Citric Acid Anhydrous CAS 77-92-9 Assay 99.5 ~ 100.5%

Citric acid [77-92-9].
BAYANI
Citric acid anhydrous yana ƙunshe da NLT 99.5% da NMT 100.5% na C6H8O7, ana ƙididdige su akan tushen anhydrous.
GANO
• Ciwon Infrared <197K>: bushe abin da za a bincika a 105 ℃ na 2 h.
ASSAY
• Tsari
Misali: 0.550 g na Citric Acid Anhydrous;rikodin nauyi daidai.
Analysis: Narke Samfurin a cikin 50 ml na ruwa.Ƙara 0.5 ml na phenolphthalein TS.Titrate tare da 1 N sodium hydroxide VS.Kowane ml na 1 N sodium hydroxide yayi daidai da 64.03 MG na C6H8O7.
Sharuɗɗan karɓa: 99.5% -100.5% akan tushen anhydrous
RASHIN ZUCIYA
Najasa Na Inorganic
• Ragowa akan ƙonewa <281>: NMT 0.1%, ƙaddara akan 1.0 g
• Karfe masu nauyi <231>: NMT 10 ppm
• Sulfate
Daidaitaccen maganin sulfate A: 1.81 mg/mL na potassium sulfate a cikin 30% barasa.Nan da nan kafin amfani, canja wurin 10.0 ml na wannan maganin zuwa kwalban 1000-mL mai girma, tsoma tare da 30% barasa zuwa ƙara, da haɗuwa.Wannan bayani ya ƙunshi 10 μg/ml na sulfate.
Daidaitaccen maganin sulfate B: 1.81 mg/mL na potassium sulfate a cikin ruwa.Nan da nan kafin amfani da shi, canja wurin 10.0 ml na wannan maganin zuwa 1000-mL flask volumetric, tsarma da ruwa zuwa girma, da kuma haɗuwa.Wannan bayani ya ƙunshi 10 μg/ml na sulfate.
Maganin samfurin samfurin: 66.7 mg/mL na citric acid
Maganin samfurin: Zuwa 4.5 ml na daidaitaccen maganin sulfate A, ƙara 3 ml na maganin barium chloride (1 a cikin 4), girgiza, kuma ba da izinin tsayawa na 1 min.Zuwa 2.5 ml na sakamakon dakatarwa, ƙara 15 ml na Maganin Samfurin da 0.5 ml na 5 N acetic acid, da kuma haɗuwa.
Daidaitaccen bayani: Shirya kamar yadda aka umarce shi don maganin Samfurin, sai dai amfani da 15 ml na Standard sulfate solution B maimakon Samfurin bayani.
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Sharuɗɗan karɓa: Duk wani turbidity da aka samar a cikin Samfurin bayani bayan 5 min yana tsaye bai fi wanda aka samar a cikin daidaitaccen bayani (0.015%) ba.
Iyakar Aluminum (inda aka yi masa lakabi kamar yadda aka yi niyya don amfani da shi a cikin dialysis)
Daidaitaccen bayani na aluminum: zuwa 352 MG na aluminum potassium sulfate a cikin 100-mL volumetric flask, ƙara 'yan ml na ruwa, juyawa don narkewa, ƙara 10 ml na sulfuric acid diluted, tsarma da ruwa zuwa girma, da haɗuwa.Nan da nan kafin amfani, tsoma 1.0 ml na wannan maganin da ruwa zuwa 100.0 ml.
pH 6.0 acetate buffer: Narke 50 g na ammonium acetate a cikin 150 ml na ruwa, daidaita tare da glacial acetic acid zuwa pH na 6.0, tsarma da ruwa zuwa 250 ml, da Mix.
Daidaitaccen bayani: Shirya cakuda 2.0 ml na daidaitaccen bayani na aluminum, 10 ml na pH 6.0 acetate buffer, da 98 ml na ruwa.Cire wannan cakuda kamar yadda aka kwatanta don maganin Samfurin, tsoma abubuwan da aka haɗe tare da chloroform zuwa girma, da haɗuwa.
Maganin samfurin: Narke 20.0 g na Anhydrous Citric Acid a cikin 100 ml na ruwa, kuma ƙara 10 ml na pH 6.0 acetate buffer.Cire wannan maganin tare da rabo mai zuwa na 20, 20, da 10 ml na 0.5% na maganin 8-hydroxyquinoline a cikin chloroform, haɗa abubuwan chloroform a cikin filaye na 50-mL.Tsarma abubuwan da aka haɗe tare da chloroform zuwa ƙarar, da haɗuwa.
Maganin Blank: Shirya cakuda 10 ml na pH 6.0 acetate buffer da 100 ml na ruwa.Cire wannan cakuda kamar yadda aka bayyana don Samfurin bayani, tsoma abin da aka haɗe tare da chloroform zuwa ƙarar, da haɗuwa.
