Carvedilol CAS 72956-09-03 Tsaftace>99.0% (HPLC) Fitaccen Hoton

Carvedilol CAS 72956-09-03 Tsafta > 99.0% (HPLC)

Takaitaccen Bayani:

Sunan Chemical: Carvedilol

Saukewa: 72956-03

Tsafta:> 99.0% (HPLC)

Bayyanar: Farin Crystalline Foda

Tuntuɓi: Dr. Alvin Huang

Wayar hannu/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Bayani:

Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na Carvedilol (CAS: 72956-09-03) tare da babban inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Carvedilol,Please contact: alvin@ruifuchem.com

Matsakaici masu alaƙa:

Matsakaici masu alaƙa na Carvedilol

N- (2- (2-Methoxyphenoxy) ethyl) benzylamine Hydrochloride	Saukewa: 3246-03-5
2- (2-Methoxyphenoxy) Ethylamine Hydrochloride Hydrate	Farashin 64464-07-9
2- (2-Methoxyphenoxy) ethylamine	Farashin 1836-62-0
4- (2,3-Epoxypropoxy) carbazole	Saukewa: CAS51997-51-4
4-Hydroxycarbazole	Saukewa: CAS52602-39-8
1,3-Cyclohexanedione	Farashin 504-02-9
Carvedilol	Farashin 72956-09-03
Carvedilol Phosphate Hemihydrate	Saukewa: CAS610309-89-2

Abubuwan Sinadarai:

Sunan Sinadari	Carvedilol
Makamantu	1- (9H-Carbazol-4-yloxy) -3-[2- (2-Methoxyphenoxy) ethyl] amino] -2-Propanol;Mawaƙi;Cadilan;Karka;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Matsayin Hannun jari	A Stock, GMP Commercial
Lambar CAS	72956-09-3
Tsarin kwayoyin halitta	Saukewa: C24H26N2O4
Nauyin Kwayoyin Halitta	406.48 g/mol
Matsayin narkewa	115.0 zuwa 119.0 ℃
Yawan yawa	1.250± 0.06 g/cm3
Solubility a cikin Ruwa	Mara narkewa a cikin Ruwa
Solubility	Mai narkewa a cikin methanol.Dan Soluble a cikin Ethanol, Ether
Adana Yanayin.	Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃)
COA & MSDS	Akwai
Alamar	Ruifu Chemical

Ƙayyadaddun bayanai:

Abubuwa	Ka'idojin dubawa	Sakamako
Bayyanar	Farin Crystalline Foda	Ya bi
Asara akan bushewa	≤0.50% (105 ℃ na 3 h)	0.25%
Ragowa akan Ignition	≤0.10%	0.07%
Abubuwa masu alaƙa
Jimlar ƙazanta	≤0.50%	Ya bi
Najasa A	≤0.20%	Ya bi
Rashin tsarki C	≤0.02%	Ya bi
Duk Wani Rashin Tsabtace Mutum	≤0.10%	Ya bi
Karfe masu nauyi (Pb)	≤10ppm	<10ppm
Tsarkake / Hanyar Bincike	> 99.0% (HPLC)	99.72%
Infrared Spectrum	Yayi daidai da Tsarin	Ya bi
Kammalawa	An gwada samfurin kuma ya dace da ƙayyadaddun bayanai

Kunshin/Ajiye/Jirgin ruwa:

Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin akwati da aka rufe sosai.Ajiye a cikin sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.

Amfani:

Isasshen Ƙarfin: isassun wurare da masu fasaha

Sabis na Ƙwararru: Sabis na siyan tasha ɗaya

Kunshin OEM: Kunshin al'ada da alamar akwai

Bayarwa da sauri: Idan yana cikin haja, garantin isar da kwanaki uku

Ƙarfin Ƙarfi: Kula da haja mai ma'ana

Taimakon Fasaha: Akwai maganin fasaha

Sabis na Haɗa na Musamman: Ya bambanta daga gram zuwa kilos

High Quality: An kafa cikakken tsarin tabbatar da inganci

FAQ:

Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.

Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.

Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.

inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.

Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.

Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.

MOQ?Babu MOQ.Karamin tsari abin karɓa ne.

Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.

Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.

Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.

Haɗin Kan Al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.

Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.

