1-Methyl-3-Pyrrolidinol CAS 13220-33-2 Tsaftace>98.0% (GC)

Ƙara 1,2,4-Butanetriol da glacial acetic acid zuwa tukunyar amsawa, motsawa da zafi zuwa kimanin 100 ℃, ƙara busassun iskar hydrogen chloride, kuma amsa a 90 ~ 110 ℃ na 30h, lokacin da babban adadin hydrogen chloride ya fara. ya bayyana a cikin iskar wutsiya, an duba ƙarshen abin da ya faru kuma an dakatar da hydrogen chloride.Bayan sanyaya, kayan da aka saki, wanke tare da cikakken sodium carbonate bayani, da kuma hõre distillation a karkashin rage matsa lamba, da kuma 120 zuwa 135 ℃.(12.6 zuwa 13. 3kPa) juzu'i, I.e., 1,4-Dichloro-2-Butanol mai mai, samar da 50% ~ 60%.
Cyclization wani bayani mai ruwa na 1,4-Dichloro-2-Butanol da Methylamine an ƙara shi a cikin tukunyar cyclization, kuma ya zafi zuwa 120 ℃.A ƙarƙashin rufaffiyar dumama, kuma an motsa abin da aka yi don 10h.Bayan an sanyaya, an ƙara daɗaɗɗen sodium hydroxide, kuma an cire gishirin da ba a haɗa shi ba.The man Layer aka rabu da hõre injin distillation, da kuma juzu'i na 76-85 ℃.(2.1 kPa) an tattara shi don zama samfurin da aka gama.Cire Layer mai ruwa tare da benzene shima yana haifar da wani yanki na 1-Methyl-3-Pyrrolidinol.Yawan amfanin ya kai kusan 60%.
3. Mahimman matakai:
3.1 Tsarin amsawa da aka maye gurbin: sarrafa lokacin amsawa kuma gano ƙarshen lokacin amsawa
3.2 Vacuum distillation tsari na 1,4-Dichloro-2-Butanol: sarrafa injin injin distillation da juzu'i zazzabi
3.3 Tsarin amsawar cyclization: kula da zafin jiki da lokaci
3.4 1-Methyl-3-Pyrrolidinol injin distillation tsari: sarrafa injin injin distillation da juzu'i zazzabi
4. Wuraren kula da inganci:
Ma'anar kula da inganci 1: 1,2,4-Butanetriol albarkatun albarkatun kasa
Ma'anar kula da inganci 2: Matsayin ingancin kulawa na tsakiya don ɗaukar hawan keke
Matsayin kula da inganci 3: 1,4-Dichloro-2-Butanol matsakaicin ingancin inganci
Ma'anar kula da inganci 4: 1-Methyl-3-Pyrrolidinol ya gama daidaitaccen ingancin samfurin