Chloramphenicol CAS 56-75-7 Tsafta ≥99.0% (HPLC) Babban Tsabta
Samar da Mai ƙirƙira tare da Babban Tsafta da Samar da Kasuwanci
(1R,2R)-(-)-2-Amino-1- (4-nitrophenyl) -1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1- (4-nitrophenyl) -1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
Sunan Sinadari | Chloramphenicol |
Makamantu | D (-) threo-2-Dichloroacetamido-1- (4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1- (4-nitrophenyl) -2-propyl] acetamide |
Lambar CAS | 56-75-7 |
Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
Tsarin kwayoyin halitta | Saukewa: C11H12Cl2N2O5 |
Nauyin Kwayoyin Halitta | 323.13 |
Matsayin narkewa | 149.0 zuwa 153.0 ℃ (lit.) |
M | Hasken Hannu |
Solubility | Soluble sosai a cikin Ethanol, Methanol, Acetone.Mai narkewa a cikin Ether, Chloroform.Ba a iya narkewa a cikin Benzene.A zahiri Mara narkewa a cikin Ruwa |
Yanayin jigilar kaya | An aika Karkashin Zazzabin yanayi |
COA & MSDS | Akwai |
Asalin | Shanghai, China |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari zuwa Hasken Fada mai Rawaya |
Identification A | Infrared Absorption |
Identity B | Lokacin riƙewa na babban kololuwa a cikin chromatogram na shirye-shiryen Assay ya dace da abin da ke cikin chromatogram na daidaitaccen shiri, kamar yadda aka samu a cikin Assay. |
Takamaiman Juyawar gani | +17.0°~+20.0° |
Matsayin narkewa | 149.0 ~ 153.0 ℃ |
Crystallinity | Ya Cika Abubuwan Bukatu |
pH | 4.5 ~ 7.5 |
Rashin Tsabtace Guda Daya | ≤0.50% |
Jimlar ƙazanta | ≤1.00% |
Karfe masu nauyi | ≤20ppm |
Arsenic | ≤1pm |
Asara akan bushewa | ≤0.50% (105 ℃, 3 hours) |
Ragowa akan Ignition | ≤0.10% |
Tsarkake / Hanyar Bincike | ≥99.0% (HPLC) |
Matsayin Gwaji | Matsayin Kasuwanci;JP ;USP |
Kunshin: kwalban, Aluminum tsare jakar, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol ya ƙunshi bai wuce kashi 97.0 ba kuma bai wuce kashi 103.0 na C11H12Cl2N2O5 ba.
Marufi da ajiya-Ajiye a cikin matsuguni.
Lakabi-Inda aka yi niyya don amfani da shi wajen shirya nau'ikan allura ko wasu nau'ikan alluran bakararre, alamar ta bayyana cewa ba ta da lafiya ko kuma dole ne a ƙara sarrafa ta yayin shirye-shiryen alluran allura ko wasu nau'ikan alluran bakararre.
Matsayin Magana na USP <11>-
USP Chloramphenicol RS Danna don Duba Tsarin
USP Endotoxin RS
Ganewa-
A: Ciwon Infrared <197K>.
B: Lokacin riƙewa na babban kololuwa a cikin chromatogram na shirye-shiryen Assay ya dace da abin da ke cikin chromatogram na daidaitaccen shiri, kamar yadda aka samu a cikin Assay.
Kewar narkewa <741>: tsakanin 149 da 153.
Takamaiman juyawa <781S>: tsakanin +17.0 da +20.0.
Maganin gwaji: 50 MG, ba a bushe ba, kowace ml, a cikin barasa mai bushewa.
Crystallinity <695>: ya dace da buƙatun.
Bacterial endotoxins 85-Inda aka yi nufin amfani da Chloramphenicol don shirya nau'ikan alluran allura, yana ƙunshe da bai wuce 0.2 USP Endotoxin Unit da MG na chloramphenicol ba.
Haihuwa 71- Inda alamar ta bayyana cewa Chloramphenicol ba ta da lafiya, ta cika buƙatun lokacin da aka gwada ta kamar yadda aka umurce ta don Tacewar Membrane a ƙarƙashin Gwajin Haihuwar Samfur don a gwada, sai dai don amfani da 1 g na ƙaƙƙarfan samfur.
pH <791>: tsakanin 4.5 da 7.5, a cikin dakatarwar ruwa mai ɗauke da 25 MG kowace ml.