72956-09-3 - Bayanin Tsaro:

Lambobin haɗari N, Xn
Bayanin Hatsari 51/53-36/37/38-20/21/22
Bayanan Tsaro 61-36-26
RIDADR UN 3077 9/PG 3
WGK Jamus 3
Saukewa: UA8670000
HazardClass IRITANT
PackingGroup III
Bayanan Abubuwan Haɗari 72956-09-3(Bayanan Abubuwa masu haɗari)
Guba LD50 na baka a cikin kare:> 1gm/kg

72956-09-3 -Aikace-aikace:

Carvedilol (CAS: 72956-09-03) beta-blocker ne mai vasodilating mai amfani a cikin maganin hauhawar jini da angina pectoris.Bugu da ƙari, rage hawan jini, carvedilol yana rage jimlar juriya na jijiyoyin jini ba tare da tachycardia na reflex yawanci yana faruwa tare da vasodilators.An ba da rahoton cewa an jure shi da kyau tare da tasirin keɓancewar koda.

An fara ƙaddamar da Carvedilol a Belgium a cikin 1985. Wannan samfurin zai iya toshe alpha da beta receptors, babu wani aiki na ciki, a cikin babban taro na salon tare da antagonism na calcium.Yana da tasiri mai ƙarfi na toshe masu karɓar beta, wanda zai iya faɗaɗa tasoshin jini, rage juriya na gefe da rage hawan jini, kuma yana da ɗan tasiri akan fitarwar zuciya da bugun zuciya.Ana iya amfani da asibiti don hauhawar jini na farko da angina pectoris.

72956-09-3 - USP 35 Standard:

BAYANI

Carvedilol ya ƙunshi NLT 98.0% da NMT 102.0% na C24H26N2O4, ƙididdiga akan busasshen tushe.

GANO

• A. Ciwon Infrared <197K>

• B. Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na daidaitaccen bayani, kamar yadda aka samu a cikin Assay.

ASSAY

• Tsari

Buffer: 2.72 g/L na monobasic potassium phosphate.Daidaita tare da dilute phosphoric acid zuwa pH na 2.0.

Lokacin Wayar hannu: Acetonitrile da Buffer (31:69)

Maganin dacewa da tsarin: 0.05 mg/mL kowane na USP Carvedilol RS da USP Carvedilol Related Compound A RS a cikin Waya lokaci

Daidaitaccen bayani: 0.04 mg/mL na USP Carvedilol RS a cikin Wayar hannu

Maganin samfurin: 0.04 mg/mL na Carvedilol a cikin Wayar hannu

Tsarin chromatographic

(Duba Chromatography <621>, Dacewar Tsarin.)

Yanayin: LC

Mai ganowa: UV 240 nm

Tushen: 4.6-mm × 15-cm;5-µm shiryarwa L7

Yanayin zafin jiki: 55 ℃

Yawan gudu: 1 ml/min

Lokacin gudu: 60 min

Girman allura: 10 µL

Dacewar tsarin

Misali: Maganin dacewa da tsarin

Abubuwan da suka dace

Resolution: NLT 4.0 tsakanin carvedilol da carvedilol da alaka fili A

Halin wutsiya: NMT 1.5 don kololuwar carvedilol

Matsakaicin madaidaicin dangi: NMT 2%

Bincike

Samfurori: Daidaitaccen bayani da Samfurin bayani

Yi lissafin adadin carvedilol (C24H26N2O4) a cikin ɓangaren samfurin da aka ɗauka:

Sakamako = (rU/rS) × (CS/CU) × 100

ru =	amsa mafi girma na carvedilol daga samfurin samfurin
rS=	kololuwar amsa na carvedilol daga Standard bayani
CS=	maida hankali na carvedilol a cikin Standard bayani (mg/ml)
KU= ku	Matsakaicin Carvedilol a cikin Maganin Samfurin (mg/mL)

Sharuɗɗan karɓa: 98.0% -102.0% akan busasshen tushe

RASHIN ZUCIYA

• Ragowa akan ƙonewa <281>: NMT 0.1% daga 1 g

• Karfe masu nauyi, Hanyar II <231>: NMT 10 ppm

• Rashin daidaituwa, hanya 1: [bayanin kula da abin da ya dace da shi, aiwatar da ikon kwayar halitta, hanya 2. An ba da shawarar kwayar halitta, hanya 2. An ba da shawarar kwayar halitta, tsari 2.

Lokacin Buffer da Wayar hannu: Shirya kamar yadda aka umarce shi a cikin Assay.

Maganin dacewa da tsarin: 0.05 mg/mL kowane na USP Carvedilol RS da USP Carvedilol Related Compound C RS a cikin Wayar hannu lokaci

Daidaitaccen bayani: 1 µg/mL kowane na USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, da USP Carvedilol Related Compound E RS, da 0.2 μg/ml na USP Carvedil Abubuwan da ke da alaƙa da C RS a cikin lokacin Wayar hannu

Maganin samfurin: 1 MG / ml na Carvedilol a cikin Wayar hannu

Tsarin chromatographic

(Duba Chromatography <621>, Dacewar Tsarin.)

