Acesulfame K CAS 55589-62-3 Acesulfame Potassium Tsabta > 99.0% (HPLC)

BAYANI
Acesulfame Potassium ya ƙunshi NLT 99.0% da NMT 101.0% na C4H4NO4SK, ƙididdiga akan busasshen tushe.
GANO
• A. RASHIN NUTSUWA <197K>
• B. GWAJIN GANE-JAMA'A, Potassium <191>
Maganin samfurin: 100 mg/ml
Sharuɗɗan karɓa: Ya cika buƙatun
ASSAY
• TSARI
Misali: 150 MG
Tsarin Titrimetric (Duba Titrimetry <541>)
Yanayin: Kai tsaye titration
Titrant: 0.1 N perchloric acid VS
Blank: 50 ml na glacial acetic acid
Gano ƙarshen ƙarshen: Potentiometric
Bincike: Narke Samfurin a cikin 50 ml na glacial acetic acid.
Titrate tare da 0.1 N perchloric acid VS.Yi yanke shawara mara kyau.
Yi lissafin adadin acesulfame potassium (C4H4NO4SK) a cikin Samfura:
Sakamako = [(V - B) × N × F × 100]/W
V = ƙarar titrant da Samfurin (mL) ke cinyewa
B = ƙarar titrant da Blank (mL) ke cinyewa
N = Titrant ainihin al'ada (mEq/ml)
F = daidaitattun ma'auni, 201.2 mg/mEq
W = Nauyin Samfurin (mg)
Sharuɗɗan karɓa: 99.0% -101.0% akan busasshen tushe
RASHIN ZUCIYA
• IYAKA NA FLUORIDE
[NOTE-Yi amfani da kayan filastik a duk wannan gwajin.]
Magani A: Narke 210 g na citric acid monohydrate a cikin 400 ml na ruwa.Daidaita tare da maida hankali ammonia zuwa pH na 7.0, kuma tsarma da ruwa zuwa 1000 ml.
Magani B: 132 mg/mL na dibasic ammonium phosphate
Magani C: Don dakatar da 292 g na edetic acid a cikin 500 ml na ruwa, ƙara 200 ml na ammonium hydroxide, daidaita tare da ammonium hydroxide zuwa pH tsakanin 6 da 7, kuma tsarma da ruwa don yin 1000 ml.
Maganin buffer: Haɗa daidai adadin Magani A, Magani B da Magani C, kuma daidaita tare da ammonium hydroxide zuwa pH na 7.5.
Matsakaicin bayani na jari: Auna 0.442 g na sodium fluoride, a baya an bushe a 300 ° na awanni 12, a cikin flask volumetric 1-L, kuma a tsoma shi da ruwa zuwa girma.Ajiye maganin a cikin rufaffiyar kwandon filastik.Nan da nan kafin amfani, pipet 5 ml na wannan maganin a cikin 100-mL volumetric flask, da kuma tsarma da ruwa zuwa girma.Kowane ml na wannan maganin ya ƙunshi 10µg na fluoride ion.
Daidaitaccen bayani A: Mix 0.5 ml na daidaitaccen bayani na hannun jari da 15.0 ml na maganin Buffer, kuma a tsoma shi da ruwa zuwa 50ml.
Daidaitaccen bayani na B: Mix 1.0 ml na daidaitaccen bayani na hannun jari da 15.0 ml na maganin Buffer, kuma a tsoma shi da ruwa zuwa 50ml.
Magani mai mahimmanci C: Mix 1.5 ml na daidaitaccen bayani na hannun jari da 15.0 ml na maganin Buffer, kuma a tsoma shi da ruwa zuwa 50ml.
Daidaitaccen bayani D: Mix 3.0 ml na daidaitaccen bayani na hannun jari da 15.0 ml na maganin Buffer, kuma a tsoma shi da ruwa zuwa 50ml.
Maganin samfurin: Zuwa 50-mL flask volumetric ƙara 3 g na Acesulfame Potassium.Narke cikin ruwa, ƙara 15.0 ml na maganin Buffer, kuma tsarma da ruwa zuwa ƙarar.
