5-Methylisoxazole-4-Carboxylic Acid CAS 42831-50-5 Leflunomide Tsarkake Tsarkakewa>99.0% (HPLC)

5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) shine tsaka-tsaki don haɗin Leflunomide (CAS: 75706-12-6).Leflunomide wani nau'i ne na magungunan rigakafi na isoxazole tare da aikin rigakafin yaduwa, ilimin harhada magunguna na zamani ya rarraba wannan samfurin a matsayin magungunan antipyretic, analgesic da anti-mai kumburi.Ana iya canza wannan samfurin da sauri zuwa metabolites masu aiki kuma suna taka rawa ta hanta da cytoplasm na hanji da microsomes, nasa;Babban tsarin shine a lokacin haɗin DNA, yana hana aiki mai mahimmanci-DHODH (DHODH), don haka nucleotides a cikin B lymphocyte ya ƙare, yana ƙare biosynthesis na DNA da RNA, sel ba za su iya shiga cikin lokaci ba, kuma a ƙarshe ba za su iya shiga ba. yaduwa, wanda ya haifar da sakamako na anti-rheumatic, ya dace da maganin tsofaffi tare da cututtukan cututtuka na rheumatoid mai aiki, ankylosing spondylitis, zai iya rage lalata kashi, rage alamun bayyanar cututtuka da alamun.Bugu da ƙari, leflunomide kuma zai iya hana aikin tyrosine kinase, ta haka ne ya hana yaduwar kwayoyin T, B cell da kuma kwayoyin da ba na rigakafi ba, amma kuma, ta hanyar hana biosynthesis na cyclooxygenase-2 (COX2), ya hana prostaglandin kira da kuma yin amfani da anti-mai kumburi. tasirin kumburi da hana ƙwayoyin mast da sakin histamine basophils.Lokacin da aka yi amfani da wannan samfurin a cikin marasa lafiya da aka dasa gabobin jiki, daidaitawar kashi yana da wahala, ana amfani da shi musamman don magance cututtukan cututtuka na rheumatoid da sauran cututtuka na autoimmune.