Yanayin: LC

Mai ganowa: Dual wavelength, UV 220 da 240 nm.Yi amfani da 220 nm don ƙididdige abubuwan da ke da alaƙa da carvedilol E, kuma amfani da 240 nm don carvedilol da duk sauran abubuwan da suka shafi.

Tushen: 4.6-mm × 15-cm;5-µm shiryarwa L7

Yanayin zafin jiki: 55 ℃

Yawan gudu: 1 ml/min

Girman allura: 20µL

Dacewar tsarin

Misali: Maganin dacewa da tsarin

Abubuwan da suka dace

Resolution: NLT 17 tsakanin carvedilol da carvedilol da alaka fili C

Bincike

Samfurori: Daidaitaccen bayani da Samfurin bayani

Yi lissafin adadin abubuwan da ke da alaƙa da carvedilol A, fili mai alaƙa da carvedilol B, fili mai alaƙa da carvedilol C, fili mai alaƙa da carvedilol D, fili mai alaƙa da carvedilol E, da duk wani ƙazanta na mutum a cikin ɓangaren Carvedilol da aka ɗauka:

Sakamako = (rU/rS) × (CS/CU) × 100

rU	=	kololuwar martani na mahallin da ke da alaƙa ko duk wani ƙazanta daga Maganin Samfurin
rS	=	kololuwar martani na mahallin da ya dace daga daidaitaccen bayani.Don ƙididdige adadin kowane ƙazanta na kowane mutum yi amfani da kololuwar amsa na carvedilol.
CS	=	maida hankali na daidaitaccen fili mai alaƙa a cikin daidaitaccen bayani (mg/ml).Don ƙididdige adadin duk wani ƙazanta na CS, yi amfani da maida hankali na USP Carvedilol RS.
CU	=	Matsakaicin Carvedilol a cikin Maganin Samfurin (mg/mL)

Sharuɗɗan karɓa: Duba Table 1.

Tebur 1

Suna	Lokacin Tsayawa Dangi	Sharuɗɗan karɓa, NMT (%)
Abubuwan da ke da alaƙa da Carvedilol Ea	0.35	0.1
Abubuwan da suka dace da Carvedilol Ab	0.52	0.1
Abubuwan da ake samu na Carvedilol bisalkylpyrocatechol (idan akwai)c	0.70	0.15
Carvedilol	1.0	-
Abubuwan da suka dace da Carvedilol Cd	3.6	0.02
Abubuwan da ke da alaƙa da Carvedilol De	5.0	0.1
Abubuwan da ke da alaƙa da Carvedilol Bf	8.5	0.1
Duk wani rashin tsarki na mutum	-	0.10
Jimlar ƙazanta	-	0.5g
2- (2-Methoxyphenoxy) ethyl amin. b 1- (4- (2-Hydroxy-3- (2- (2-methoxyphenoxy) ethylamino) propoxy) -9H-carbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2- (2-Methoxyphenoxy) ethylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol). g Yi watsi da duk wani ƙazanta da ke ƙasa da 0.01%.

• Najasa Na Halitta, Hanya na 2

Magani A: Acetonitrile da trifluoroacetic acid (100: 0.1)

Magani B: Trifluoroacetic acid da ruwa (0.1:100)

Diluent: Acetonitrile, trifluoroacetic acid, da ruwa (22:0.1:78)

Lokacin Wayar hannu: Duba Table 2

Table 2

Lokaci (minti)	Magani A (%)	Magani B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Maganin dacewa da tsarin: 1.0 mg/mL na USP Carvedilol Tsarin Dacewar Tsari Tsari RS a cikin Diluent

Maganin samfurin: 1 MG / ml na Carvedilol a cikin Diluent

Tsarin chromatographic

(Duba Chromatography <621>, Dacewar Tsarin.)

Yanayin: LC

Mai ganowa: UV 240 nm

Tushen: 4.6-mm x 15-cm;5-µm shiryarwa L68

Yanayin zafin jiki: 30 ℃

Yawan gudu: 1.4ml/min

Girman allura: 20µL

Dacewar tsarin

Misali: Maganin dacewa da tsarin

Abubuwan da suka dace

Resolution: NLT 1.8 tsakanin carvedilol da carvedilol da alaka fili F

Bincike

Misali: Misalin bayani

Yi ƙididdige adadin kowane ƙazanta a cikin ɓangaren Carvedilol da aka ɗauka:

Sakamako = (rU/rT) × 100

rU	=	kololuwar amsa ga kowane ƙazanta a cikin Samfurin bayani
rT	=	jimlar duk kololuwar martani a cikin Sample bayani

Sharuɗɗan karɓa: Duba Table 3.

