Glimepiride CAS 93479-97-1 Assay 98.0%~102.0% API Factory High Purity

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Glimepiride (CAS: 93479-97-1) with high quality, active pharmaceutical ingredient (API). Glimepiride is an antidiabetic drug that helps control blood sugar levels. Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity.

Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin from functioning pancreatic beta cells and by increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. Glimepiride is mainly used to treat patients with type 2 diabetes and can also decrease the chances that someone will develop complications of type 2 diabetes. The drug was approved by the FDA in 1995 and is manufactured by Sanofi-Aventis. It can be used along with proper diet and exercise program and may also be used alone or with other antidiabetic medicines if need. Glimepiride can be used either as a monotherapy or in combination with insulin.