Afatinib Dimaleate Intermediate CAS 314771-76-1 Tsarkake>99.0% (HPLC) Hoton Factory

Afatinib Dimaleate Intermediate CAS 314771-76-1 Tsarkake>99.0% (HPLC) Factory

Takaitaccen Bayani:

Sunan Chemical: (S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine

Saukewa: 314771-76

Tsafta:> 99.0% (HPLC)

Bayyanar: Rawaya Mai Haske zuwa Fada Rawaya

Matsakaicin Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Cikakken Bayani

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Tags samfurin

Bayani:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -daya CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineSaukewa: CAS314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy) quinazolin-4-AmineSaukewa: CAS314771-88-5

Abubuwan Sinadarai:

Sunan Sinadari	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine
Makamantu	N4- (3-Chloro-4-Fluorophenyl) -7-[[(3S) -Tetrahydro-3-Furanyl] oxy] -4,6-Quinazolinediamine;Afatinib Najasa B;Afatinib-des (4-Dimethylamino-2-en-1-oxo)butyl;Des (4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Lambar CAS	314771-76-1
Lambar CAT	Saukewa: RF-PI2028
Matsayin Hannun jari	A cikin Hannun jari, Ƙarfin Ƙirƙirar 100MT/Shekara
Tsarin kwayoyin halitta	Saukewa: C18H16ClFN4O2
Nauyin Kwayoyin Halitta	374.8
Wurin Tafasa	559.0 ± 50.0 ℃
Yawan yawa	1.473 ± 0.060 g/cm3
Alamar	Ruifu Chemical

Ƙayyadaddun bayanai:

Abu	Ƙayyadaddun bayanai
Bayyanar	Rawaya Mai Haske zuwa Foda Rawaya
Ganewa	Lokacin Riƙon Babban Kololuwa a cikin HPLC Ya Kamata Yayi Daidai da Ƙimar
Tsarkake / Hanyar Bincike	> 99.0% (HPLC)
Asara akan bushewa	<0.50%
Ragowa akan Ignition	<0.20%
Tsaftace Guda Daya	<0.50%
Jimlar ƙazanta	<1.00%
Karfe masu nauyi (kamar Pb)	≤20ppm
Matsayin Gwaji	Matsayin Kasuwanci
Amfani	Matsakaicin Afatinib Dimaleate (CAS: 850140-73-7)

Kunshin & Ajiya:

Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata

Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi

Amfani:

FAQ:

Aikace-aikace:

(S) -N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine (CAS: 314771-76-1) shine matsakaici na Afatinib Dimaleate. (CAS: 850140-73-7).Afatinib shine ƙarni na biyu mai ƙarfi kuma mai hanawa dual inhibitor na mai karɓar haɓakar haɓakar haɓakar epidermal (EGFR) da mai karɓar haɓakar haɓakar haɓakar ɗan adam 2 (HER2) tyrosine kinase, wanda Boehringer Ingelheim, Jamus ya haɓaka.Yana da ikon hana aikin tyrosine kinase ba tare da jurewa ba ta hanyar jurewa amsawar Michael tare da ƙungiyar thiol na cysteine a matsayi na 797 na EGFR.Aiki: 1. Kamar Lapatinib da Neratinib, Afatinib shine furotin kinase inhibitor wanda kuma ba zai iya jurewa ba yana hana mai karɓar haɓakar haɓakar haɓakar ɗan adam 2 (Her2) da kuma mai karɓar haɓakar haɓakar haɓakar epidermal (EGFR) kinases.2. Afatinib ba wai kawai yana aiki ne a kan maye gurbi na EGFR da TKIs na ƙarni na farko suka yi niyya kamar erlotinib ko gefitinib ba, har ma da maye gurbi irin su T790M waɗanda ba su kula da waɗannan ƙa'idodi na yau da kullun.Saboda ƙarin ayyukansa akan Her2, ana bincikar cutar kansar nono da sauran cututtukan daji na EGFR da Her2.3. Afatinib magani ne don maganin layin farko na marasa lafiya tare da nau'ikan nau'ikan metastatic (EGFR mutation positive) wadanda ba ƙananan ƙwayoyin huhu ba (NSCLC).Yana aiki azaman mai hana mai karɓar mai karɓar tyrosine kinases epidermal girma factor receptor (EGFR) da erbB-2 (HER2).