Baloxavir Marboxil CAS 1985606-14-1 API Factory High Quality Featured Hoton

Baloxavir Marboxil CAS 1985606-14-1 API High Quality Factory

Takaitaccen Bayani:

Sunan Chemical: Baloxavir Marboxil

Saukewa: 1985606-14-1

Bayyanar: Fari zuwa Kashe-fari foda

Matsayi: 98.0% ~ 102.0%

A cikin maganin cutar mura A da mura B

Tuntuɓi: Dr. Alvin Huang

Wayar hannu/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Cikakken Bayani

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Bayani:

Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na Baloxavir Marboxil (CAS: 1985606-14-1) tare da inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Abubuwan Sinadarai:

Sunan Sinadari	Baloxavir Marboxil
Makamantu	BXM;S-033188
Lambar CAS	1985606-14-1
Matsayin Hannun jari	A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram
Tsarin kwayoyin halitta	Saukewa: C27H23F2N3O7S
Nauyin Kwayoyin Halitta	571.55
Yawan yawa	1.57± 0.10 g/cm3
Solubility	Mai narkewa a cikin DMSO
Adana Tsawon Lokaci	Adana Dogon lokaci a -20 ℃
COA & MSDS	Akwai
Asalin	Shanghai, China
Alamar	Ruifu Chemical

Ƙayyadaddun bayanai:

Abu	Ƙayyadaddun bayanai
Bayyanar	Fari zuwa Kashe-Farin Foda
Ganewa	Spectrum IR yayi daidai da ma'aunin tunani Lokacin riƙewa yayi daidai da ma'aunin tunani
Abubuwan Ruwa (na KF)	≤1.0%
Asara akan bushewa	≤1.0%
Ragowa akan Ignition	≤0.50%
Karfe masu nauyi	≤20ppm
Abubuwa masu alaƙa
Matsakaicin Tsabtace Mutum	≤0.50%
Jimlar ƙazanta	≤1.0%
Girman Barbashi	D90 Pass 150um
Chiral Tsafta	≥99.0%
Tsafta	≥99.0%
Assay	98.0% ~ 102.0%
Ragowar Magani	Bi Bukatun ICH
Jirgin ruwa	Shipping Tare da Kunshin Ice
Matsayin Gwaji	Matsayin Kasuwanci
Amfani	API, a cikin maganin cutar mura A da mura B

Kunshin & Ajiya:

Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.

Amfani:

FAQ:

1985606-14-1 - Aikace-aikace:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) maganin rigakafi ne wanda Shionogi Co., wani kamfanin harhada magunguna na Japan da Roche suka kirkira don maganin mura A da cututtukan mura B.An fara amincewa da miyagun ƙwayoyi don amfani a Japan a cikin Fabrairu 2018 kuma FDA ta amince da ita a ranar 24 ga Oktoba, 2018 don maganin mura mai tsanani a cikin marasa lafiya masu shekaru 12 da haihuwa waɗanda ke da alamun bayyanar cututtuka fiye da 48 Label.Baloxavir marboxil, mai hana cap-endonuclease, yana da tsarin aiki na musamman idan aka kwatanta da rukunin magungunan neuraminidase na yanzu da ake amfani da shi don magance cututtukan mura.Baloxavir Marboxil sabon maganin mura ne tare da sabon tsarin aiki.Baloxavir Marboxil shine prodrug na Baloxavir Acid (S-033447) wanda ke da ƙarfi da zaɓi yana hana endonuclease mai dogaro da hula a cikin rukunin polymerase PA na ƙwayoyin mura A da B, yana haifar da hana kwafin RNA da kwafi.An kuma bincika Baloxavir don yuwuwar sa na yin maganin COVID-19 amma ba a sami ingantaccen fa'ida ba.

1985606-14-1 - Tsarin Aiki:

Baloxavir Marboxil wakili ne na maganin mura, musamman, mai hana enzyme wanda ke yin niyya ga ayyukan endonuclease mai dogaro da cutar mura, ɗayan ayyukan ƙwayar cuta ta polymerase.Musamman ma, tana hana wani tsari da aka sani da satar hula, wanda kwayar cutar ke samun gajerun hanyoyi, da aka rufe ta daga kwafin RNA mai masaukin baki, wanda sai ta yi amfani da ita don haɗakar da polymerase-catalyzed na mRNAs ɗin da ake buƙata.Subunit na polymerase yana ɗaure ga pre-mRNAs mai watsa shiri a iyakoki na 5', sa'an nan aikin endonuclease na polymerase yana haifar da ɓarkewar sa "bayan 10-13 nucleotides".Don haka, tsarin sa ya bambanta da masu hana neuraminidase kamar Oseltamivir da Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil ne mai zaɓaɓɓen mai hana kamuwa da cutar mura cap-dogara endonuclease wanda ke hana aikin polymerase sabili da haka kwayar cutar mura mRNA kwafi 5, 3. Ya nuna aikin warkewa daga mura A da B ƙwayoyin cuta, ciki har da nau'ikan da ke da tsayayya ga magungunan antiviral na yanzu 1. Wannan magani. yana hana enzyme da ake buƙata don kwafi, don haka da sauri magance kamuwa da cutar mura 5, Lakabi da rage alamun da ke tattare da kamuwa da cuta.An nuna kashi ɗaya na wannan wakili ya fi placebo wajen kawar da alamun mura kuma ya fi duka oseltamivir da placebo miyagun ƙwayoyi a cikin sakamakon virologic (alama ta hanyar rage nauyin hoto).

