Celecoxib CAS 169590-42-5 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na Celecoxib (CAS: 169590-42-5) tare da babban inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Celecoxib,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | Celecoxib |
| Makamantu | Celebrex;Biki;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4-[5- (4-Methylphenyl) -3- (Trifluoromethyl) -1H-Pyrazol-1-yl] benzenesulfonamide;5- (4-Methylphenyl) -1- (4-Sulfamoylphenyl) -3- (Trifluoromethyl) pyrazole |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 169590-42-5 |
| Tsarin kwayoyin halitta | Saukewa: C17H14F3N3O2S |
| Nauyin Kwayoyin Halitta | 381.37 g/mol |
| Matsayin narkewa | 160.0 zuwa 165.0 ℃ |
| Yawan yawa | 1.43± 0.10 g/cm3 |
| Ruwan Solubility | Mara narkewa a cikin Ruwa |
| Solubility | Soluble sosai a cikin methanol;Mai narkewa a cikin Ethanol |
| COA & MSDS | Akwai |
| Misali | Akwai |
| Asalin | Shanghai, China |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Fari ko Kusan Farin Crystalline Foda | Ya bi |
| Assay | 98.0 ~ 102.0% | 99.8% |
| Matsayin narkewa | 160.0 zuwa 165.0 ℃ | 162.2 ℃ |
| Ruwa ta Karl Fischer | <0.50% | 0.11% |
| Ragowa akan Ignition | <0.20% | 0.05% |
| Karfe masu nauyi (Pb) | ≤20ppm | <10ppm |
| Abubuwan da ke da alaƙa da Celecoxib A | <0.40% | <0.20% |
| Abubuwan da ke da alaƙa da Celecoxib B | <0.10% | <0.10% |
| Rashin Tsabtace Mutum Daya | <0.10% | <0.10% |
| Jimlar ƙazanta | <0.50% | 0.20% |
| Infrared Spectrum | Daidai da Tsarin | Ya bi |
| 1H NMR Spectrum | Daidai da Tsarin | Ya bi |
| Kammalawa | An gwada samfurin kuma ya dace da ƙayyadaddun da aka bayar | |
Kunshin:Fluorinated Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Celecoxib
Bayani na C17H14F3N3O2S 381.4
4-[5- (4-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide;
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide [169590-42-5]
BAYANI
Celecoxib ya ƙunshi NLT 98.0% da NMT 102.0% na C17H14F3N3O2S, ƙididdiga akan tushen anhydrous
GANO
• A. INFRARED ABSORPTION <197>: [Hanyoyin NOTE <197A>, <197K>, ko <197M> a ƙarƙashin shayarwar Infrared ana iya amfani dashi.]
[NOTE-Idan bakan da aka samu ya nuna bambance-bambance, narkar da abun da za a bincika da kuma Ma'aunin Magana daban a cikin barasa na isopropyl, ƙafe zuwa bushewa, da rikodin sabon bakan.]
• B. Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na daidaitaccen bayani, kamar yadda aka samu a cikin Assay.
ASSAY
• TSARI
Buffer: 2.7 g/L na monobasic potassium phosphate gyara tare da phosphoric acid zuwa pH na 3.0 ± 0.2
Lokacin wayar hannu: methanol, acetonitrile, da buffer (3:1:6)
Diluent: methanol da ruwa (3: 1)
Maganin dacewa da tsarin: 0.5 mg/ml na USP
Celecoxib RS da 2.4 µg/mL kowanne na USP Celecoxib Abubuwan da ke da alaƙa da haɗin gwiwar A RS da USP Celecoxib mai alaƙa da haɗin gwiwa B RS a cikin Diluent
Daidaitaccen bayani: 0.5 mg/mL na USP Celecoxib RS a cikin Diluent
Maganin samfurin: 0.5 mg/mL na Celecoxib a cikin Diluent
Tsarin chromatographic
(Duba Chromatography <621>, Dacewar Tsarin.)
