Risperidone CAS 106266-06-2 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na Risperidone (CAS: 106266-06-2) tare da babban inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Risperidone,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | Risperidone |
| Makamantu | 3-[2-[4- (6-Fluoro-1,2-Benzisoxazol-3-yl) -1-Piperidinyl] -6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1] ,2-a]pyrimidin-4-daya;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 106266-06-2 |
| Tsarin kwayoyin halitta | Saukewa: C23H27FN4O2 |
| Nauyin Kwayoyin Halitta | 410.49 g/mol |
| Matsayin narkewa | 170.0 zuwa 174.0 ℃ |
| Yawan yawa | 1.38± 0.10 g/cm3 |
| Matsayin Hazard | 6.1;Guba |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Alamar | Ruifu Chemical |
| Abubuwa | Ƙayyadaddun bayanai | Sakamako |
| Bayyanar | Fari zuwa Kashe-Farin Foda | Ya bi |
| Identification A | Infrared Absorption | Ya bi |
| Identity B | Lokacin Tsayawa: Yayi daidai da Abun Magana | Ya bi |
| Asara akan bushewa | <0.50% | 0.12% |
| Ragowa akan Ignition | <0.10% | 0.07% |
| Karfe masu nauyi | <0.001% | <0.001% |
| Abubuwan da ke da alaƙa | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Duk wani rashin tsarkin da ba a sani ba | <0.10% | <0.10% |
| Jimlar ƙazanta | <0.30% | <0.30% |
| Assay | 98.0 ~ 102.0% (Lissafi akan Busassun Tushen) | 100.52% |
| Kammalawa | An gwada samfurin kuma ya bi ka'idodin USP 35 | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido [1,2-a] pyrimidin-4-daya, 3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) -1-piperidinyl] ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-daya [106266-06-2].
» Risperidone ya ƙunshi bai wuce kashi 98.0 ba kuma bai wuce kashi 102.0 na C23H27FN4O2 ba, wanda aka lissafta akan busasshen tushe.
Marufi da ajiya - Ajiye a cikin kwantena da aka rufe sosai.Ajiye a zafin jiki.
Matsayin Magana na USP <11>-
USP Risperidone RS
3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-daya 410.48 CAS-106266-06-2
USP Risperidone Tsarin Dacewar Tsari Tsari RS
Ya ƙunshi risperidone da kusan 0.2% na kowane ɗayan masu zuwa:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-daya.
9-Hydroxyrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-daya.
6-Methylrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-daya.
[Lura-Wannan cakuda ya ƙunshi risperidone, Z-oxime, 9-hydroxyrisperidone, da 6-methylrisperidone.]
Ganewa-
A: Ciwon Infrared <197K>.
B: Lokacin riƙewa na babban kololuwa a cikin chromatogram na shirye-shiryen Assay ya dace da abin da ke cikin chromatogram na daidaitaccen shiri, kamar yadda aka samu a cikin Assay.
Asarar bushewa <731> - Dry a cikin injin a 80 na tsawon sa'o'i 4: ya rasa fiye da 0.5% na nauyinsa.
Ragowa akan kunnawa <281>: bai wuce 0.1% ba, ana amfani da samfurin gwajin 2.0-g.
Karfe masu nauyi, Hanyar II <231>: 0.001%.
Abubuwan da ke da alaƙa-
Maganin buffer, Magani A, Magani B, Wayar hannu, Diluent, Maganin dacewa da tsarin, da tsarin Chromatographic-Shirya kamar yadda aka umurce a cikin Assay.
Daidaitaccen bayani-Yi amfani da daidaitaccen shiri, wanda aka shirya kamar yadda aka umurce shi a cikin Assay.
Maganin gwaji-Yi amfani da shirye-shiryen Assay.
Tsari-allurar daidaitattun juzu'i (kimanin 10 µL) na daidaitaccen bayani da maganin Gwaji a cikin chromatograph, da yin rikodin chromatogram.Gano ƙazanta ta amfani da lokutan riƙewar dangi da aka bayar a cikin Tebur 1, kuma auna mafi girman martani.Yi ƙididdige adadin kowane fili mai alaƙa da risperidone a cikin ɓangaren Risperidone da aka ɗauka ta dabara:
100 (CS / CU) (rU / rS) (1/F)
a cikin abin da CS da CU sune ƙididdiga, a cikin mg da ml, na risperidone a cikin Ma'auni na Ma'auni da gwajin gwajin bi da bi;rU shine mafi girman yanki na kowane ƙazanta da aka samu daga maganin gwajin;rS shine yanki kololuwar risperidone da aka samu daga Madaidaicin bayani;kuma F shine yanayin amsa dangi ga kowane ƙazanta dangane da risperidone.Baya ga rashin ƙetare iyaka a cikin Teburin 1, bai wuce 0.10% na kowane ƙazanta da ba a san shi ba (amfani da ƙimar F na 1.0) kuma ba a sami sama da 0.30% na ƙazantar gaba ɗaya ba.Yi watsi da kololuwar ƙazanta waɗanda ba su kai 0.05%.
Tebur 1
Mahimmancin Haɗin Dangantakar Lokacin Riƙewa (RRT) Iyakar Amsa Na Dangi (F) (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4- (E) (2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a] pyrimidin-4-daya
2 3-[2-[4- (Z) (2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a] pyrimidin-4-daya
3 (9RS) -3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a] pyrimidin-4-daya
4 3-[2-[4- (5-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-daya
5 (6RS) -3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a] pyrimidin-4-daya
Assay-
Maganin buffer- Narke 15.4 g na ammonium acetate a cikin 1 L na ruwa.Daidaita tare da 10% acetic acid zuwa pH na 6.5, kuma haɗuwa.
