotherapy airson làimhseachadh EGFR tyrosine kinase inhibitor (TKI) - inbhich naive le adhartach gu h-ionadail no DefinitionChEBI: Salann maleate a gheibhear le bhith a ’cothlamadh afatinib le dà cho-ionann molar de dh’ searbhag maleic.Air a chleachdadh airson làimhseachadh ciad loidhne air euslaintich le aillse sgamhain meatastatach neo-bheag.