Tsaftar Chromatographic-Narkar da adadin Chloramphenicol daidai gwargwado a cikin methanol don samun maganin gwaji mai ɗauke da MG 10 a kowace ml.Shirya maganin USP Chloramphenicol RS a cikin methanol mai dauke da 10 MG kowace ml (Standard bayani A).Tsarma sassan daidaitaccen bayani A ƙididdigewa tare da methanol don samun daidaitaccen maganin B mai ɗauke da 100 µg kowace ml da daidaitaccen bayani C mai ɗauke da 50 µg kowace ml.Aiwatar da ɓangarorin 20-µL na maganin gwajin da daidaitattun mafita B da C zuwa farantin chromatographic na bakin ciki mai dacewa (duba Chromatography 621), mai rufi da 0.25-mm Layer na chromatographic silica gel cakuda.Ƙirƙirar chromatogram a cikin tsarin narkewa wanda ya ƙunshi cakuda chloroform, methanol, da glacial acetic acid (79:14:7) har sai da gaban sauran ƙarfi ya motsa kusan kashi uku cikin huɗu na tsawon farantin.Cire farantin daga ɗakin, bushe-bushe, kuma bincika ƙarƙashin hasken UV mai ɗan gajeren zango: duk wani tabo ban da babban tabo da aka samu daga maganin gwajin bai wuce girman ko ƙarfin babban wurin da aka samu daga daidaitaccen bayani na B (1% ), da jimlar ƙazantattun abubuwan da aka wakilta ta duk wuraren ban da babban tabo, dangane da kwatanta ƙarfin irin waɗannan wuraren tare da ƙarfin manyan wuraren da aka samu daga Standard Solution B da C, bai wuce 2% ba. .
Assay-
Wayar hannu lokaci-Shirya dace tace cakuda ruwa, methanol, da glacial acetic acid (55:45:0.1).Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography 621).
Daidaitaccen shiri- Narkar da adadin USP Chloramphenicol RS daidai gwargwado a cikin lokacin Wayar hannu, kuma a tsarma ƙididdigewa, da mataki-mataki idan ya cancanta, tare da lokacin Wayar hannu don samun mafita yana da sananniya na kusan 80 µg kowace ml.Tace wani yanki na wannan maganin ta hanyar tacewa na 0.5-µm ko mafi kyawun porosity filter, kuma amfani da tsararren tacewa azaman daidaitaccen shiri.
Shirye-shiryen Assay- Canja wurin kusan 200 MG na Chloramphenicol, daidai a auna, zuwa faifan volumetric 100-mL, ƙara lokacin Wayar hannu zuwa ƙara, da haɗuwa.Canja wurin 4.0 ml na maganin da aka samu zuwa 100-mL flask volumetric, tsarma tare da Wayar hannu zuwa girma, da haɗuwa.Tace wani yanki na wannan maganin ta hanyar tacewa na 0.5-µm ko mafi kyawun porosity, kuma yi amfani da tsararren tacewa azaman shirin Assay.
Tsarin Chromatographic (duba Chromatography <621>) -Chromatograph na ruwa yana sanye da na'urar ganowa 280-nm da ginshiƙin 4.6-mm × 10-cm wanda ya ƙunshi 5-µm tattara L1.Matsakaicin kwarara shine kusan 1 ml a minti daya.Chromatograph the Standard shiri, da rikodin kololuwar martani kamar yadda aka umurce a ƙarƙashin Tsari: ingancin ginshiƙi da aka ƙaddara daga kololuwar nazari bai wuce faranti na ka'idar 1800 ba, ma'aunin wutsiya bai wuce 2.0 ba, kuma madaidaicin madaidaicin ƙa'idar don kwafin allurar ba ta kasance ba. fiye da 1.0%.
