Anastrozole CAS 120511-73-1 API High Quality Factory

Anastrozole (CAS 120511-73-1), ba steroidal ba, na uku na achiral triazole wanda aka sayar da shi azaman ARIMIDEX® ta AstraZeneca Pharmaceuticals LP1.Yana daya daga cikin na uku-ƙarni aromatase inhibitor wanda yake shi ne mai matukar gasa da kuma zaɓaɓɓen inhibitor na aromatase, don haka yana toshe canjin testosterone cikin estradiol da androstenedione cikin estrone.Hana enzyme na aromatase yana faruwa musamman ta hanyar haɗakar aromatase zuwa ƙungiyar cytochrome P450, rage yawan isrogen biosynthesis a cikin kyallen jikin jiki da a cikin nono.

Anastrozole magani ne da ake jurewa gabaɗaya don ciwon nono na farko.Kamar sauran masu hanawa na aromatase, mafi mahimmancin tasirinsa shine haɓakar haɓakar kasusuwa, wanda don anastrozole ya iyakance ga lokacin jiyya.Yana da halayyar ɗanɗano mai laushi idan aka kwatanta da chemotherapy;duk da haka, an lura cewa yawancin marasa lafiya da aka yi wa maganin anastrozole sun koka da alamun haɗin gwiwa fiye da yadda ake tsammani, musamman maɗaurin dijital kamar na rheumatoid arthritis.Wasu gwaje-gwaje na asibiti na anastrozole ga matan da suka shude da ciwon nono a Turai da Amurka sun ba da rahoton cututtuka na musculoskeletal a matsayin abubuwan da ba su da kyau.Anastrozole (Arimidex®) shine mai hana aromatase wanda aka amince dashi a cikin EU, Amurka da sauran ƙasashe a duniya don amfani dashi azaman magani a cikin matan postmenopausal tare da matakin farko, ciwon daji na nono mai karɓa na hormone.An kuma amince da ita a cikin EU da sauran ƙasashe na duniya don ci gaba da maganin jinya a cikin matan da suka riga sun sami shekaru 2-3 na maganin tamoxifen adjuvant don ciwon nono.