CAS 361442-04-8 Tsabta > 99.0% (HPLC) API Featured Hoton

CAS 361442-04-8 Tsarkake>99.0% (HPLC) API

Takaitaccen Bayani:

Synonyms: BMS-477118;Onglyza

Saukewa: 361442-04-8

Tsafta:> 99.0% (HPLC)

Bayyanar: Farin Foda

API, Babban inganci, Samar da Kasuwanci

E-Mail: alvin@ruifuchem.com

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Cikakken Bayani

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Bayani:

Ruifu Chemical Supply Intermediates
Saukewa: CAS361442-04-8
Saukewa: CAS945667-22-1
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(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2- (3-Hydroxy-1-Adamantyl) -2-Oxoacetic Acid CAS 709031-28-7

Abubuwan Sinadarai:

Makamantu	BMS-477118;Onglyza;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo[3.1.0] hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7] dec-1-yl) acetyl]-2-Azabicyclo[3.1.0] hexane -3-Carbonitrile
Lambar CAS	361442-04-8
Lambar CAT	Saukewa: RF-PI1991
Matsayin Hannun jari	A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton
Tsarin kwayoyin halitta	Saukewa: C18H25N3O2
Nauyin Kwayoyin Halitta	315.41
Alamar	Ruifu Chemical

Ƙayyadaddun bayanai:

Abu	Ƙayyadaddun bayanai
Bayyanar	Farin Foda
wari	Halaye
ganewa	A: IR B: Lokacin Riƙewar HPLC
Tsarkake / Hanyar Bincike	> 99.0% (HPLC)
Bayyanar Maganin Ruwa	M, Mara Launi, Babu Wani Dakatar da Al'amura
Binciken Sieve	100% Wuce 80 Mesh
Matsayin narkewa	202.0 ~ 212.0 ℃
Asara akan bushewa	<0.50%
Sulfate ash	<0.20%
Takamaiman Juyawa	+174.0°~+186.0°
Tsaftace Guda Daya	<0.50%
Jimlar ƙazanta	<1.00%
Karfe masu nauyi	<10ppm
Arsenic (AS)	<2.0pm
Jagora (Pb)	<1.0pm
Cadmium (Cd)	<1.0pm
Ragowar Magani	<100ppm
Ragowar maganin kashe qwari	Korau
Microbiology
Jimlar Ƙididdigar Faranti	<1000cfu/g
Yisti & Mold	<100cfu/g
E. Coli	Korau
S. Aure	Korau
Salmonella	Korau
Rayuwar Rayuwa	Watanni 24 Daga Ranar Ƙirƙira Idan An Ajiye shi Da kyau
Matsayin Gwaji	Matsayin Kasuwanci
Amfani	API;Nau'in ciwon sukari na 2

Kunshin & Ajiya:

Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata

Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi

Amfani:

FAQ:

Aikace-aikace:

(BMS-477118) (CAS: 361442-04-8) mai ƙarfi ne, zaɓaɓɓe, mai jujjuyawa, gasa da magana dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) mai hanawa.BMS-477118 yana da peotential don nau'in ciwon sukari na 2 na bincike.Saukewa: BMS-477118magani ne na nau'in ciwon sukari na 2 wanda zai iya motsa pancreas don samar da ƙarin insulin bayan cin abinci.An kai shi ta hanyar haɗin gwiwar AstraZeneca da Kamfanin Bristol-Myers Squibb kuma yana cikin mai hana DPP-IV.Saukewa: BMS-477118yana taka rawar ta hanyar hana lalata GLP-l.GLP-I shine hormones da aka samar a cikin hanji bayan cin abinci.Yana iya daidaita fitar da insulin da ƙarfafa amfani da glucose a cikin kyallen takarda.Magani guda ɗaya na BMS-477118 na iya inganta sarrafa glucose na jini da haɗin gwiwar magani na BMS-477118 tare da Metformin, Sulfonylurea da Thiazolidinediones na iya haɓaka tasirin warkewa.Yana haifar da ƙananan haɗarin hypoglycemia kuma mummunan halayensa suna kama da placebo, yana nuna mafi kyawun haƙuri.31 ga Yuli, 2009, BMS-477118 Allunan (Onglyza), sabon magani na nau'in ciwon sukari na 2, tare da bincike da haɓaka AstraZeneca da Bristol-Myers Squibb FDA ta Amurka ta amince da su.Ana iya shan sau ɗaya a rana don magance nau'in ciwon sukari na 2 tare da sarrafa Abinci da motsa jiki.