Tsari-[bayanin kula-Yi amfani da tsayin tsayi inda aka nuna kololuwar martani.] dabam dabam (kimanin 10 µL) na daidaitaccen shiri da shirye-shiryen Assay a cikin chromatograph, yi rikodin chromatograms, da auna martani ga manyan kololuwa.Yi ƙididdige adadin, a cikin MG, na C11H12Cl2N2O5 a cikin ɓangaren Chloramphenicol da aka ɗauka ta dabara:
2.5C (rU / rS)
a cikin abin da C shine maida hankali, a cikin µg a kowace ml, na USP Chloramphenicol RS a cikin Shirye-shiryen Daidaitawa, kuma rU da rS sune mafi girman martanin da aka samu daga shirye-shiryen Assay da kuma daidaitaccen shiri, bi da bi.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1- (4-nitrophenyl) propan-2-yl] acetamide [56-75-7]
Chloramphenicol ya ƙunshi ba kasa da 980 MG (ikon) kuma bai wuce 1020 MG (ikon) da MG ba, lasafta akan busassun tushe.An bayyana ƙarfin Chloramphenicol azaman taro (ƙarfin) na chloramphenicol (C11H12Cl2N2O5).
Bayanin Chloramphenicol yana faruwa azaman fari zuwa fari mai rawaya, lu'ulu'u ko foda.
Yana narkewa da yardar kaina a cikin methanol kuma a cikin ethanol (99.5), kuma yana ɗan narkewa cikin ruwa.
Identification (1) Ƙayyade nau'in nau'in samfurin samfurin da aka samo a cikin Assay kamar yadda aka umarce shi a ƙarƙashin Ultraviolet-visible Spectrophotometry <2.24>, kuma kwatanta bakan tare da Bakan Magana ko bakan bayani na Chloramphenicol RS da aka shirya a cikin hanya ɗaya kamar yadda yake. Maganin samfurin: duka sifofi biyu suna nuna irin ƙarfin sha a tsayi iri ɗaya.
(2) Ƙayyade nau'in shayarwar infrared na Chloramphenicol kamar yadda aka umarce shi a cikin hanyar faifan potassium bromide a ƙarƙashin Infrared Spectrophotometry <2.25>, kuma kwatanta bakan tare da Spectrum Reference ko bakan na Chloramphenicol RS: duka bakan suna nuna irin ƙarfin sha a iri ɗaya. lambobin igiyar ruwa.
Juyawar gani <2.49> [a] 20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 ml, 100 mm.
Matsayin narkewa <2.60> 150 ~ 155 ℃
Tsarkake (1) Karfe masu nauyi <1.07>- Ci gaba da 1.0 g na Chloramphenicol bisa ga Hanyar 2, kuma yi gwajin.Shirya maganin sarrafawa tare da 2.5 ml na Maganin Jagorar Jagora (ba fiye da 25 ppm ba).
(2) Arsenic <1.11> -Shirya maganin gwajin tare da 2.0 g na Chloramphenicol bisa ga Hanyar 4, kuma yi gwajin (ba fiye da 1 ppm ba).
(3) Abubuwan da ke da alaƙa-Narke 0.10 g na Chloramphenicol a cikin 10 ml na methanol, kuma amfani da wannan maganin azaman maganin samfurin.Pipet 1 ml na maganin samfurin, ƙara methanol don yin daidai 100 ml, kuma amfani da wannan bayani azaman daidaitaccen bayani (1).Pipet 10 ml na daidaitaccen bayani (1), ƙara methanol don yin daidai 20 ml, kuma amfani da wannan maganin azaman daidaitaccen bayani (2).Yi gwajin tare da waɗannan mafita kamar yadda aka umurce su ƙarƙashin Thin-Layer Chromatography <2.03>.Spot 20 ml kowane samfurin bayani da daidaitattun mafita (1) da (2) akan farantin silica gel tare da nuna alama mai kyalli don chromatography na bakin ciki, haɓaka farantin tare da cakuda chloroform, methanol da acetic acid (100) (100). 79:14:7) zuwa nisa na kusan 15 cm, kuma a bushe farantin iska.Bincika a ƙarƙashin hasken ultraviolet (babban tsayin raƙuman ruwa: 254 nm): tabo ban da babban tabo da tabo akan asalin da aka samu daga maganin samfurin ba su da ƙarfi fiye da tabo da aka samu daga daidaitaccen bayani (1), da jimlar amunt. daga cikin wadannan spots daga samfurin bayani bai wuce 2.0% ba.
