H-Glu(OBzl)-NCA CAS 3190-71-4 Purity >98.0% (HPLC) Glatiramer Acetate Intermediate

Short Description:

5-Benzyl L-Glutamate N-Carboxyanhydride

Synonyms: H-Glu(OBzl)-NCA

CAS: 3190-71-4

Purity: >98.0% (HPLC)

Appearance: White to Off-White Powder

Amino Acids & Derivatives, High Quality

Intermediate of Glatiramer Acetate (CAS: 147245-92-9)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 5-Benzyl L-Glutamate N-Carboxyanhydride (H-Glu(OBzl)-NCA) (CAS: 3190-71-4) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. If you need H-Glu(OBzl)-NCA, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	5-Benzyl L-Glutamate N-Carboxyanhydride
Synonyms	H-Glu(OBzl)-NCA; L-Glu(OBzl)-NCA; (S)-Benzyl 3-(2,5-Dioxooxazolidin-4-yl)propanoate; Benzyl (S)-3-(2,5-Dioxooxazolidin-4-yl)propanoate; (4S)-2,5-Dioxo-4-Oxazolidinepropanoic Acid Phenylmethyl Ester; (+)-(S)-Glutamic Acid γ-Benzyl Ester N-Carboxyanhydride; L-Glutamic Acid-γ-Benzyll ester N-Carboxyanhydride; L-γ-Benzylglutamic Acid Carboxyanhydride; γ-Benzyl N-carboxy-L-Glutamic Anhydride; 5-Benzyl Glutamic Acid Ester NCA
Stock Status	In Stock
CAS Number	3190-71-4
Molecular Formula	C13H13NO5
Molecular Weight	263.25 g/mol
Melting Point	85.0~95.0℃
Density	1.293 g/cm3
Refractive Index	1.54
Sensitive	Air Sensitive, Heat Sensitive
COA & MSDS	Available
Classification	Amino Acids & Derivatives
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White to Off-White Powder	Off-White Powder
Identification Methods	HNMR / HPLC	Conforms
Melting Point	85.0~95.0℃	87.3~88.5°C
Purity / Analysis Method	>98.0% (HPLC)	98.5%
Specific Rotation [α]20/D	-14.0° ± 2.0° (C=1, THF)	-14.7°
Loss on Drying	<0.50%	0.25%
Conclusion	This Product by Inspection Accords with the Enterprise Standard
Main Uses	Pharmaceutical Intermediates; Glatiramer Acetate Intermediate

Package & Storage:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

5-Benzyl L-Glutamate N-Carboxyanhydride (H-Glu(OBzl)-NCA) (CAS: 3190-71-4) is used as the pharmaceutical intermediates. H-Glu(OBzl)-NCA can be used as an intermediate of Glatiramer Acetate (CAS: 147245-92-9). Glatiramer Acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis. 5-Benzyl L-Glutamate N-Carboxyanhydride is a reactive derivative of L-glutamic acid, where the amino acid has been cyclised as an N-carboxyanhydride (NCA), a class of reagent known as Leuchs’ anhydrides. 5-Benzyl L-Glutamate N-Carboxyanhydride reacts with nucleophiles such as alcohols and amines to form esters and amides respectively. The opening of the N-carboxyanhydride to an ester or amide releases the amino acid amine which can also react as a nucleophile leading to polymerisation. These poly-amide polymers have been investigated as delivery platforms of Small Interfering RNA (si-RNA).