Bincike
Misalai: Maganin daidaitaccen A, Daidaitaccen Maganin B, Daidaitaccen Maganin C, Daidaitaccen Maganin D, da Maganin Samfuri
A lokaci guda auna yuwuwar (duba Titrimetry <541>) a cikin mV, na Ma'auni na Ma'auni da Maganin Samfurin, tare da mitar pH mai dacewa sanye take da na'urar ta musamman ta fluoride da na'urar magana ta azurfa-azurfa chloride.Lokacin ɗaukar ma'aunai, canja wurin maganin zuwa beaker 25-mL, kuma nutsar da na'urorin lantarki.Saka sandar motsawa mai rufaffiyar polytef a cikin beaker, sanya beaker a kan injin maganadisu mai rufin sama kuma ba da damar motsawa har sai an sami daidaito (minti 1-2).Kurkura, kuma bushe na'urorin lantarki tsakanin ma'aunai, kula da kar a tono crystal a cikin takamaiman ion electrode.Auna yuwuwar kowane Madaidaicin bayani, kuma ƙirƙira ƙaddamarwar fluoride, a cikin µg/mL, tare da yuwuwar, a cikin mV, akan takarda na semilogarithmic.Auna yuwuwar Maganin Samfurin, kuma ƙayyade ƙimar fluoride daga daidaitaccen lanƙwasa, a cikin µg/mL.
Yi lissafin abun ciki, a cikin ppm, na fluoride a cikin ɓangaren Acesulfame Potassium da aka ɗauka:
Sakamako = (V × C/W)
V = ƙarar samfurin maganin (mL)
C = maida hankali na fluoride a cikin Samfurin bayani, daga daidaitaccen lanƙwasa (mg/mL)
W = nauyin Acesulfame Potassium da aka ɗauka don shirya Samfurin maganin (g)
Sharuɗɗan karɓa: NMT 3 ppm
• KARFE MAI KYAU, Hanyar I <231>: NMT 10 ppm
• TSARKI CHOMATOGRAPHIC
Magani A: 3.3 mg/mL na tetrabutylammonium hydrogen sulfate
Lokacin Wayar hannu: Acetonitrile da Magani A (2:3)
Maganin dacewa da tsarin: 2 µg/ml kowane na USP Acesulfame Potassium RS da ethylparaben
Daidaitaccen bayani: 0.2 µg/ml na USP Acesulfame Potassium RS
Samfurin bayani: 10 mg/ml
Tsarin chromatographic
(Duba Chromatography <621>, Dacewar Tsarin.)
Yanayin: LC
Mai ganowa: UV 227 nm
Tushen: 4.6-mm × 25-cm;5-µm shiryarwa L1
Yawan gudu: 1 ml/min
Girman allura: 20µL
Dacewar tsarin
Misali: Maganin dacewa da tsarin
Abubuwan da suka dace
Resolution: NLT 2 tsakanin acesulfame potassium da ethylparaben
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi rikodin chromatograms don lokacin gudu NLT sau 3 na lokacin riƙewar acesulfame potassium peak, kuma auna martanin yanki na kololuwa.
Sharuɗɗan karɓa: Amsar kowane kololuwa a lokacin riƙewa banda na acesulfame potassium daga Maganin Samfurin bai wuce martanin acesulfame potassium peak daga daidaitaccen bayani (0.002%).
MAKAMMAN JARRABAWA
• ACIJI KO ALKALINCI
Samfurin bayani: 4.0 g a cikin 20 ml na ruwa mara kyau na carbon dioxide
Analysis: Ƙara 0.1 ml na bromothymol blue TS.Idan maganin rawaya ne, titrate tare da 0.01 N sodium hydroxide don samar da launin shuɗi.Idan maganin shuɗi ne, titrate tare da 0.01 N hydrochloride acid don samar da launin rawaya.
Sharuɗɗan karɓa: NMT 0.2 ml na 0.01 N sodium hydroxide ko NMT 0.2 ml na 0.01 N hydrochloric acid ana buƙata.
• RASHIN BUSHEWA <731>: Busa samfurin a 105 ° na 3 h: yana rasa NMT 1.0% na nauyinsa.
KARIN BUKATA
• KYAUTA DA ARJIYA: Ajiye a cikin akwati da ke da kyau, da kuma kariya daga haske.Ajiye a zafin jiki.
MATSAYIN NAZARI NA USP <11>
USP Acesulfame Potassium RS