1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole CAS 877399-73-0 Tsarkake ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) tare da babban inganci, matsakaici na Crizotinib (CAS: 877399-52) -5).Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Matsakaici na Crizotinib,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Makamantu | 1-Boc-4- (4-Iodo-1H-Pyrazol-1-yl) piperidine;tert-Butyl 4- (4-Iodo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;tert-Butyl 4- (4-Iodopyrazolyl) piperidinecarboxylate;Crizotinib rashin tsarki 16 |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 877399-73-0 |
| Tsarin kwayoyin halitta | Saukewa: C13H20IN3O2 |
| Nauyin Kwayoyin Halitta | 377.22 g/mol |
| Matsayin narkewa | 97 ℃ |
| Yawan yawa | 1.60± 0.10 g/cm3 |
| M | Hasken Hannu |
| Adana Yanayin. | 2 ~ 8 ℃, Kare Daga Haske |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Kashi | Matsakaicin Crizotinib (CAS: 877399-52-5) |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Fari zuwa Hasken Rawaya Mai ƙarfi | Farin Tauri |
| Tsarkake / Hanyar Bincike | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Yayi daidai da Tsarin | Ya bi |
| 1 H NMR Spectrum | Yayi daidai da Tsarin | Ya bi |
| ESI+ | Ya dace | Ya bi |
| Kammalawa | An gwada samfurin kuma ya bi ƙayyadaddun da aka bayar | |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Tsarin al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) tare da babban inganci, matsakaici na Crizotinib (CAS: 877399-52-5).Crizotinib magani ne da aka yi niyya don cutar kansar huhu mara ƙarami wanda Pfizer, Amurka ta haɓaka, secorri yanki ne da kuma maganin zamani a fagen maganin cutar kansar huhu.An amince da ita don tallace-tallace a Amurka a watan Agusta 2011 kuma an rubuta shi cikin jagororin kula da cutar daji na huhu na duniya a ƙarshen shekara a matsayin magani na farko ga marasa lafiya na ALK.An yarda da shi tare da Crizotinib shine hanyar farko ta ganewar asali ta hanyar amfani da fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, wannan ita ce hanyar da ake amfani da ita a halin yanzu a cikin gwaje-gwaje na asibiti na duniya don gano EML4-ALK fusion genes a cikin NSCLC.Wannan gwajin zai taimaka gano marasa lafiya waɗanda zasu iya amfana daga maganin Crizotinib.a kan 25, wannan shine magani na farko da za a yi amfani da shi a cikin maganin marasa lafiya tare da ciwon daji na gida ko ƙananan ƙananan ƙwayoyin cuta (NSCLC) wanda shine anaplastic lymphoma kinase (ALK) - tabbatacce kamar yadda aka ƙaddara ta hanyar SFDA-approved assay.
Crizotinib (PF-02341066) Crizotinib shine mai karfin c-Met da ALK inhibitor, ƙimar IC50 a cikin gwajin tantanin halitta sune 11 nM da 24 nM, bi da bi.Hakanan shine mai hanawa mai ƙarfi na ROS1 tare da ƙimar Ki ƙasa da 0.025 nM.Crizotinib na iya haifar da autophagy a cikin nau'o'in kwayoyin cutar kansa ta huhu ta hanyar hana hanyar STAT3.
