(R) -(+)-2-Methyl-CBS-oxazaborolidine;(R) -Me-CBS Catalyst CAS 112022-83-0 Optical Purity ≥98.0%

Solaraiche Dèanadair;Càileachd àrd agus prìs farpaiseach

Catalysts CBS
(S) -(-)-2-Methyl-CBS-oxazaborolidine;(S) -Me-CBS Catalyst (ca. 1mol/L ann an Toluene);CAS: 112022-81-8
(R) -(+)-2-Methyl-CBS-oxazaborolidine;(R) -Me-CBS Catalyst (ca. 1mol/L ann an Toluene);CAS: 112022-83-0

Catalyst CBS
Tha catalyst CBS no catalyst Corey-Bakshi-Shibata na inneal neo-chunbhalach a thàinig bho proline.Bidh e a’ lorg iomadh feum ann an ath-bheachdan organach leithid lughdachadh CBS, ath-bheachdan Diels-Alder agus (3 + 2) cycloadditions.Tha Proline, todhar chiral a tha a’ nochdadh gu nàdarra, ri fhaighinn gu furasta agus gu saor.Bidh e a’ gluasad an stereocenter aige chun inneal-brosnachaidh a bhios an uair sin comasach air ath-bhualadh organach a ghluasad gu roghnach gu aon de dhà enantiomers a dh’ fhaodadh a bhith ann.Tha an roghainn seo mar thoradh air cuideam steric anns an t-suidheachadh gluasaid a bhios a’ leasachadh airson aon enantiomer ach chan ann airson an tè eile.

Catalysts CBS airson Lùghdachadh Neo-chunbhalach agus Synthesis Neo-chunbhalach
Chaidh an catalyst oxazabolidine CBS (Corey-Bakshi-Shibata) a chleachdadh ann an lughdachadh neo-chunbhalach de ketones prochiral.Tha tagraidhean eile a’ toirt a-steach synthesis enantioselective de α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols, agus propargyl alcohols.

(R) - (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol / L ann an Toluene) CAS: 112022-83-0 faodar a chleachdadh mar inneal-brosnachaidh ann an lùghdachadh neo-chunbhalach borane de perfluoroalkyl ketones.Tha tagraidhean eile a’ toirt a-steach synthesis enantioselective de α-hydroxy acids, α-amino acids, C2 co-chothromach ferrocenyl diols, agus propargyl alcohols.Tha e cuideachd air a chleachdadh ann an lùghdachadh desymmetrizing leantainn gu (S) -4-hydroxycyclohexenone.Tha e feumail ann a bhith a 'dèanamh motifan stereospecific leithid α-hydroxy acids, α-amino acids, ferrocenyl diols co-chothromach agus alcohols propargyl.

(R) - (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol / L ann an Toluene) CAS: 112022-83-0 na inneal-catharra organoboron a thathas a’ cleachdadh ann an synthesis organach.Tha an catalyst seo, air a leasachadh le Itsuno agus Elias James Corey, air a chruthachadh le teasachadh (R) - (+) -2- (diphenylhydroxymethyl) pyrrolidine còmhla ri trimethylboroxine no searbhag methylboronic.Tha e na inneal sàr-mhath airson synthesis alcohols ann an co-mheas àrd enantiomeric.San fharsaingeachd, thathas a’ cleachdadh 2-10 mol% den inneal-brosnachaidh seo còmhla ri borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N, N-diethylaniline, no diborane mar an stòr borane.Lùghdachadh enantioselective a’ cleachdadh catalysts chiral oxazaborolidine air a chleachdadh ann an synthesis dhrogaichean malairteach leithid ezetimibe agus aprepitant.