Magani A-Haɗa 100 ml na Maganin Buffer tare da 150 ml na methanol a cikin 1000-mL volumetric flask, kuma tsarma da ruwa zuwa girma.
Magani B- Mix 100 ml na buffer bayani tare da 850 ml na methanol a cikin 1000-mL volumetric flask, kuma tsarma da ruwa zuwa girma.
Lokacin wayar hannu-Yi amfani da gauraya masu canji na Magani A da Magani B kamar yadda aka umurce su don tsarin Chromatographic.Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography 621).
Diluent-Haɗa 100 ml na maganin buffer tare da 900 ml na ruwa da 1000 ml na methanol.
Maganin dacewa da tsarin-Shirya 1 MG a kowace ml na USP Risperidone Tsarin Dacewar Tsari Tsari RS a cikin Diluent.
Daidaitaccen shiri-Narkar da adadin USP Risperidone RS daidai gwargwado a cikin Diluent, kuma a tsarke ƙima, da mataki-mataki idan ya cancanta, tare da Diluent don samun mafita yana da sananniya na kusan 1.0 MG kowace ml.
Shirye-shiryen Assay-Narke daidaitaccen adadin Risperidone a cikin Diluent, kuma a tsoma shi da yawa, da mataki-mataki idan ya cancanta, tare da Diluent don samun maganin yana da kusan 1.0 MG kowace ml.
Tsarin Chromatographic (duba Chromatography <621>) - chromatograph na ruwa yana sanye da na'urar ganowa 275-nm da ginshiƙi 4.6-mm × 10-cm wanda ya ƙunshi 3-µm tattara L1.Matsakaicin kwarara shine kusan 1.5 ml a minti daya.Ana kiyaye zafin jiki na ginshiƙi a 35. An tsara chromatograph kamar haka.
Lokaci (minti) Magani A (%) Magani B (%) Elution
0-1 70 30 masu zaman kansu
1–20 70®5 30®95 layin layi
20-25 5 95 masu tsattsauran ra'ayi
25–27 5®70 95®30 layin layi
27-35 70 30 sake daidaitawaInject da tsarin dacewar tsarin.Yi rikodin amsawar kololuwa kamar yadda aka tsara don Tsarin tsari, kuma gano kololuwa saboda Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, da risperidone ta amfani da lokutan riƙewa na dangi (RRT) daga Table 1;ƙuduri, R, tsakanin Z-oxime da 9-hydroxyrisperidone ba kasa da 2.8;Halin wutsiya na risperidone bai wuce 1.5 ba;kuma madaidaicin ma'auni na dangi don kwafin injections bai wuce 2.0% ba don kololuwar risperidone.
Tsari- Na dabam allura daidai juzu'i (kimanin 10 µL) na daidaitaccen shiri da shirye-shiryen Assay a cikin chromatograph, kuma auna martani ga kololuwar risperidone.Yi ƙididdige adadin, a cikin kashi na C23H27FN4O2, a cikin ɓangaren Risperidone da aka ɗauka ta dabara:
100 (CS / CU) (rU / rS)
a cikin abin da CS da CU suke da yawa, a cikin MG da ml, na risperidone a cikin Shirye-shiryen Daidaitawa da Shirye-shiryen Assay, bi da bi;da rU da rS sune mafi girman martanin da aka samu daga shirye-shiryen Assay da Daidaitaccen shiri, bi da bi.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Bayanan Bayani na UN3249
WGK Jamus 3
Saukewa: RTECS UV1164800
Lambar 2934999099
Matsayin Hazard 6.1(a)
Rukunin tattarawa II
Risperidone (CAS: 106266-06-2) yana da tasirin antagonism akan masu karɓar 5HT2 da masu karɓa na D2.Ana amfani da Risperidone don schizophrenia mai tsanani da na kullum.Magungunan antipsychotic.Ana amfani da Risperidone don maganin schizophrenia mai tsanani da na yau da kullum da sauran nau'o'in psychotic daban-daban bayyanannun alamun bayyanar cututtuka (kamar hallucinations, ruɗi, rikicewar tunani, ƙiyayya, zato) da kuma manyan alamun bayyanar cututtuka (kamar rashin amsawa, rashin tausayi da rashin tausayi na zamantakewa, na 'yan kaɗan). kalmomi).Hakanan yana iya rage tasirin bayyanar cututtuka masu alaƙa da schizophrenia (kamar: baƙin ciki, laifi, damuwa).Ga marasa lafiya wanda Risperidone ke da tasiri ga magani mai mahimmanci, a cikin lokacin kulawa na jiyya, Risperidone na iya ci gaba da yin tasiri na asibiti.Risperidone, sabili da haka, yana da aikin warkewa akan duka tabbatacce da kuma mummunan bayyanar cututtuka na schizophrenia kuma yana haifar da ƙarancin sakamako masu illa musamman bayyanar cututtuka na extrapyramidal idan aka kwatanta da waɗanda aka saba amfani da su tsarkakakkun antagonist antipsychotics D2.Hakanan yana da yuwuwar sarrafa cire barasa da jarabar hodar iblis.
