CAS 945667-22-1 Tsaftace> 99.0% (HPLC) API Featured Hoton

CAS 945667-22-1 Tsarkake>99.0% (HPLC) API

Takaitaccen Bayani:

Saukewa: 945667-22-1

Tsafta:> 99.0% (HPLC)

Bayyanar: Farin Foda

API, Babban inganci, Samar da Kasuwanci

E-Mail: alvin@ruifuchem.com

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Cikakken Bayani

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Bayani:

Ruifu Chemical Supply Intermediates
Saukewa: CAS361442-04-8
Saukewa: CAS945667-22-1
(R) -1-Boc-3-Aminopperidine CAS 188111-79-7
(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2- (3-Hydroxy-1-Adamantyl) -2-Oxoacetic Acid CAS 709031-28-7

Abubuwan Sinadarai:

Makamantu	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ] hexane-3-Carbonitrile Hydrate
Lambar CAS	945667-22-1
Lambar CAT	RF-PI1992
Matsayin Hannun jari	A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton
Tsarin kwayoyin halitta	C18H25N3O2·H2O
Nauyin Kwayoyin Halitta	333.43
Alamar	Ruifu Chemical

Ƙayyadaddun bayanai:

Abu	Ƙayyadaddun bayanai
Bayyanar	Farin Foda
ganewa	A: IR B: Lokacin Riƙewar HPLC
Tsarkake / Hanyar Bincike	> 99.0% (HPLC, Kan Busassun Tushen)
Abubuwan Ruwa (KF)	5.3% ~ 7.3%
Ragowa akan Ignition	<0.20%
Tsaftace Guda Daya	<0.50%
Jimlar ƙazanta	<1.00%
Karfe masu nauyi	<10ppm
Arsenic (AS)	<2pm
Microbiology
Jimlar Ƙididdigar Faranti	<1000cfu/g
Yisti & Mold	<100cfu/g
E. Coli	Korau
S. Aure	Korau
Salmonella	Korau
Rayuwar Rayuwa	Watanni 24
Matsayin Gwaji	Matsayin Kasuwanci
Amfani	API;Ana amfani da shi don Maganin Ciwon Ciwon Na II

Kunshin & Ajiya:

Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata

Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi

Amfani:

FAQ:

Aikace-aikace:

API (CAS: 945667-22-1) zaɓi ne kuma mai hana dipeptidyl peptidase-4 (DPP4) mai hanawa wanda za'a iya amfani dashi don haɓaka jiyya don nau'in ciwon sukari na 2.Yana da zaɓaɓɓen kuma mai jujjuyawar DPP4 mai hanawa tare da IC50 na 26 nM da Ki na 1.3 nM.IC50 darajar: 26 nM.Manufa: DPP4 a cikin vitro: Yana da hanawa akai-akai Ki na 1.3 nM don hanawa DPP4, wanda ya ninka sau 10 fiye da Sitagliptin (wasu masu hana DPP4 guda biyu) tare da Ki na 13 da 18 nM.Bugu da ƙari, Yana nuna ƙayyadaddun ƙayyadaddun bayanai don DPP4 fiye da ko dai DPP8 ko DPP9 enzymes (400- da 75- ninka, bi da bi).Metablite mai aiki da shi ba shi da ƙarfi sau biyu fiye da iyaye.Dukansu (CAS: 945667-22-1) da metabolite ɗin sa suna da zaɓi sosai (> 4000-ninka) don rigakafin DPP4 idan aka kwatanta da kewayon sauran ƙwayoyin cuta.(CAS: 945667-22-1) yana rage lalacewar incretin hormone glucagon-kamar peptide-1, don haka inganta ayyukansa, kuma yana da alaƙa da ingantaccen aikin β-cell da kuma kawar da ɓoyewar glucagon.in vivo: Yana da matukar tasiri. a fitar da ingantattun kayan haɓaka masu dogaro da kashi a cikin sharewar glucose a cikin kewayon kashi 0.13-1.3 mg/kg a cikin ƙwayoyin ob/ob dangane da sarrafawa.