Afatinib CAS 439081-18-2 Tsarkake>99.5% (HPLC) Factory

Afatinib, wanda kuma aka sani da BIW-2992, (CAS: 439081-18-2) shine ƙarni na biyu mai ƙarfi kuma mai hanawa mai hanawa mai haɓaka haɓakar haɓakar epidermal (EGFR) da mai karɓar haɓakar haɓakar ɗan adam 2 (HER2) tyrosine kinase, Boehringer Ingelheim, Jamus ne ya haɓaka.Yana da ikon hana aikin tyrosine kinase ba tare da jurewa ba ta hanyar jurewa amsawar Michael tare da ƙungiyar thiol na cysteine ​​a matsayi na 797 na EGFR.A ranar 12 ga Yuli, 2013, ya zama sabon magani ga cutar kansar huhu da ƙananan ƙwayoyin cuta da FDA ta Amurka ta amince da su a ƙarƙashin sunan kasuwanci na Gilotrif.Wannan magani shine kwamfutar hannu.Ana amfani da shi don kula da marasa lafiya da aka gano tare da ciwon huhu marasa ƙananan ƙwayar cuta (NSCLC) tare da asarar 19th exon ko L858R maye gurbi a cikin 21th exon na ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (NSCLC) da FDA.Har ila yau, miyagun ƙwayoyi yana da tasiri a cikin maganin HER2-tabbatacce marasa lafiya tare da ci gaba da ciwon nono.Afatinib na cikin rukunin magungunan da aka sani da masu hana tyrosine kinase.An tsara magungunan Tyrosine kinase don toshe aikin wani takamaiman enzyme da ake kira tyrosine kinase.Wannan enzyme yana taka rawa sosai a cikin aikin sel, kuma yana aiki don haɓaka haɓakar ƙari da ci gaba.Afatinib yana aiki don hana aikin nau'ikan nau'ikan tyrosine kinases guda biyu: mai karɓar haɓakar haɓakar haɓakar epidermal (EGFR) da Her2, waɗanda nau'ikan ciwon daji da yawa ke “bayyana su”.Ta hanyar toshe aikin waɗannan tyrosine kinases, Afatinib na iya hana ƙwayoyin cutar kansa rarrabuwa da girma.