H-D-Trp-OMe·HCl CAS 14907-27-8 D-Tryptophan Methyl Ester Hydrochloride Purity >99.0% (HPLC)

Short Description:

D-Tryptophan Methyl Ester Hydrochloride

Synonyms: H-D-Trp-OMe·HCl

CAS: 14907-27-8

Assay: >99.0% (HPLC)

Appearance: White to Off-White Powder

Amino Acids Derivatives, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of D-Tryptophan Methyl Ester Hydrochloride (H-D-Trp-OMe·HCl) (CAS: 14907-27-8) with high quality. Ruifu Chemical supplys amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase H-D-Trp-OMe·HCl, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	D-Tryptophan Methyl Ester Hydrochloride
Synonyms	H-D-Trp-OMe·HCl; Methyl D-Tryptophanate Hydrochloride; (R)-Tryptophan Methyl Ester Monohydrochloride; (R)-Tryptophane Methyl Ester Hydrochloride
Stock Status	In Stock
CAS Number	14907-27-8
Molecular Formula	C12H14N2O2·HCl
Molecular Weight	254.71 g/mol
Melting Point	210.0~220.0℃
Density	1.337g/cm3 at 20℃
Solubility	Soluble in Methanol
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Amino Acids Derivatives
Brand	Ruifu Chemical

Safety Information:

Safety Statements	24/25	WGK Germany	3
HS Code	2922491990

Specifications:

Items	Inspection Standards	Results
Appearance	White to Off-White Powder	White Powder
Specific Rotation [α]20/D	-18.0°±2.0° (C=5 in MeOH)	-18.3°
TLC Analysis	≥99.0%	>99.0%
Melting Point	210.0~220.0℃	213.0~216.0℃
Loss on Drying	<0.50%	0.20%
Residue on Ignition	<0.20%	0.07%
Heavy Metals (Pb)	≤20ppm	<20ppm
Assay / Analysis Method	>99.0% (HPLC)	99.5%
Clarity of Solution	0.3 gram in 2ml H2O Clear Solution	Complies
Mass Spectrum	In Accordance With the Standard	Complies
NMR Spectrum	In Accordance With the Standard	Complies
Conclusion	This Product by Inspection Accords with the Enterprise Standard

Package & Storage:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

D-Tryptophan Methyl Ester Hydrochloride (H-D-Trp-OMe·HCl) (CAS: 14907-27-8) is an intermediate in the synthesis of Tryptophan derivatives; Useful as an intermediate in the drug substance Tadalafil (CAS: 171596-29-5) for the treatment of male erectile dysfunction; An intermediate of Tadalafil. Tadalafil was marketed in the United States in December 2003 as a daily oral dosage form. It is also approved in the United States and Europe for benign prostatic hyperplasia and pulmonary hypertension.
Amino acids derivatives, used in peptide synthesis, organic synthesis intermediates, pharmaceutical intermediates, biochemical reagents, chemical reagents.
Preparation of D-Tryptophan Methyl Ester Hydrochloride: D-Tryptophan (50g) is added to the mixed solution of toluene (650ml) and methanol (105ml) and stirred evenly, slowly dropwise addition of thionyl chloride (38.6g) at 0 degrees Celsius, after the dropwise addition, the temperature is raised to 75-80 degrees Celsius for 4 hours, the reaction is over, the reaction liquid is cooled to 0 degrees, the solid was precipitated, filtered, the filter cake was washed with toluene, and dried in vacuum at 50℃ for 6h to obtain D-Tryptophan Methyl Ester Hydrochloride. The yield was 95% and the HPLC purity was 99%.