Vardenafil Matsakaici CAS 224789-21-3 Tsarkake>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na 2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F] [1,2,4]triazin-4 (3H) -daya (CAS: 224789-21-3) tare da babban inganci, matsakaici na Vardenafil.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | 2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F][1,2,4]triazin-4 (3H) -daya |
| Makamantu | Vardenafil Dessulfonyl rashin tsabta;2- (2-Ethoxyphenyl) -5-Methyl-7-Propyl-3H-Imidazo [5,1-F] [1,2,4]triazin-4-daya;Vardenafil Propyl Imidazotriazinone rashin tsabta;Abubuwan da suka danganci Vardenafil 1 |
| Matsayin Hannun jari | A Hannun jari, Iyawar Samar da Ton 2 a kowane wata |
| Lambar CAS | 224789-21-3 |
| Tsarin kwayoyin halitta | Saukewa: C17H20N4O2 |
| Nauyin Kwayoyin Halitta | 312.37 g/mol |
| Matsayin narkewa | 142.0 ~ 148.0 ℃ |
| Yawan yawa | 1.26± 0.10 g/cm3 |
| Adana Tsawon Lokaci | Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃) |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Alamar | Ruifu Chemical |
| Abubuwa | Ƙayyadaddun bayanai | Sakamako |
| Bayyanar | Kashe-Fara zuwa Kodiddigar Foda | Kashe-Farin Foda |
| Matsayin narkewa | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Asara akan bushewa | <1.00% (102 ℃, 3h) | 0.23% |
| Karfe masu nauyi (Pb) | ≤20ppm | <20ppm |
| Tsarkake / Hanyar Bincike | > 99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | Daidai da Tsarin | Ya bi |
| Kammalawa | An gwada samfurin kuma ya dace da ƙayyadaddun da aka bayar | |
| Aikace-aikace | Matsakaicin Vardenafil / Vardenafil Hydrochloride | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga hasken rana da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
1. Bayyanar: Saka samfurin a kan farar takarda kuma kula da bayyanar, kashe-fari zuwa kodadde rawaya foda.
2. Nazari:
2.1 Ƙididdigar wurin narkewa bisa ga doka (Pharmacopoeia na China 2010 Edition II Shafi ⅥC) Matsayin narkewa shine 142.0 ~ 148.0℃.
2.2 Asara akan bushewa: Ƙaddara bisa ga doka (Shafi ⅧL, Sashe na II, 2010 Edition of Chinese Pharmacopoeia).Ma'auni daidai adadin wannan samfurin, bushe a 102 ℃ na 3 hours, nauyi asara ba zai zama fiye da 1.00%.
2.3 Nauyin Karfe: Ƙaddara bisa doka (Jamhuriyar Jama'ar Sin Pharmacopoeia 2010 Edition, Sashe na II Shafi ⅧH) Ƙaddara ta hanya ta biyu.
Daidaitaccen nauyin 1.0g na samfurin gwajin, a hankali yana ƙonewa har sai da carbonated, sanyi, ƙara 0.5-1.0ml sulfuric acid, sanya shi m, zafi a ƙananan zafin jiki har sai sulfuric acid ya ƙare, ƙara 0.5ml nitric acid, tururi bushe, har sai Tushen nitrogen oxide ya ƙare, sanyi, zafi a 500-600 ℃ zuwa gaba ɗaya carbonized, sanyi, ƙara 2ml hydrochloric acid, Bayan bushewa a cikin wanka na ruwa, ƙara ruwa 15ml, sauke maganin gwajin ammonia har sai ya zama tsaka tsaki ga alamar phenolphthalein. bayani, ƙara 2ml acetate buffer (ph3.5), kuma zafi kadan narke, matsar da shi zuwa bututun launi na Nachner, kuma a tsoma shi cikin 25ml da ruwa.Ɗauki wani reagent don shirya maganin gwajin, da kuma tururi shi a cikin wani kwanon rufi, ƙara 2ml acetate buffer (PH3.5) da 15ml ruwa zuwa dan kadan zafi Bayan rushewa, matsar da Nath colorimetric tube, ƙara wani adadin daidaitaccen maganin gubar, sannan a tsomasu da ruwa zuwa 25ml.Ana yin gwajin launin launi tsakanin maganin gwaji da daidaitaccen bayani don samu.Daidaitaccen shiri na mafita bisa ga (Jamhuriyar Jama'ar Sin Pharmacopoeia 2010 bugu II Shafi Ⅷ Hanyar gwajin ƙarfe mai nauyi) hanya ta farko.Karfa masu nauyi kada su wuce kashi 20 a kowace miliyan.
3. Tsafta: Dangane da babban aikin ruwa chromatography, ƙaddara bisa ga doka (Pharmacopoeia na Sinanci 2010 bugu II Karin Bayani VD).
Yanayi na chromatographic:
Tushen: C18, 200mm × 4.6mm, 5μm;
Lokacin wayar hannu: Buffer Phosphate (nauyin 2.72g potassium dihydrogen phosphate, ƙara ruwa don narkewa da tsarma zuwa 1000ml, daidaita pH = 3.5) : acetonitrile: = 35: 65;
Tsawon tsayin tsinkaya: 254nm;
Yawan gudu: 1.0ml/min.
Hanyar ƙaddara: Ɗauki kimanin 30mg na wannan samfurin, auna shi daidai, tsoma shi da lokacin wayar hannu don yin taro na kusan 0.3mg/ml, ɗauki 20μl a cikin chromatograph na ruwa, yin rikodin chromatogram.Dangane da hanyar daidaita yanayin yanki, tsabtar ba ta ƙasa da 99.0%.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Tsarin al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F] [1,2,4]triazin-4 (3H) -daya (CAS: 224789-21-3) shine matsakaici na Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil wani sabon mai hana PDE5 ne wanda aka kaddamar don maganin maganin rashin lafiyar namiji kuma yana da mahimmancin tsarin kama da sildenafil (Viagra), wanda shine farkon PDE5 mai hanawa wanda aka gabatar a 1998 don wannan nuni.
Vardenafil shi ne wakili na biyu da za a sayar da shi kuma yana da fa'ida cewa ba a rage lokacin farawa ta hanyar shan magani a cikin cikakken ciki ba.Yana da sau 30 mafi ƙarfi a matsayin mai hanawa na PDE5 (ma'anar IC50, 3.9 nM) fiye da sildenafil da 10 sau da yawa fiye da tadalafil, tare da zaɓi mafi girma (> 1,000 sau) don PDE5 na ɗan adam fiye da PDE2, PDE3, da PDE4 da matsakaicin zaɓi (> sau 80) don PDE1.Zaɓin inhibitory PDE da duka in vitro da in vivo ƙarfin sabon PDE5 inhibitor vardenafil.Vardenafil musamman ya hana hydrolysis na cGMP ta PDE5, tare da IC50 na 0.7 nM (sildenafil 6.6 nM).IC50 na vardenafil don PDE1 shine 180 nM, don PDE6 11 nM, kuma don PDE2, PDE3 da PDE4 fiye da 1,000 nM.
