1-Boc-4- (4-Bromopyrazol-1-yl) Piperidine CAS 877399-50-3 Tsafta ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na 1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) tare da babban inganci, matsakaici na Crizotinib (CAS: 877399- 52-5).Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Matsakaici na Crizotinib,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | 1-Boc-4- (4-Bromopyrazol-1-yl) Piperidine |
| Makamantu | Crizotinib-D;tert-Butyl 4- (4-Bromopyrazol-1-yl) piperidine-1-Carboxylate;4- (4-Bromopyrazol-1-yl) piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4- (4-Bromopyrazol-1-yl) piperidine;1- (4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4- (4-Bromo-1-Pyrazolyl) Piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl) -1H-Pyrazole;tert-butyl 4- (4-Bromo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;1- (4-Boc-1-Piperidinyl) -4-Bromopyrazole;Crizotinib rashin tsarki 4 |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 877399-50-3 |
| Tsarin kwayoyin halitta | Saukewa: C13H20BrN3O2 |
| Nauyin Kwayoyin Halitta | 330.23 g/mol |
| Matsayin narkewa | 77.0 zuwa 81.0 ℃ |
| Yawan yawa | 1.43 |
| Solubility | Mai narkewa a cikin methanol |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Kashi | Matsakaicin Crizotinib (CAS: 877399-52-5) |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Farin Tauri | Farin Tauri |
| Matsayin narkewa | 77.0 zuwa 81.0 ℃ | Ya bi |
| Ruwa ta Karl Fischer | <0.50% | 0.11% |
| Tsarkake / Hanyar Bincike | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Yayi daidai da Tsarin | Ya bi |
| Mass | Yayi daidai da Tsarin | Ya bi |
| Kammalawa | An gwada samfurin kuma ya bi ƙayyadaddun da aka bayar | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Tsarin al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
Alamomin haɗari Xn - Cuta
Lambobin haɗari 22 - Yana cutarwa idan an haɗiye
1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) ana amfani dashi azaman matsakaici na Crizotinib (CAS: 877399-52-5).Crizotinib (sunan ciniki Xalkori,) magani ne na rigakafin ciwon daji wanda ke aiki azaman ALK (anaplastic lymphoma kinase) da ROS1 (c-ros oncogene 1) inhibitor, wanda aka amince da shi don maganin wasu cututtukan huhu marasa ƙananan ƙwayoyin cuta (NSCLC) a cikin Amurka. da wasu wasu ƙasashe, kuma ana fuskantar gwaji na asibiti suna gwada lafiyarta da ingancinta inanaplastic manyan ƙwayoyin lymphoma, neuroblastoma, da sauran ciwace-ciwacen ciwace-ciwace a cikin manya da yara.
A watan Agustan 2011, FDA ta Amurka ta amince da Crizotinib (PF-02341066) don maganin anaplastic lymphoma kinase (ALK) wanda ya sake tsara ciwon huhu na huhu (NSCLC).Crizotinib ne mai dual ATP m inhibitor na tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) da ALK (cellular IC50 = 20 nM), dukansu biyu suna da muhimmiyar manufa don ciwon daji chemotherapy.Lokacin da aka gwada Crizotinib don zaɓi da sauran kinases an gano cewa yana da enzyme IC50's a cikin 100-ninka na c-MET don 13 na 120 kinases da aka gwada.A cikin gwaje-gwajen wayar hannu, an gano Crizotinib don hana RON (mai karɓar ra'ayin nantais) kinase tare da taga zaɓi mai ninki 10 akan c-MET.
