Crizotinib Intermediate CAS 877399-00-3 Tsabtace ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na (R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] pyridin-2-Amine (CAS: 877399-00) -3) tare da babban inganci, matsakaici na Crizotinib (CAS: 877399-52-5).Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | (R)-5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Makamantu | Crizotinib Intermediate;Crizotinib Bromide rashin tsabta;5-Bromo-3-[(1R) -1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] -2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amin |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 877399-00-3 |
| Tsarin kwayoyin halitta | Saukewa: C13H10BrCl2FN2O |
| Nauyin Kwayoyin Halitta | 380.04 g/mol |
| Matsayin narkewa | 108.0 zuwa 113.0 ℃ |
| Yawan yawa | 1.643 |
| COA & MSDS | Akwai |
| Misali | Akwai |
| Asalin | Shanghai, China |
| Kashi | Matsakaicin Crizotinib (CAS: 877399-52-5) |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Rawaya Mai Haske Zuwa Foda Rawaya zuwa Crystal | Ya bi |
| Matsayin narkewa | 108.0 zuwa 113.0 ℃ | Ya bi |
| Tsaftace (Yankin HPLC) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | Yayi daidai da Tsarin | Ya bi |
| 1 H NMR Spectrum | Yayi daidai da Tsarin | Ya bi |
| Kammalawa | An gwada wannan samfurin kuma ya dace da ƙayyadaddun bayanai | |
| Rayuwar Rayuwa | Shekaru 2 Idan An Ajiyesu Da Kyau | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Haɗin Kan Al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] pyridin-2-Amine (CAS: 877399-00-3) ana amfani dashi azaman matsakaici na Crizotinib (CAS: 877399-52-5).
Crizotinib tabbas maganin ciwon daji ne ya zama alk (anaplastic lymphoma kinase) da kuma ros1 (c-ros oncogene 1) inhibitor, wanda aka amince da shi don maganin wasu cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan da ba na ƙananan ƙwayoyin cuta (NSCLC) a cikin Amurka da wasu ƙasashe, kuma jurewa da yawa karatu gwada aminci da inganci a anaplastic babban cell lymphoma, neuroblastoma, da sauran ci-gaba m ciwace-ciwacen daji a manya da yara.
Crizotinib magani ne da aka yi niyya don cutar kansar huhu mara ƙarami wanda Pfizer, Amurka ta haɓaka, secorri yanki ne da kuma maganin zamani a fagen maganin cutar kansar huhu.An amince da ita don tallace-tallace a Amurka a watan Agusta 2011 kuma an rubuta shi cikin jagororin kula da cutar daji na huhu na duniya a ƙarshen shekara a matsayin magani na farko ga marasa lafiya na ALK.An yarda da shi tare da Crizotinib shine hanyar farko ta ganewar asali ta hanyar amfani da fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, wannan ita ce hanyar da ake amfani da ita a halin yanzu a cikin gwaje-gwaje na asibiti na duniya don gano EML4-ALK fusion genes a cikin NSCLC.Wannan gwajin zai taimaka gano marasa lafiya waɗanda zasu iya amfana daga maganin Crizotinib.
Crizotinib wani zaɓi ne mai hana mai karɓar mai karɓa na tyrosine kinase wanda aka yi amfani dashi a cikin jiyya na zaɓaɓɓun lokuta na ci-gaban ciwon huhu da ba ƙananan ƙwayoyin cuta ba.Yana da dual ATP m inhibitor na tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) da ALK (cellular IC50 = 20 nM), dukansu biyu suna da muhimmiyar manufa don ciwon daji chemotherapy.Lokacin da aka gwada Crizotinib don zaɓi da sauran kinases an gano cewa yana da enzyme IC50's a cikin 100-ninka na c-MET don 13 na 120 kinases da aka gwada.A cikin gwaje-gwajen wayar hannu, an gano Crizotinib don hana RON (mai karɓar ra'ayin nantais) kinase tare da taga zaɓi mai ninki 10 akan c-MET.Gabaɗaya, wannan wakili yana hana haɓakar ƙwayar ƙwayar cuta.XALKORI®(Crizotinib) magani ne da ake amfani da shi don magance masu fama da ciwon huhu marasa kanana (NSCLC) wanda ya yadu zuwa wasu sassan jiki kuma yana haifar da lahani a cikin ko dai kwayoyin halittar da ake kira ALK (anaplastic lymphoma kinase) ko kwayoyin halitta mai suna ROS1.Ba a sani ba ko XALKORI yana da lafiya kuma yana da tasiri ga yara.