Asarar bushewa <2.41> Ba fiye da 0.5% (1 g, 105 ℃, 3 hours).
Ragowa akan kunnawa <2.44> Bai wuce 0.1% ba (1 g).
Assay Auna daidai adadin Chloramphenicol da Chloramphenicol RS, daidai yake da kusan 0.1 g (ikon), narkar da kowanne a cikin 20 ml na methanol, sannan a ƙara ruwa don yin daidai 100 ml.Bututu 20 ml kowanne daga cikin wadannan mafita, kuma ƙara ruwa don yin daidai 100 ml.Pipet 10 ml kowane ɗayan waɗannan mafita, ƙara ruwa don yin daidai 100 ml, kuma amfani da waɗannan mafita azaman samfurin samfurin da daidaitaccen bayani.Ƙayyade abubuwan sha, AT da AS, a 278 nm na samfurin samfurin da daidaitaccen bayani kamar yadda aka umurce su a ƙarƙashin Ultraviolet-visible Spectrophotometry <2.24>.
Adadin [mg (ikon)] na chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Adadin [mg (ikon)] na Chloramphenicol RS
dauka
Kwantena da Akwatunan ajiya - Kwantena masu tsauri.
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Lambobin haɗari R45 - Yana iya haifar da ciwon daji
R11 - Mai ƙonewa sosai
R39/23/24/25 -
R23/24/25 - Mai guba ta hanyar inhalation, a cikin hulɗa da fata kuma idan an haɗiye shi.
Bayanin Tsaro S53 - Guji fallasa - sami umarni na musamman kafin amfani.
S45 - Idan akwai haɗari ko kuma idan kun ji rashin lafiya, nemi shawarar likita nan da nan (nuna alamar a duk lokacin da zai yiwu.)
S16 - Ka nisantar da tushen wuta.
S36/37 - Sanya tufafin kariya da safar hannu masu dacewa.
Bayanan Bayani na UN2811
WGK Jamus 3
Saukewa: AB6825000
FLUKA BRAND F CODES 3-10
TSCA da
Bayanan Bayani na HS2941400000
Hazard Darasi na 3
Guba LD50 na baka a cikin bera: 2500mg/kg
P501: Zuba abun ciki/kwantena zuwa wurin da aka amince da sharar sharar gida.
P260: Kada ku shaka ƙura / hayaki / gas / hazo / tururi / fesa.
P270: Kada ku ci, sha ko shan taba lokacin amfani da wannan samfurin.
P202: Kar a rike har sai an karanta kuma an fahimci duk matakan tsaro.
P201: Samu umarni na musamman kafin amfani.
P264: A wanke fata sosai bayan sarrafa.
P280: Saka safofin hannu masu kariya / tufafi masu kariya / kariya ta ido / kariya ta fuska.
P308 + P313: IDAN fallasa ko damuwa: Samu shawara / kulawar likita.
P405: Store a kulle.
Shanghai Ruifu Chemical Co., Ltd. shine babban mai samar da Chloramphenicol (CAS: 56-75-7) tare da inganci.Chloramphenicol wani nau'in maganin rigakafi ne mai fadi, wanda shine zabi na farko don maganin typhoid da paratyphoid, na biyu kuma, ana amfani da shi don maganin cututtuka daban-daban da ƙananan ƙwayoyin cuta ke haifar da su.Saboda mummunan halayen halayen yanzu ana amfani da ƙasa da ƙasa.Bakan maganin kashe kwayoyin cuta, aiki da amfani iri daya ne da chloramphenicol don maganin Salmonella Typhi, Shigella, Escherichia coli, mura, Brucella, cututtukan huhu da cocci da sauran magungunan kashe kwayoyin cuta ke haifarwa.An fi amfani da Chloramphenicol don magance cututtukan urinary, ciwon huhu, ciwon ciki da ciwon huhu da kwayoyin cuta ke haifarwa, da kuma digon ido na waje da digon kunne.
UN3249 Magani, m, mai guba, nos, Hazard Class: 6.1;Takaddun shaida: 6.1-Kayan guba.UN2811 Daskararru mai guba, kwayoyin halitta, nos, Class Hazard: 6.1;Takaddun shaida: 6.1- Abubuwan guba, Sunan Fasaha da ake buƙata.