Yanayin: LC
Mai ganowa: UV 215 nm
Tushen: 4.6-mm × 25-cm;5-µm shiryarwa L11
Yanayin zafin jiki: 60°
Yawan gudu: 1.5 ml/min
Girman allura: 25µL
Lokacin gudu: Kusan sau 1.5 na celecoxib kololuwar elution
Dacewar tsarin
Samfurori: Maganin dacewa da tsarin da daidaitaccen bayani
Abubuwan da suka dace
Resolution: NLT 1.8 tsakanin celecoxib alaka fili A da Celecoxib da NLT 1.8 tsakanin Celecoxib da Celecoxib da alaka fili B, Tsarin dacewa bayani
Matsakaicin daidaitaccen dangi: NMT 0.73%, Daidaitaccen bayani
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi lissafin adadin C17H14F3N3O2S a cikin ɓangaren Celecoxib da aka ɗauka:
Sakamako = (rU/rS) × (CS/CU) × 100
rU = kololuwar amsa daga Maganin Samfurin
rS = kololuwar amsa daga daidaitaccen bayani
CS = maida hankali na daidaitaccen bayani (mg/ml)
CU = maida hankali na Maganin Samfurin (mg/mL)
Sharuɗɗan karɓa: 98.0% ~ 102.0% akan tushen anhydrous
RASHIN ZUCIYA
Najasa Na Inorganic
• KARFE MAI KYAU: NMT 20 ppm
Diluent: Acetone da ruwa (17: 3)
Daidaitaccen Magani: Tsarma 1.0 ml na Madaidaicin Maganin Gubar, wanda aka shirya kamar yadda aka umurce shi a ƙarƙashin Ƙarfe Masu nauyi <231>, Reagents na Musamman, tare da Diluent zuwa 20 ml.
Maganin samfurin: Narke 0.50 g na Celecoxib a cikin 20ml na Diluent.
Maganin Blank: 20 ml na Diluent
Bincike
Samfura: Daidaitaccen Magani, Maganin Blank, da Samfurin Magani
A kowace bayani, ƙara 2 ml na PH 3.5 Acetate mai buffer wanda aka shirya a ƙarƙashin umarnin 1.2 ml na TS na GlycheTamide-glycerin Tri.Mix nan da nan, kuma ba da izinin tsayawa na 2 min.Wuce mafita ta hanyar tace girman pore 0.45-µm.Kwatanta tabo akan matatun da aka samu daga kowane mafita.
Sharuɗɗan karɓa: Launin launin ruwan kasa-baƙar fata na tabo da ke fitowa daga Maganin Samfurin bai fi na tabo da aka samu daga daidaitaccen bayani ba.Jarabawar ba ta da inganci idan daidaitaccen bayani bai nuna launin ruwan kasa-baki ba idan aka kwatanta da Maganin Blank.
• SAURAN WUTA <281>: NMT 0.2%, ta amfani da crucible platinum
Najasa Na Halitta
• PROCEDUR
Buffer, Wayar hannu, Diluent, Maganin dacewa da tsarin, Samfurin Magani, da Tsarin Chromatographic: Ci gaba kamar yadda aka umurce a cikin Assay.
Daidaitaccen bayani: 0.5 µg/ml na USP Celecoxib RS a cikin Diluent
Dacewar tsarin
Samfurori: Maganin dacewa da tsarin da daidaitaccen bayani
Abubuwan da suka dace
Resolution: NLT 1.8 tsakanin Celecoxib alaka fili A da Celecoxib da NLT 1.8 tsakanin Celecoxib da Celecoxib da alaka fili B, Tsarin dacewa bayani
Matsakaicin siginar-zuwa-amo: NLT 20, Daidaitaccen bayani
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi ƙididdige adadin kowane ƙazanta a cikin ɓangaren Celecoxib da aka ɗauka:
Sakamako = (rU/rS) × (CS/CU) × 100
rU = kololuwar amsa ga kowane kazanta a cikin Samfurin bayani
rS = kololuwar martani na celecoxib a cikin daidaitaccen bayani
CS = taro na celecoxib a cikin daidaitaccen bayani (mg/mL)
CU = maida hankali na Celecoxib a cikin Samfurin bayani (mg/mL)
Sharuɗɗan karɓa
Najasa ɗaya: Duba Table 1.
[NOTE-Yi watsi da kowane kololuwar ƙazanta da ke ƙasa da 0.05%.]