Table 3

Suna	Dan uwa Riƙewa Lokaci	Karba Ma'auni, NMT (%)
Abubuwan da suka dace da Carvedilol Aa	0.7	0.1
Carvedilol	1.0	-
Abubuwan da ke da alaƙa da Carvedilol Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Abubuwan da suka dace da Carvedilol Ce	1.8	0.02
Abubuwan da ke da alaƙa da Carvedilol Bf	2.1	0.1
Biscarbazoleg	3	0.1
Duk wani rashin tsarki na mutum	-	0.1
Jimlar ƙazanta	-	0.5
a 1- (4- (2-Hydroxy-3- (2- (2-methoxyphenoxy) ethylamino) propoxy) -9Hcarbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2-ol . b 1- (2- (2-Methoxyphenoxy) ethylamino) -3- (6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol. c Ana ƙididdige wannan ƙazanta ta hanyar amfani da hanyar ƙarƙashin Tsarin Nazari, Tsari na 3: Haɗin Haɗin Carvedilol F. d 1- (H-Carbazol-4-yloxy) -3-[2- (2-methoxyphenoxy) ethyl] N-isopropylamino] -2-propanol. e 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol. f 3,3'-(2- (2-Methoxyphenoxy) ethylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol.

• Najasa Na Halitta, Hanya na 3: Abubuwan da ke da alaƙa da Carvedilol F (idan akwai)

Magani A: Trifluoroacetic acid da ruwa (0.5:100)

Magani B: methanol da trifluoroacetic acid (100: 0.5)

Diluent: Ruwa da acetonitrile (1: 1)

Zaman Waya: Magani A da Magani B (65:35)

Maganin dacewa da tsarin: 1.5 mg/mL na USP Carvedilol Tsarin Dacewar Tsari Tsari RS a cikin Diluent

Maganin samfurin: 1.5 mg / ml na Carvedilol a cikin Diluent an shirya kamar haka.Yi amfani da kusan 1.9 ml na Diluent da MG na Carvedilol, da sonicate a taƙaice don sauƙaƙe narkewa.

Tsarin chromatographic

(Duba Chromatography <621>, Dacewar Tsarin.)

Yanayin: LC

Mai ganowa: UV 226 nm

Tushen: 4.6-mm × 30-mm;3-µm shiryarwa L7

Yanayin zafin jiki: 40 ℃

Yawan gudu: 2 ml/min

Girman allura: 10 µL

Dacewar tsarin

Misali: Maganin dacewa da tsarin

Abubuwan da suka dace

Resolution: NLT 2.0 tsakanin carvedilol da carvedilol da alaka fili F

Bincike

Misali: Misalin bayani

Yi ƙididdige adadin abubuwan da ke da alaƙa da carvedilol F a cikin ɓangaren samfurin da aka ɗauka:

Sakamako = (rU/rT) × (1/F) × 100

rU	=	kololuwar martani na fili mai alaƙa da carvedilol F daga Maganin Samfurin
rT	=	jimlar mafi girman martanin carvedilol da carvedilol mai alaƙa da fili F daga Maganin Samfurin
F	=	Matsayin amsawar dangi, 1.1

Sharuɗɗan karɓa: NMT 0.1%

MAKAMMAN JARRABAWA

• Asarar bushewa <731>: Dry samfurin a 105 ℃ na 3 h: yana rasa NMT 0.5% na nauyinsa.

KARIN BUKATA

• Marufi da Ajiye: Ajiye a cikin matsugunan kwantena, kuma adana a zazzabin ɗaki mai sarrafawa.

• Lakabi: Idan an yi amfani da gwajin gurɓataccen ƙwayar cuta ta HPLC ban da tsari na 1, to, alamar ta faɗi gwajin da labarin ya bi.

• Matsayin Magana na USP <11>

USP Carvedilol RS

Abubuwan da ke da alaƙa da USP Carvedilol A RS
1- (4- (2-Hydroxy-3-------------- ol.
C36H43N3O7 629.74

USP Carvedilol Abubuwan da ke da alaƙa B RS
3,3' (2- (2-Methoxyphenoxy) ethylazanediyl) bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Abubuwan da ke da alaƙa da C RS
1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol.
C31H32N2O4 496.60

Abubuwan da ke da alaƙa da USP Carvedilol D RS
4- (Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27

Abubuwan da ke da alaƙa da USP Carvedilol E RS
2- (2-Methoxyphenoxy) ethyl amin.
C9H13NO2 167.21

USP Carvedilol Tsarin Dacewar Canjin Canjin RS
Cakuda kusan 0.1% carvedilol mai alaƙa da fili F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) a cikin matrix na carvedilol miyagun ƙwayoyi abu.