Bortezomib CAS 179324-69-7 Tsabtace ≥99.0% (HPLC) API Babban Tsabta
Samar da Matsakaici masu alaƙa da Bortezomib tare da Babban Tsafta
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Bortezomib CAS 179324-69-7
| Sunan Sinadari | Bortezomib |
| Makamantu | Velcade, MG-341, PS-341 |
| Lambar CAS | 179324-69-7 |
| Lambar CAT | RF-API65 |
| Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
| Tsarin kwayoyin halitta | Saukewa: C19H25BN4O4 |
| Nauyin Kwayoyin Halitta | 384.24 |
| Matsayin narkewa | 122.0 ~ 124.0 ℃ |
| Yawan yawa | 1.214 |
| Fihirisar Refractive | 1.564 |
| Solubility | Mai narkewa a cikin Chloroform, DMSO, Ethanol da Methanol |
| Kwanciyar hankali | Hygroscopic da Danshi Sensitive |
| Yanayin jigilar kaya | An aika Karkashin Zazzabin yanayi |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari ko Kashe-Farin Foda |
| Tsarkake / Hanyar Bincike | ≥99.0% (HPLC) |
| Asara akan bushewa | ≤0.50% |
| Ragowa akan Ignition | ≤0.20% |
| Juyawar gani | -41.0° ~ -46.0° |
| Karfe mai nauyi | ≤20ppm |
| Acidity | 4.0 ~ 7.0 |
| Isomer | ≤0.50% |
| Tsaftace Guda Daya | ≤0.50% |
| Jimlar ƙazanta | ≤1.0% |
| Ragowar Magani | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl acetate | ≤0.50% |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | API |
Kunshin: Bottle, Aluminum tsare jakar, Kwali Drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Shanghai Ruifu Chemical Co., Ltd. shine babban masana'anta kuma mai ba da kayayyaki na Bortezomib (CAS: 179324-69-7) tare da babban inganci, API.
Bortezomib, wanda ake sayar da shi a ƙarƙashin sunan alamar Velcade da sauransu, magani ne na rigakafin ciwon daji da ake amfani dashi don magance myeloma da yawa da lymphoma na mantle cell.An amince da Bortezomib don amfani da magani a Amurka a cikin 2003 da kuma a cikin Tarayyar Turai a 2004. Yana cikin Jerin Mahimman Magunguna na Hukumar Lafiya ta Duniya.Bortezomib shine farkon mai hana proteasome da aka yarda da FDA ta Amurka don myeloma mai yawa, ciwon daji na jini.Mai hanawa mai jujjuyawa na 26S proteasome-barbashi mai siffa mai siffar ganga da aka samo a cikin tsakiya da cytosol na duk ƙwayoyin eukaryotic.Bortezomib zaɓi ne kuma mai ƙarfi na 26S proteasome inhibitor, wanda shine tushen boronic acid dipeptide.Nazarin ciwon daji na ɗan adam yana nuna Bortezomib don hana PKR-kamar endoplasmic reticulum (ER) kinase da haɓaka damuwa na ER, wanda ke haifar da apoptosis.
