TMC207 CAS 843663-66-1 Tsafta > 99.5% (HPLC)
Matsakaici masu dangantaka TMC207:
Saukewa: TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Sunan Sinadari | Saukewa: TMC207 |
| Makamantu | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α- [2- (dimethylamino) ethyl] -2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1- (6-Bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2- (1-naphthyl) 2-butanol |
| Lambar CAS | 843663-66-1 |
| Lambar CAT | Saukewa: RF2336 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C32H31BrN2O2 |
| Nauyin Kwayoyin Halitta | 555.516 |
| Matsayin narkewa | 104 ℃ |
| Yawan yawa | 1.322± 0.06 g/cm3 |
| M | Hygroscopic.Hasken Hankali, Mai Aiki na iska |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari ko Kashe-Farin Foda |
| Tsarkake / Hanyar Bincike | > 99.5% (HPLC) |
| Asara akan bushewa | <0.50% |
| Ragowa akan Ignition | <0.20% |
| Duk wani Rashin Tsabtace Mutum | <0.10% |
| Isomer | <0.10% |
| Jimlar ƙazanta | <0.50% |
| Karfe masu nauyi (kamar Pb) | <20ppm |
| Arsenic (AS) | <2.0pm |
| Infrared Spectrum | Yayi daidai da Tsarin |
| Abubuwan da aka bayar na Proton NMR Spectrum | Yayi daidai da Tsarin |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | API |
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(CAS: 843663-66-1), (wanda aka sani da TMC207 da R207910), wanda aka yi ciniki a ƙarƙashin sunan kasuwanci Sirturo, wani labari ne na diarylquinoline antimycobacterial magani wanda ke shafar tarin fuka ta hanyar hana ayyukan M. tuberculosis ATP synthase proton famfo.Haɗin ATP na mycobacteria yana haifar da ƙwayoyin cuta da ƙwayoyin cuta.An yi amfani da shi na asibiti don magance cutar tarin fuka mai jure wa manya (MDR-PTB).TMC207 yana da aiki iri ɗaya na ƙwayoyin cuta a kan M. tarin fuka m damuwa da kuma juriya iri, kuma yana da kyau haifuwa sakamako a kan dormant kwayoyin.A cikin Disamba 2012, FDA ta Amurka ta amince da TMC207 a matsayin wani ɓangare na maganin haɗin gwiwa don maganin tarin fuka mai jure wa miyagun ƙwayoyi (MDRTB).TMC207 shine magani na farko da aka amince da shi don MDR-TB kuma shine amincewa na farko daga sabon nau'in maganin tarin fuka a cikin shekaru 40 da suka gabata.Saboda babban buƙatun rashin lafiya don magance MDR-TB, FDA ta ba TMC207 saurin amincewa bisa sakamakon Mataki na II, yana ba marasa lafiya damar yin amfani da magungunan yayin da ake gudanar da ƙarin karatun asibiti.TMC207 diarylquinoline ne wanda aka gano daga babban aiki, dabarun tantancewa gabaɗayan tantanin halitta tare da Mycobacterium smegmatis da aka yi amfani da shi azaman maye gurbin M. tarin fuka.TMC207 shine mai haɓakawa guda ɗaya na bugun allo na farko.TMC207 yana da aiki mai ƙarfi da zaɓi a kan mycobacteria, kuma yana aiki da duka-magungunan-magunguna da masu jurewar ƙwayar cuta M. tarin fuka.Tsarin aikin TMC207 na musamman ne a tsakanin magungunan rigakafin tarin fuka kuma ya haɗa da hana ƙwayoyin cuta na ATP synthase;ba ya aiki a kan ɗan adam ATP synthase.TMC207 yana aiki a cikin vivo a cikin nau'ikan nau'ikan kamuwa da cutar tarin fuka, shi kaɗai kuma a haɗe tare da sauran magungunan rigakafin tarin fuka, kuma yana da ayyukan ƙwayoyin cuta a cikin ingantattun samfuran kamuwa da tarin fuka.An haɗa TMC207 a cikin matakai biyar daga 3-Phenylpropionic Acid da para-Bromoaniline.Bayan samuwar amide, jiyya tare da POCl3 da DMF ƙarƙashin yanayin Vilsmeier-Hack ya ba da samfurin 2-Chloroquinoline.Jiyya tare da sodium methoxide, wanda ya biyo baya tare da 3- (Dimethylamino) -1- (naphthalen-1-yl) propan-1-one, da rabuwa na isomers ya ba TMC207.