Yanayin fluorometric
Tsawon tashin hankali: 392 nm
Tsawon iska: 518 nm
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Ƙayyade ƙarfin haske na Samfuran a cikin saitin fluorometer kamar yadda aka umarce shi a ƙarƙashin yanayin Fluorometric, ta amfani da Maganin Blank don saita kayan aikin zuwa sifili.
Sharuɗɗan karɓa: Hasken haske na Maganin Samfurin bai wuce na daidaitaccen bayani ba (0.2 ppm).
Najasa Na Halitta
• Tsari: Iyakar Oxalic Acid
Maganin samfurin samfurin: 200 mg/mL na Citric Acid Anhydrous a cikin ruwa
Maganin samfurin: Zuwa 4 ml na samfurin samfurin samfurin ƙara 3 ml na hydrochloric acid da 1 g na zinc granular, tafasa don 1 min, kuma ba da damar tsayawa na 2 min.Canja wurin supernatant zuwa bututu mai ɗauke da 0.25 ml na maganin phenylhydrazine hydrochloride (1 cikin 100), da zafi zuwa tafasa.Yi sanyi da sauri, canja wurin zuwa silinda da aka kammala, kuma ƙara daidai adadin hydrochloric acid da 0.25 ml na maganin potassium ferricyanide (1 cikin 20).girgiza, kuma ba da izinin tsayawa na minti 30.
Daidaitaccen bayani: Shirya kamar yadda aka umurce shi don samfurin samfurin, sai dai amfani da 4 ml na 0.10 mg/mL oxalic acid bayani, daidai da 0.0714 mg/mL na oxalic acid anhydrous, maimakon samfurin samfurin samfurin.[Lura-Shirya tare tare da Maganin Samfurin.]
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Sharuɗɗan karɓa: Duk wani launin ruwan hoda da aka samar a cikin Samfurin bayani bai fi tsanani fiye da wanda aka samar a cikin daidaitaccen bayani (0.036%).
MAKAMMAN JARRABAWA
• Gwajin Endotoxins na Bacterial 85: Matsayin endotoxins na kwayan cuta shine abin da ake buƙata a cikin nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in ƙwayar cuta wanda ake amfani da Citric Acid Anhydrous.Inda lakabin jihohin cewa dole ne a inganta citric acid don cigaba yayin shiri na kayan masarufi (s) wanda ake buƙata a cikin ƙwayar ƙwayar ƙwayar cuta (s) wanda ake amfani da shi a cikin ƙwayar ƙwayar ƙwayar ƙwayar cuta (wacce ake amfani da citric acid din hadu.
• Bayyanar Magani
[Lura-Maganin Samfurin shine za a kwatanta shi da daidaitaccen dakatarwa A cikin hasken rana 5 min da aka watsar bayan shirya daidaitaccen dakatarwar A.]
Maganin hydrazine sulfate: 10 mg / ml na hydrazine sulfate a cikin ruwa.Bada damar tsayawa na awa 4 zuwa 6 kafin amfani.
Maganin Methenamine: Canja wurin 2.5 g na methenamine zuwa gilashin gilashin 100-mL, ƙara 25.0 ml na ruwa, saka gilashin gilashin, da haɗuwa don narke.
Dakatarwar opalescent na farko: Canja wurin 25.0 ml na maganin Hydrazine sulfate zuwa 25.0 ml na maganin Methenamine a cikin gilashin 100-mL mai tsayayye.Mix, kuma ba da izinin tsayawa na awa 24.[Lura-Wannan dakatarwar ta tsaya tsayin daka na tsawon watanni 2, idan har an adana ta a cikin kwandon gilashin da ba ta da lahani.Dakatarwar kada ta manne da gilashin kuma dole ne a hade sosai kafin amfani.]
Matsakaicin kyawawa: Tsarma 15.0 ml na dakatarwar opalescent na Farko da ruwa zuwa 1000 ml.[Lura-Kada a yi amfani da wannan dakatarwar fiye da sa'o'i 24 bayan shiri.]
Madaidaicin dakatarwa A: Tsarma 5.0 ml na daidaitaccen Opalescence tare da ruwa zuwa 100 ml.
Madaidaicin dakatarwa B: Tsarma 10.0 ml na daidaitaccen Opalescence da ruwa zuwa 100 ml.
Maganin samfurin: 200 mg/mL na Citric Acid Anhydrous a cikin ruwa
Bincike
Samfura: Daidaitaccen dakatarwa A, daidaitaccen dakatarwa B, ruwa, da Samfurin bayani
Canja wurin isasshen yanki na Maganin Samfurin zuwa bututun gwaji mara launi, m, gilashin tsaka tsaki tare da tushe mai lebur da diamita na ciki na 15-25 mm don samun zurfin 40 mm.Hakazalika canja wurin sassan daidaitaccen dakatarwa A, daidaitaccen dakatarwa B, da ruwa don raba bututun gwaji masu dacewa.Kwatanta Maganin Samfurin, Daidaitaccen dakatarwa A, daidaitaccen dakatarwa B, da ruwa a cikin hasken rana mai yaɗuwa, kallo a tsaye da bangon baƙar fata (duba Spectrophotometry da Haske- Watsawa 851, Kwatanta Kayayyakin gani).[Lura-Bayanin haske dole ne ya zama irin wannan daidaitaccen dakatarwar A za a iya bambanta shi da sauri daga ruwa, kuma za a iya bambanta Madaidaicin dakatarwar B daga daidaitaccen dakatarwar A.]
