D- (+) Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na D- (+) - Cycloserine (CAS: 68-41-7) tare da babban inganci.Ruifu Chemical na iya samar da isar da sako na duniya, farashi mai gasa, ƙanana da yawa da ake samu.Sayi D-(+) - Cycloserine,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | D (+) - Cycloserine |
| Makamantu | D-Cycloserine;(+) - Cycloserine;(R) (+) - Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Matsayin Hannun jari | A Stock |
| Lambar CAS | 68-41-7 |
| Tsarin kwayoyin halitta | Saukewa: C3H6N2O2 |
| Nauyin Kwayoyin Halitta | 102.09 g/mol |
| Matsayin narkewa | 137 ℃ |
| M | Hankalin iska, Mai jin zafi |
| Solubility | Mai narkewa a cikin Ruwa.Dan Soluble a cikin Methanol da Propylene Glycol.Ba a iya narkewa a cikin chloroform da ether. |
| Adana Yanayin. | Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃) |
| COA & MSDS | Akwai |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Fari ko Kodadde Yellowish Crystalline Foda | Ya bi |
| Takamaiman Juyawa [α] 20/D | +108.0° zuwa +114.0° (C=5, 2N NaOH) | + 111.9 ° |
| Ganewa | Launi mai shuɗi ya Haɓaka A hankali | Launi mai shuɗi |
| Samfuran Namiji | ≤0.80% (a 286nm) | 0.08% |
| Asara akan bushewa | <1.00% | 0.38% |
| Ragowa akan Ignition | <0.50% | 0.10% |
| Karfe masu nauyi (Pb) | ≤10ppm | <10ppm |
| Rashin Mutuwar Karɓa | ||
| - methanol | ≤500ppm | <500ppm |
| - acetone | ≤500ppm | <500ppm |
| Assay (Antibiotic-Asayen Kwayoyin cuta) | ≥900μg/mg | 938mg/mg |
| pH | 5.5 zuwa 6.5 | 5.98 |
| FTIR | Ya dace | Ya dace |
| IR Spectrum | Ya dace | Ya dace |
| Farashin NMR Spectrum | Ya dace | Ya dace |
| Kammalawa | Wannan samfurin ta hanyar dubawa ya dace da daidaitattun USP-35 | |
Cycloserine [68-41-7].
Cycloserine yana da karfin da bai wuce 900µg na C3H6N2O2 a kowace MG ba.
Marufi da ajiya-Ajiye a cikin matsuguni.
Matsayin Magana na USP <11>-
USP Cycloserine RS
Ganewa-Narke kusan MG 1 a cikin 10 ml na 0.1 N sodium hydroxide.Zuwa 1 ml na maganin da aka samu ƙara 3 ml na 1 N acetic acid da 1 ml na cakuda, an shirya awa 1 kafin amfani, na daidai sassan sodium nitroprusside bayani (1 a cikin 25) da 4 N sodium hydroxide: launin shuɗi a hankali. tasowa.
Samfuran naɗaɗɗen-ƙarfinsa (duba Spectrophotometry da Haske-Watsawa <851>) a 285 nm, ƙaddara a cikin 0.1 N sodium hydroxide bayani mai dauke da 0.40 mg a kowace ml bai wuce 0.80 ba.
Takamaiman juyawa <781S>: tsakanin 108° da 114°.Maganin gwaji: 50 MG kowace ml, a cikin 2 N sodium hydroxide.
Crystallinity <695>: ya dace da buƙatun
pH <791>: tsakanin 5.5 da 6.5, a cikin wani bayani (1 a 10).
Asarar bushewa <731> - bushe game da 100 MG a cikin kwalban capillar y-stoppered a cikin injin ruwa a 60 ℃ na sa'o'i 3: yana rasa fiye da 1.0% na nauyinsa.
Ragowa akan kunnawa <281>: bai wuce 0.5% ba, ana ɗanɗano ragowar da aka ƙone tare da 2 ml na nitric acid da digo 5 na sulfuric acid.
Assay-
pH 6.8 Phosphate buffer-Shirya kamar yadda aka umarce shi a Matsalolin Buffer ƙarƙashin Magani a cikin sashe Reagents, Manuniya, da Magani.
Wayar hannu lokaci-Narke 0.5 g na sodium 1-decanesulfonate a cikin 800 ml na ruwa, ƙara 50 ml na acetonitrile da 5 ml na glacial acetic acid, da Mix.Daidaita tare da 1 N sodium hydroxide zuwa pH na 4.4.Tace, kuma dagas.Yi gyare-gyare idan ya cancanta y (duba Dacewar Tsarin ƙarƙashin Chromatography <621>).
Daidaitaccen shiri-Yawan narkar da adadin USP Cycloserine RS daidai gwargwado a cikin buffer pH 6.8 Phosphate don samun maganin da yake da sananniya na kusan 0.4 MG kowace ml.
Shirye-shiryen Assay-Canja wurin kusan 20 MG na Cycloserine, daidaitaccen auna, zuwa filasta na 50-mL, narke a ciki kuma a tsarma da pH 6.8 Phosphate buffer zuwa girma, da haɗuwa.
Tsarin Chromatographic (duba Chromatography <621>) -Chromatograph na ruwa yana sanye da na'urar ganowa 219-nm da ginshiƙin 4.6-mm × 25-cm wanda ya ƙunshi 5-µm tattara L1.Matsakaicin kwarara shine kusan 1 ml a minti daya.Ana kiyaye zafin ginshiƙi a kusan 30°.Chromatograph da Daidaitaccen shiri, da rikodin mafi girman martani kamar yadda aka ba da umarni don Tsari: ma'aunin wutsiya bai wuce 1.8 ba;kuma madaidaicin ma'auni na dangi don kwafin injections bai wuce 2.0%.