1985606-14-1 - Alamu:

Baroxavir ya dace da marasa lafiya ≥ 12 shekaru da ke fama da murar da ba ta da rikitarwa kuma wanda alamunsa ba su wuce sa'o'i 48 ba.Ya kamata a mai da hankali ga iyakancewar magunguna: ƙwayar cutar mura tana canzawa akan lokaci, kuma akwai dalilai kamar nau'in ƙwayoyin cuta da nau'in nau'in cuta.Da zarar juriya na miyagun ƙwayoyi na ƙwayoyin cuta da ƙwayoyin cuta na ƙwayoyin cuta sun canza, ƙwarewar asibiti na magungunan ƙwayoyin cuta na iya raunana.Lokacin da za a yanke shawarar ko za a ɗauki basalovir dipivoxil, bayanan da ke akwai game da ji na ƙwayar ƙwayar cuta ta gida ga miyagun ƙwayoyi ya kamata a yi la'akari da su.

1985606-14-1 - Amfani:

Baloxavir Marboxil magani ne na mura, maganin rigakafi, wanda ake ɗauka azaman kwamfutar hannu guda ɗaya, ta baki, ta mutanen da ke da shekaru 12 ko sama da haka, waɗanda suka gabatar da alamun wannan kamuwa da cuta don bai wuce sa'o'i 48 ba. baloxavir marboxil da ake gudanarwa bayan sa'o'i 48 ba a gwada shi ba.

1985606-14-1 - Contraindications:

Baloxavir Marboxil bai kamata a hada shi tare da kayan kiwo, abubuwan sha masu ƙarfi na calcium, ko laxatives, antacids, ko abubuwan da suka ƙunshi calcium, iron, magnesium, selenium, aluminum ko zinc.

1985606-14-1 - Tasirin Gaba:

Abubuwan da aka saba amfani da su bayan gudanar da kashi ɗaya na baloxavir marboxil sun haɗa da gudawa, mashako, mura, ciwon kai, da tashin zuciya.An ba da rahoton abubuwan da ba su da kyau a cikin 21% na mutanen da suka karɓi baloxavir, 25% na waɗanda ke karɓar placebo, da 25% na Oseltamivir.

1985606-14-1 - Shiri:

Patent Jafananci JP6212678 ya ruwaito hanyar haɗin Baloxavir Marboxil.3, 4-difluorobenzoic acid an yi amfani dashi azaman albarkatun ƙasa don amsawa tare da DMF a ƙarƙashin aikin LDA don samun 2-formyl-3, 4-difluorobenzoic acid.Sa'an nan kuma ya samar da thioacetal da thiophenol, sannan a rage shi a rabu da borane don samun 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -daya, kuma a karshe mabuɗin thiazepine guda ɗaya. 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-giya yana samuwa a ƙarƙashin raguwar sodium borohydride.Yin amfani da 3- (benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid don amsawa tare da tsarin tert-butyl bayan esterification don samun 3- (benzyloxy) -1- ((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, sa'an nan kuma tare da 2- (2-, 2-dimethoxyethoxy) ethylamine yana jurewa urethane musayar amsawa, sa'an nan kuma cyclizes a karkashin aikin methanesulfonic acid don samun 7- (benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, to shi ne condensed tare da (R) -tetrahydrofuran -2-formic acid, sa'an nan crystallized da kuma warware, sa'an nan kuma chiral auxiliary kungiyar an cire don samun key chiral mahaifa zobe kwayoyin (R) -7- (benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f] [1,4] Triazine-6, 8-dione.Sa'an nan kuma ana amfani da kwayoyin zobe na maɓalli don musayar tare da n-hexanol a ƙarƙashin aikin Grignard reagent, sa'an nan kuma tare da maɓallin thiazepine 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-docking barasa. , kuma a ƙarshe debutylation da condensation tare da methyl chloroformate don samun samfurin ƙarshe na Baloxavir Marboxil.