Capecitabine CAS 154361-50-9 Tsabtace 98.0% ~ 102.0% API Babban Ingancin
Samar da Kasuwancin Capecitabine Matsakaici masu dangantaka:
5-Fluorocytosine CAS: 2022-85-7
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS: 161599-46-8
1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9
| Sunan Sinadari | Capecitabine |
| Lambar CAS | 154361-50-9 |
| Lambar CAT | RF-API08 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C15H22FN3O6 |
| Nauyin Kwayoyin Halitta | 359.35 |
| Matsayin narkewa | 110.0 ~ 121.0 ℃ |
| Yanayin jigilar kaya | Karkashin Zazzabi |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Farin Foda |
| Ganewa | Samfurin Spectrum na IR yakamata ya daidaita tare da bakan ma'aunin ma'auni |
| Ganewa | HPLC: Lokacin riƙewa na babban kololuwar samfurin mafita yakamata yayi daidai da na ma'aunin tunani. |
| Tsafta | 98.0% ~ 102.0% (a kan anhydrous da sauran ƙarfi-free tushen) |
| Juyawar gani | +96.0°~+100° |
| Danshi (KF) | ≤0.30% |
| Ragowa akan kunnawa | ≤0.10% |
| Karfe masu nauyi | ≤20ppm |
| Rashin Tsabta Mai Ma'ana A | ≤0.30% |
| Abubuwan da ke da alaƙa da rashin tsarki B | ≤0.30% |
| Rashin Tsabtace Mai Ma'ana C | ≤0.10% (2',3'-Di O-Acety-5'-deoxy-5-Fluoroytidine) |
| Rashin Tsabtace Guda Daya | ≤0.10% |
| Jimlar ƙazantattun da ba a fayyace su ba | ≤0.50% |
| Jimlar ƙazanta | ≤1.5% |
| Residual Solvents (GC) | |
| Methanol | ≤3000ppm |
| Ethanol | ≤5000ppm |
| Dichloromethane | ≤600ppm |
| Ethyl acetate | ≤5000ppm |
| Toluene | ≤800ppm |
| Pyridine | ≤200ppm |
| Hexane | ≤290ppm |
| Jimlar Ƙididdigar Ƙwayoyin Ƙirar Ƙira | ≤200cfc/g |
| Yisti da Molds ƙidaya | ≤50cfc/g |
| Matsayin Gwaji | Amurka Pharmacopoeia (USP) |
| Amfani | Metastatic Breast Cancer |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Capecitabine (CAS: 154361-50-9) wani sabon nau'i ne na maganin pyrimidine mai fluorinated.Kamfanin na Roche Pharmaceuticals ne ya kirkiro Capecitabine, kuma sunansa na kasuwanci Xeloda.Capecitabine na iya canzawa a cikin vivo zuwa 5-FU, wani anti-metabolizim fluorine pyrimidine deoxynucleoside carbamate miyagun ƙwayoyi wanda ke kaiwa ga kwayoyin cutar kansa don hana rarrabawar cell kuma ya rushe RNA da haɗin furotin.Abubuwan da ke tattare da shi suna da alaƙa sosai da matakin maganganun enzyme na TP a cikin nama na neoplastic da zuwa DPD enzyme a cikin maganganun vivo.Ya dace a matsayin ƙarin jiyya don ci gaba na farko ko masu cutar kansar nono waɗanda ba su amsa maganin rigakafi na paclitaxel ko anthracycline ba.A matsayin maganin cutar kansa, ana amfani da shi galibi don magance ciwon nono na farko ko na metastatic, da kuma maganin cutar kansar huhu mara ƙanƙanta, kansar pancreatic, kansar mafitsara, kansar dubura, kansar hanji, ciwon ciki, da sauran ciwace-ciwace. .