Tsari-Na dabam allura daidai juzu'i (kimanin 10 µL) na daidaitaccen shiri da shirye-shiryen Assay a cikin chromatograph, yin rikodin chromatograms, da auna mafi girman martani ga cycloserine.Yi ƙididdige adadin, a cikin µg, na C3H6N2O2 a cikin kowane MG na Cycloserine da aka ɗauka ta dabara:
50,000 (C/W)(rU/rS)
wanda C shine maida hankali, a cikin MG da ml, na USP Cycloserine RS a cikin Shirye-shiryen Standard;W shine adadin, a cikin MG, na Cycloserine da aka ɗauka don shirya shirye-shiryen Assay;da rU da rS sune kololuwar martani ga cycloserine da aka samu daga shirye-shiryen Assay da Daidaitaccen shiri, bi da bi.
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wurin sanyi da bushe (2 ~ 8 ℃) nesa da abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Bayarwa ga duniya ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Haɗin Kan Al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
Alamomin haɗari Xn - Cuta
Lambobin haɗari
R5 - Dumama na iya haifar da fashewa
R20 - Yana cutar da numfashi
Bayanin Tsaro
S38 - Idan akwai rashin isashshen iska, sanya kayan aikin numfashi masu dacewa.
S36/37 - Sanya tufafin kariya da safar hannu masu dacewa.
S24/25 - Guji hulɗa da fata da idanu.
WGK Jamus 2
Farashin NY2975000
FLUKA BRAND F CODES 10-23
Lambar 2941909099
D- (+) - Cycloserine (CAS: 68-41-7) yana da yanayin hygroscopic mai ƙarfi, yana narkewa cikin ruwa, mai narkewa a cikin ƙananan barasa, acetone da dioxane, kuma da wuya mai narkewa a cikin chloroform da ether petroleum.Yana da ingantacciyar kwanciyar hankali a cikin maganin alkaline kuma yana raguwa cikin sauri a cikin maganin acidic ko tsaka tsaki.A matsayin maganin rigakafi mai fadi, cycloserine yana hanawa da yawancin kwayoyin cutar Gram-positive da Gram-korau, rickettsia da wasu protozoa, ban da tarin fuka na Mycobacterium. Vinactane para-aminosalicylic acid, isoniazid da pyrazinamide.Cycloserine dan kadan yana aiki tare da isoniazid a cikin hana Mycobacterium tarin fuka H37RV, amma ba ya haɗawa kuma baya adawa da streptomycin.Samfurin wakili ne na bacteriostatic, don haka ba zai haifar da sakamako na bactericidal ba ko da lokacin ƙara yawan kashi ko tsawaita lokacin aiki tare da ƙwayoyin cuta.
Tsarin aikin D-cycloserine na antibacterial shine hana biosynthesis na peptidoglycan na bangon tantanin halitta.Kamar yadda shi ne tsarin analog na D-alanine, D-cycloserine na iya hana ayyukan alanine racemase da D-alanyl-D-alanine synthetase, waɗanda mahimman enzymes biyu ne a cikin haɗin peptidoglycan.D-cycloserine yana nuna rauni mai hanawa akan cutar ta Mycobacterium wanda shine kawai 1/10 zuwa 1/20 na streptomycin.Amfanin samfurin shine cewa yana da tasiri akan nau'ikan tarin fuka na Mycobacterium mai jurewa da kuma ƙarancin yuwuwar haifar da juriya na ƙwayoyi.Ana iya amfani da samfurin tare da wasu magungunan rigakafin tarin fuka a cikin maganin tarin fuka wanda cutar tarin fuka ta Mycobacterium mai jurewa magani.
Cycloserine maganin tarin fuka ne na layi na biyu.Yana iya hana ci gaban Mycobacterium tarin fuka, amma tasirin ya fi rauni fiye da na magungunan layi na farko.Ingancin sa a cikin maganin tarin fuka ya yi kadan.Amfani da miyagun ƙwayoyi kadai na iya haifar da juriya na ƙwayoyi, amma juriya yana faruwa a hankali idan aka kwatanta da na sauran magungunan maganin tarin fuka.Ba a sami juriya ba tsakanin cycloserine da sauran magungunan rigakafin tarin fuka.Hanyar aikin maganin kashe kwayoyin cuta shine don hana haɗin peptidoglycan na bangon ƙwayoyin cuta, yana haifar da lahani a cikin gine-ginen bangon sel.Babban tsarin tsarin bangon kwayar cutar shine peptidoglycan, wanda ya ƙunshi N-acetylglucosamine (GNAc) da N-acetylmuramic acid (MNAc).N-acetylmuramic acid yana da alaƙa da pentapeptide kuma yana haɗa N-acetylglucosamine ta hanyar maimaitawa da madadin.Samuwar cytoplasmic peptidoglycan precursor na iya zama cikas ta hanyar cycloserine, kamar yadda na ƙarshe zai iya hana tseren tseren da synthetase na D-Alanine, don haka yana toshe samuwar N-acetylmuramic acid.
D-Cycloserine za a iya samu ta hanyar fermentation dabara ko ta hanyar kai tsaye kira.Kwayoyin da ake amfani da su a cikin fermentation shine Actinomyces laven-dulae.Matsakaicin fermentation ya ƙunshi dextrin, dextrose, sitaci, foda waken soya, foda yisti, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate da man waken soya.A cikin tsarin haɗin gwiwar, ana samun D-Cycloserine daga β-Aminooxy alanine ethyl ester hydrochloride ta hanyar amsawa tare da potassium hydroxide a cikin motsi na cyclization.
