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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate tsarki ≥99.0% (HPLC)
Ruifu Chemical shine babban mai samar da Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) tare da babban inganci, matsakaici na Apixaban (CAS: 503612-47-3).Ruifu na iya samar da isar da saƙo na duniya, farashi mai gasa, ƙanana da yawa da ake samu.Sayi masu tsaka-tsaki na Apixaban, imel: alvin@ruifuchem.com
| Sunan Sinadari | Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate |
| Makamantu | Ethyl 2-Chloro-2-[2- (4-Methoxyphenyl) hydrazono] acetate;(Z) - Ethyl 2-Chloro-2- (2- (4-Methoxyphenyl) hydrazono) acetate;2-Chloro-2-[2- (4-Methoxyphenyl) hydrazinylidene];Apixaban-2;Apixaban rashin tsarki 3 |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 27143-07-3 |
| Tsarin kwayoyin halitta | Saukewa: C11H13ClN2O3 |
| Nauyin Kwayoyin Halitta | 256.69 g/mol |
| Matsayin narkewa | 94 ℃ |
| Yawan yawa | 1.23 |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Kashi | Matsakaicin Apixaban (CAS: 503612-47-3) |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Rawaya Mai Haske zuwa Foda Rawaya | Ya bi |
| Asara akan bushewa | <0.50% | 0.23% |
| Tsarkake / Hanyar Bincike | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Yayi daidai da Tsarin | Ya bi |
| 1 H NMR Spectrum | Daidai da Tsarin | Ya bi |
| Kammalawa | An gwada samfurin kuma ya bi ƙayyadaddun da aka bayar | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Jerin Maganganun da Aka Yi Amfani da su a Masana'antu
| A'a. | Suna | CAS No. | Tsarin kwayoyin halitta |
| 1 | Ethyl acetate | Saukewa: 141-78-6 | Saukewa: C4H8O2 |
| 2 | Dichloromethane | Saukewa: 75-09-2 | Saukewa: CH2Cl2 |
| 3 | Ethyl Alcohol | Saukewa: 64-17-5 | C2H5OH |
5.3.1 Bayyanar: Ya kamata ya zama haske rawaya zuwa rawaya foda.A gani, sanya isassun samfuran gwaji (ba tare da aunawa ba) a cikin tsaftataccen tasa mai kristal akan farar bango (kamar farar takarda) ƙarƙashin hasken halitta.
5.3.2 Identification: 1H-NMR yana da tsari iri ɗaya da ma'auni.10 ~ 15mg na samfurin an auna shi a cikin bututun maganadisu na nukiliya, kuma an ƙara 0.5mL na deuterium DMSO don narkar da samfurin gabaɗaya, sa'an nan kuma an gwada shi tare da kayan aikin maganadisu na nukiliya fiye da 400MHz.
5.3.3 Asarar bushewa: Auna samfurin game da 1.0g kuma bushe shi don 3h a cikin tanda bushewa a 85 ℃.Za a yi takamaiman aiki don lissafin asarar nauyi bisa ga tanadi na SOP-AP-QC-002-01 don Ƙaddamar da Rage Nauyin bushewa.
5.3.4.1 Yanayi na chromatographic:
Reagents na gwaji: 1) acetonitrile don chromatography 2) ruwa mai tsafta 3) phosphoric acid
Tushen: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Wayar hannu lokaci: A: Daidai auna 1.0ml phosphoric acid da 1000ml ruwa, tace ultrasonic degassing.
B: Acetonitrile.
Hanyar gradient: tebur mai zuwa
Lokacin Wayar hannu Fasin A (%) Wayar hannu Matakin B (%)
390 10
1025 75
200 100
250 100
Mai ganowa: 210nm
Yanayin zafin jiki: 35 ℃
Gudun gudu: 1.0ml/min
Girman samfurin: 5µl
5.3.4.2 Shirye-shiryen Magani:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Maganin blank: diluent za a yi amfani dashi azaman bayani mara kyau.
5.3.4.5 Maganin samfurin gwaji: Yi la'akari da samfurin gwajin game da 12.5mg a cikin kwalban volumetric na 25ml kuma narke shi tare da diluent zuwa sikelin.
5.3.4.6 Hanyar Aiki: Bayan tushen tushen kayan aikin ya tsaya tsayin daka, ana ci gaba da allura ɗaya zuwa biyu na bayani mara kyau, sannan ana nazarin maganin samfurin gwajin.An adana chromatogram kuma an bincika, an cire kololuwa mara kyau, kuma babban tsaftar kololuwa da sakamakon ƙazanta ɗaya akan chromatogram na samfurin gwajin ana yin rikodin ta hanyar daidaita yanayin yanki.Bayan binciken, an buga chromatogram.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Tsarin al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) ana amfani dashi azaman tsaka-tsaki a cikin kira na Apixaban (CAS: 503612-47-3).Apixaban wani sabon nau'in factor factor Xa inhibitor tare da Bristol-Myers Squibb da Pfizer suka haɓaka.Sunan kasuwancin Erroto.Wani sabon nau'in maganin ciwon ciki ne na baka.Ta hanyar hana wani muhimmin coagulation factor Xa, apixaban zai iya hana thrombin samar da thrombosis.Bristal-Myers squibb Company ne ya haɓaka Apixaban.Yana da kyau bioavailability da high selectivity.An jera shi a cikin kasar Sin a cikin 2013. Apixaban yana da lafiya, yiwuwar hulɗar miyagun ƙwayoyi kadan ne, kuma akwai hanyoyi da yawa don kawar da shi, wanda ake sa ran za a yi amfani da shi a cikin kungiyoyi na musamman masu fama da ciwon hanta ko lalacewar aikin koda.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate tsarki ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
