5-Fluorocytosine (5-FC) CAS 2022-85-7 Tsarki ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Hanyar Bincike
Bayyanar-Fara ko Kusan Farin Foda
Asarar bushewa-Bushe shi a 105 don 4 hours: ya rasa fiye da 1.50% na nauyi.
Ragowa akan ƙonewa-ba fiye da 0.1% ba.
Karfe masu nauyi - bai wuce 0.002% ba.
Fluoride-Haɗa 70 ml na sabon bayani mai cikakken bayani na potassium chloride tare da 30 ml na barasa isopropyl, cika lantarki tare da madaidaicin haske, kuma ba da izinin lantarki ya kasance a cikin cakuda don ƙasa da sa'o'i 2 kafin amfani, ko zai fi dacewa da dare.
Lokacin ɗaukar ma'auni, canja wurin maganin zuwa ma'aunin 150-ml, kuma nutsar da na'urorin lantarki.Saka sandar motsawa mai rufaffiyar polytef a cikin beaker, sanya beaker a kan injin maganadisu mai rufin sama, kuma ba da damar motsawa har sai an sami daidaito (kimanin mintuna 1 zuwa 2).Kurkura da bushe na'urorin lantarki tsakanin ma'aunai, kula da kar a tona kristal a cikin takamaiman lantarki na ion.
Auna yuwuwar kowane Madaidaicin shiri, kuma ƙirƙira ƙaddamarwar fluoride, a cikin MG a kowace 100 ml, tare da yuwuwar, a cikin mV, akan takardar semilogarithmic.Auna yuwuwar shirye-shiryen gwajin, kuma ƙayyade daga daidaitaccen lanƙwasa ƙwayar fluoride, a cikin MG kowace 100 ml.Yi lissafin adadin fluoride a cikin ɓangaren Flucytosine da aka ɗauka ta dabara:
C/ 10
A cikin abin da C shine ƙwayar fluoride, a cikin MG a kowace 100 ml, daga daidaitaccen ma'auni: ba a sami fiye da 0.05% na fluoride ba.
Fluorouracil-Narke 250 MG a cikin 10 ml na cakuda glacial acetic acid da ruwa (4: 1).Aiwatar da 20 µL na wannan maganin zuwa farantin chromatographic na bakin ciki wanda aka lulluɓe da 0.5-mm Layer na cakuda gel silica chromatographic.A cikin farantin guda ɗaya ana amfani da 20 µL, a cikin haɓakar 10-µL, na 0.025 MG kowace ml na USP Fluorouracil RS a cikin cakuda glacial acetic acid da ruwa (4: 1).Ƙirƙirar chromatogram a cikin cakuda chloroform da glacial acetic acid (13: 7) har sai gaban sauran ƙarfi ya motsa bai wuce 14 cm daga asalin ba.Cire farantin daga ɗakin da ke tasowa, kuma ƙyale sauran ƙarfi ya ƙafe.Nemo tabo akan farantin ta hanyar lura a ƙarƙashin ɗan gajeren zangon UV radiation: duk wani tabo daga maganin da ke ƙarƙashin gwaji bai fi girma da ƙarfi fiye da tabo a daidaitaccen RF ɗin da aka samar da daidaitaccen bayani ba, wanda yayi daidai da bai wuce 0.1% na fluorouracil.
Assay-Wuri game da 400 MG na Flucytosine, daidai auna, a cikin 250-mL beaker, ƙara 150 ml na cakuda 2 juzu'i na glacial acetic acid da 1 girma na acetic anhydride, kuma narke, dumi a hankali idan ya cancanta.Titrate mai ƙarfi tare da 0.1 N perchloric acid VS, ta amfani da tsarin lantarki na calomel-glass.Yi ƙudiri mara kyau, kuma a yi duk wani gyara da ya dace.Kowane ml na 0.1 N perchloric acid yayi daidai da 12.91 MG na C4H4FN3O.Flucytosine ya ƙunshi bai wuce kashi 98.5 ba kuma bai wuce kashi 101.0 na C4H4FN3O ba, an ƙididdige shi akan busasshiyar tushe.