Sharuɗɗan karɓa: Maganin samfurin yana nuna tsabta iri ɗaya da na ruwa.
• Launi na Magani
Daidaitaccen bayani na samfurin A: Ferric chloride CS, cobaltous chloride CS, da dilute hydrochloric acid (10 g/L) (2.4:0.6:7.0)
Daidaitaccen bayani na hannun jari B: Ferric chloride CS, cobaltous chloride CS, cupric sulfate CS, da dilute hydrochloric acid (10 g/L) (2.4:1.0:0.4:6.2)
Daidaitaccen bayani na hannun jari C: Ferric chloride CS, cobaltous chloride CS, da cupric sulfate CS (9.6:0.2:0.2)
[Lura-Shirya Madaidaicin mafita nan da nan kafin amfani.]
Daidaitaccen bayani A: Tsarma 2.5 ml na daidaitaccen bayani na samfurin A tare da tsarma hydrochloric acid (10 g/L) zuwa 100 ml.
Daidaitaccen Maganin B: Tsarma 2.5 ml na daidaitaccen bayani na hannun jari B tare da tsarma hydrochloric acid zuwa (10 g/L) 100 ml.
Daidaitaccen Magani C: Tsarma 0.75 ml na daidaitaccen bayani na C tare da tsarma hydrochloric acid (10 g/L) zuwa 100 ml.
Maganin samfurin: Yi amfani da samfurin samfurin da aka shirya kamar yadda aka umarce shi a gwajin don Tsallake Magani.
Bincike
Misalai: Maganin daidaitaccen A, Daidaitaccen Maganin B, Daidaitaccen Maganin C, Ruwa, da Samfurin bayani
Canja wurin isasshen yanki na Maganin Samfurin zuwa bututun gwaji mara launi, m, gilashin tsaka tsaki tare da tushe mai lebur da diamita na ciki na 15-25 mm don samun zurfin 40 mm.Hakazalika canja wurin sassan daidaitaccen bayani A, Madaidaicin bayani B, daidaitaccen bayani C, da ruwa don raba bututun gwaji masu dacewa.Kwatanta Maganin Samfurin, Daidaitaccen Magani A, Daidaitaccen Magani B, Daidaitaccen Maganin C, da ruwa a cikin hasken rana mai yaɗuwa, kallo a tsaye da farar bango (duba Spectrophotometry da Haske-Watsawa 851, Kwatanta Kayayyakin gani).
Sharuɗɗan karɓa: Maganin samfurin bai fi tsananin launi ba fiye da daidaitaccen bayani A, B, ko C, ko ruwa.
• Abubuwan Carbonizable Shirye-shiryen
Misali: 1.0 g na powdered Anhydrous Citric Acid
Analysis: Canja wurin Samfurin zuwa bututun gwaji na 22- × 175-mm a baya an wanke shi tare da 10 ml na sulfuric acid kuma a bar shi ya zubar na minti 10.Ƙara 10 ml na sulfuric acid, tayar da hankali har sai bayani ya cika, da kuma nutsewa a cikin wanka na ruwa a 90 ± 1 don 60 ± 0.5 min, kiyaye matakin acid a ƙasa da matakin ruwa a duk tsawon lokacin.Sanya bututu a cikin ruwan gudu, kuma canja wurin acid zuwa bututu mai kwatanta launi.
Sharuɗɗan karɓa: Launin acid ɗin bai fi duhu fiye da na nau'in nau'in nau'in nau'in Matching Fluid K (duba Launi da Achromicity 631) a cikin bututu mai dacewa, ana lura da bututun a tsaye a kan wani farin bango.
• Gwajin Haihuwa 71: Inda alamar ta bayyana cewa Citric Acid Anhydrous ba ta da lafiya, ta cika buƙatun Gwajin Rashin Haihuwa 71 a cikin sigar da ta dace da monograph(s) wacce ake amfani da Anhydrous Citric Acid.
• Ƙaddamar da Ruwa, Hanyar I 921: NMT 1.0%
KARIN BUKATA
• Marufi da Ajiya: Ajiye a cikin matsuguni.Babu takamaiman buƙatun ajiya.
• Lakabi: Inda aka yi nufin amfani da shi wajen maganin dialysis, ana yi masa lakabi da haka.Inda Anhydrous Citric Acid dole ne a ƙaddamar da ƙarin sarrafawa yayin shirye-shiryen nau'ikan alluran allura don tabbatar da matakan yarda da ƙwayoyin endotoxins na kwayan cuta, ana sanyawa alama.Inda Anhydrous Citric Acid ya kasance bakararre, ana yi masa lakabi da haka.
• Matsayin Magana na USP 11
USP Citric Acid RS Danna don Duba Tsarin
USP Endotoxin RS