Tebur 1
| Suna | Lokacin Tsayawa Dangi | Sharuɗɗan karɓa NMT (%) |
| Celecoxib alaka mahadi Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Abubuwan da ke da alaƙa da Celecoxib Bb | 1.1 | 0.10 |
| Rashin ƙazanta ɗaya wanda ba a bayyana ba | - | 0.10 |
| Jimlar ƙazanta | - | 0.5 |
a 4-[5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
b 4-[3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
MAKAMMAN JARRABAWA
• Ƙaddamar da ruwa, Hanyar I <921>: NMT 0.5%, ta amfani da samfurin 400-mg
KARIN BUKATA
• KYAUTA DA ARJIYA: Ajiye a cikin matsuguni, an kiyaye shi daga haske da danshi.Ajiye a zafin jiki
• MATSAYIN MAGANAR USP <11>
USP Celecoxib RS
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide
Bayani na C17H14F3N3O2S 381.4
Abubuwan da ke da alaƙa da USP Celecoxib A RS
4-[5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
Bayani na C17H14F3N3O2S 381.4
Abubuwan da ke da alaƙa da USP Celecoxib B RS
4-[3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
Bayani na C17H14F3N3O2S 381.4
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
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Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
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| Alamomin haɗari | Xn - Mai cutarwa |
| Lambobin haɗari | R20/21/22 - Cutarwa ta hanyar shakarwa, a cikin hulɗa da fata kuma idan an haɗiye shi. |
| R52 - Mai cutarwa ga halittun ruwa | |
| R61 - Yana iya haifar da lahani ga yaron da ba a haifa ba | |
| R60 - Zai iya lalata haihuwa | |
| Bayanin Tsaro | S22 - Kar a shaka kura. |
| S24/25 - Guji hulɗa da fata da idanu. | |
| S28 - Bayan haɗuwa da fata, wanke nan da nan da sabulu-suds mai yawa. | |
| S37/39 - Saka safofin hannu masu dacewa da kariya / ido | |
| ID na UN | UN 3077 9 / PGIII |
| WGK Jamus | 3 |
| RTECS | Saukewa: DB2944937 |
| HS Code | 2935900090 |
| Matsayin Hazard | HAUSHI |
Celecoxib da Rofecoxib biyu ne masu hana COX-2 da ake amfani da su a halin yanzu.Nasarar haɓaka ta GD Searle & Pfizer Co. (US,) wanda aka saki a cikin 1999, sunan kasuwanci: Celebrex.Celecoxib wakili ne wanda ba na steroidal ba, mai hana kumburi tare da tasirin analgesic da anti-mai kumburi, yana haifar da mafi ƙanƙanta abin da ya faru na ƙwanƙwasa gastrointestinal na sama da sauran rikitarwa.An yi amfani da shi a asibiti don magance cututtuka na osteoarthritis mai tsanani da na kullum da rheumatoid amosanin gabbai, tare da aikin analgesic anti-mai kumburi, kawar da alamu da alamun osteoarthritis da rheumatoid arthritis.
Celecoxib (CAS: 169590-42-5), Domin taimako da kuma kula da osteoarthritis (OA), rheumatoid amosanin gabbai (RA), yara rheumatoid amosanin gabbai (JRA), ankylosing spondylitis, m zafi, na farko dysmenorrhea da baki adjunct zuwa saba kula da marasa lafiya. tare da adenomatous polyposis na iyali.
Celecoxib (CAS: 169590-42-5) yana da tasirin anti-mai kumburi da analgesic na NSAIDs.Saboda tsarin sinadarai, ana iya haɗa shi tare da COX-2, da zaɓin hana COX-2.Ƙungiyar phenyl ta ɗaure tare da tashar hydrophobic na COX-2, kuma hydrophilic sulfonamide ya samar da sarkar hydrogen tare da 513 arginine da 90 histidine a cikin COX-2 "aljihun gefe."Hakanan yana cikin kusanci da arginine a cikin matsayi na COX-2120 kuma yana taka rawa wajen hana COX-2 daga canza arachidonic acid zuwa prostaglandins waɗanda ke cutar da jikin ɗan adam. -2, Celecoxib ba zai iya shiga cikin kwayoyin COX-1 ba, kuma ba zai hana shi canzawa na arachidonic acid zuwa prostaglandins ba, don haka, yana da sakamako mai kyau na anti-mai kumburi da analgesic, yana kare mucosa na ciki, yana kare yaduwar jini na koda, yana daidaita jigilar platelet, kuma yana warware matsalar. Matsalolin haushin ciki na NSAIDs da aka saba amfani da su.
Ana nuna Celecoxib (CAS: 169590-42-5) don maganin osteoarthritis da rheumatoid arthritis.An haramta amfani da shi a cikin mutanen da ke da hypersensitivity zuwa sulfonamides ko wasu NSAIDs.Ya kamata a yi amfani da shi a hankali a cikin mutanen da ke fama da ciwon hanta.Ma'amala yana faruwa tare da wasu magunguna waɗanda ke haifar da CYP2C9 (misali rifampin rifampin) ko gasa don haɓaka metabolism ta wannan enzyme (misali fluconazole, leflunomide).Mafi yawan halayen rashin lafiya ga celecoxib suna da sauƙi zuwa matsakaicin tasirin GI kamar dyspepsia, gudawa, da ciwon ciki.Mummunan GI da tasirin koda sun faru da wuya.
