Dantrolene Sodium Gishiri Gishiri CAS 14663-23-1 API Babban Inganci
Ƙarfafawa tare da Babban Tsafta da Ƙarfin Ƙarfi
Sunan Sinadari: Dantrolene Sodium Gishiri Hydrate
Saukewa: 14663-23-1
Natsuwa da tsokar kwarangwal.Calcium Channel Inhibitor
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Sunan Sinadari | Dantrolene Sodium Salt Hydrate |
Makamantu | 1-[5- (4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt Hydrate |
Lambar CAS | 14663-23-1 |
Lambar CAT | RF-API78 |
Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
Tsarin kwayoyin halitta | Saukewa: C14H11N4NaO5 |
Nauyin Kwayoyin Halitta | 338.25 |
Solubility | Mai narkewa a cikin DMSO |
Yanayin jigilar kaya | An aika Karkashin Zazzabin yanayi |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Yellowish-Orange zuwa Orange Crystalline Foda.Babu wata shaida a bayyane na gurɓata al'amuran waje |
Identification A | Abun IR (197K) |
Identity B | Lokacin riƙewa na babban kololuwa a cikin chromatogram na shirye-shiryen gwaji ya dace da abin da ke cikin chromatogram na daidaitaccen shiri, kamar yadda aka samu a cikin binciken. |
Gano C | Ya dace da buƙatun gwajin harshen wuta don Sodium (191) |
Identity D | Sashe na 1: An ƙirƙiri wani ƙuri'a, fari, hazo Sashe na 2: Hazo ba ya ɓacewa Sashe na 3: Hazo ya narke gaba ɗaya Sashe na 4: Ba a samu hazo ba |
Abubuwan Ruwa (na KF) | 14.5% ~ 17.0% |
Girman Barbashi | 90% kasa da 200um |
Assay | 90.0% ~ 96.0% na C14H10N405 akan tushen anhydrous |
Abubuwa masu alaƙa | (HPLC, Yanki%) |
Abubuwan da ke da alaƙa A | ≤0.15% |
Abubuwan da ke da alaƙa B | ≤0.50% |
Abubuwan da ke da alaƙa C | ≤0.30% |
Ragowar Magani | |
Ethanol | ≤2000ppm |
Methanol | ≤2000ppm |
Acetone | ≤2000ppm |
DMF | ≤620ppm |
Karfe masu nauyi | ≤10ppm |
Rayuwar Rayuwa | Shekaru 2 |
Matsayin Gwaji | Amurka Pharmacopoeia (USP) |
Amfani | Natsuwa da tsokar kwarangwal.Calcium Channel Inhibitor |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
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Dantrolene Sodium Salt Hydrate (CAS 14663-23-1), karamin mai hana kwayoyin cuta ne na mai karɓar mai karɓa na Ryanodine da mai hana tashar Calcium.Dantrolene Sodium Salt shine mai shakatawa na kwarangwal, wanda ke hana intracellular Ca 2 + saki daga sarcoplasmic reticulum.Blockade na Ca2 + saki daga sarcoendoplasmic reticulum, mai karfi da alaka da tashin hankali da raguwa na tsokoki, yana haifar da tasirin shakatawa na tsoka wanda ke da alaƙa da Dantrolene.Neurotoxicity da aka gabatar ta hanyar aikin glutamate mai faɗi yana da alaƙa da haɓakar wuce kima a cikin matakan cytoplasmic Ca2 +, kuma Dantrolene an nuna shi azaman wakili na neuroprotective akan haɓakar neurotrasmitter-induced excitotoxicity.Dantrolene, Sodium Salt shine mai hana RyR-1 da RyR-3.