H-Glu(OtBu)-OH CAS 2419-56-9 Purity >98.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of H-Glu(OtBu)-OH (CAS: 2419-56-9) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase H-Glu(OtBu)-OH, Please contact: alvin@ruifuchem.com
| Chemical Name | L-Glutamic Acid 5-tert-Butyl Ester |
| Synonyms | H-Glu(OtBu)-OH; L-Glu(OtBu)-OH; L-Glutamic Acid γ-tert-Butyl Ester; 5-tert-Butyl L-Glutamate; (2S)-2-Amino-5-tert-Butoxy-5-Oxopentanoic Acid; (S)-2-Amino-5-tert-Butoxy-5-Oxopentanoic Acid |
| Stock Status | In Stock |
| CAS Number | 2419-56-9 |
| Molecular Formula | C9H17NO4 |
| Molecular Weight | 203.24 g/mol |
| Melting Point | 182℃(lit.) |
| Density | 0.992 g/cm3 |
| Sensitive | Heat Sensitive |
| Solubility | Sparingly Soluble in Water; Practically Insoluble in Ethanol or Ether |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Amino Acids and Derivatives |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | White Powder | White Powder |
| Specific Rotation [α]20/D | +19.0°±2.0° (C=1 in AcOH) |
+20.4° |
| Melting Point | ~170.0℃ | 171.2~171.8℃ |
| TLC | ≥98.0% | >98.0% |
| Element Analysis (C、H、N) | ≤5.0% | <5.0% |
| Clarity of Solution | 0.3 gram in 2ml AcOH Clear Solution | Complies |
| Water Content (K.F.) | ≤6.00% | 1.25% |
| Loss on Drying | ≤5.00% (70°C, 2h) | 0.48% |
| Purity / Analysis Method | >98.0% (HPLC) | 99.12% |
| Mass Spectrum | In Accordance With the Standard | Complies |
| NMR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Heat sensitive. Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from heat, light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
R22 - Harmful if swallowed
R24 - Toxic in contact with skin
Safety Description
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S25 - Avoid contact with eyes.
WGK Germany 3
HS Code 2922491990
Hazard Class IRRITANT
L-Glutamic Acid 5-tert-Butyl Ester (H-Glu(OtBu)-OH) (CAS: 2419-56-9) is a glutamic acid derivative, can be obtained by the reaction of glutamic acid and tert-butyl acetate.
Amino acids and derivatives, used in peptide synthesis, organic synthesis intermediates, pharmaceutical intermediates, biochemical reagents, chemical reagents.
Preparation add 2324g of tert-butyl acetate and 73.5g of glutamic acid into a 3000mL three-mouth bottle, stir, drop 160.8mL of perchloric acid, react at 10℃ for 48 hours, cool to 0℃, add 1000mL of water, extract take (the remaining tert-butyl acetate is extracted as solvent), neutralize with Na2CO3 to pH = 8~9, separate the liquid, then wash with 400 mL1% Na2CO3 aqueous solution three times, and concentrate the tert-butyl acetate layer under reduced pressure to obtain 42g of oil Glu(OtBu)2 with a yield of 32.4%. Add 42g of Glu(OtBu)2 into a 1000mL three-mouth bottle, then add 400mL of water and 11g of CuCl2, raise the temperature to 50℃, react for 12 hours, and prepare Cu[Glu(OtBu)]x(x = 1~2); When it is reduced to room temperature, add 19g of tetramethylethylenediamine and 100mL of dioxane, and then adjust the pH to 8~9 with triethylamine, L-Glutamic Acid 5-tert-Butyl Ester was prepared.
