Daptomycin CAS 103060-53-3 Tsarkake ≥95.0% API Babban Tsabta

Daptomycin (CAS: 103060-53-3) wani nau'i ne na maganin rigakafi na lipopeptide na cyclic tare da sabon tsari.Ana fitar da shi daga broth fermentation na Streptomyces.Kamfanin Eli Lilly ne ya gano shi a cikin 1980s, kuma ya sami nasarar haɓaka shi a cikin 1997 ta Cubist Pharmaceuticals.Ba wai kawai yana da sabon tsarin sinadarai ba har ma yana da yanayin aiki wanda ya bambanta da duk wani maganin rigakafi da aka yarda da shi a baya: yana hana tantanin halitta ta hanyar rushe jigilar amino acid ta hanyar membrane cell, ta haka ne toshe bangon tantanin halitta peptidoglycan biosynthesis da canza yanayin yanayin. cell membrane.Yana iya lalata aikin membrane na kwayan cuta ta fuskoki da yawa, kuma yana kashe ƙwayoyin cuta masu gram da sauri.Baya ga rawar da take takawa a kan mafi yawan kwayoyin cutar gram-positive na asibiti, mafi mahimmanci, Daptomycin yana da tasiri mai ƙarfi wajen magance keɓance nau'ikan da ke nuna alamun juriya ga methicillin, vancomycin da linezolid.Wannan dukiya tana da mahimmancin asibiti ga marasa lafiya da ke fama da kamuwa da cuta mai tsanani.A cikin Satumba 2003, Hukumar Abinci da Magunguna ta Amurka ta amince a karon farko cewa ana iya amfani da Daptomycin (CAS: 103060-53-3) don maganin cututtukan fata masu tsanani.A cikin Maris 2006, an amince da shi don magance cututtuka masu yaduwa.A cikin Janairu 2006, Hukumar Tarayyar Turai ta amince da ita don maganin wasu cututtuka masu rikitarwa na fata da taushi na ƙwayoyin cuta waɗanda kwayoyin gram-positive suka haifar.A ranar 6 ga Satumba, 2007, Cubist Pharmaceuticals ta sanar da cewa Tarayyar Turai ta amince da maganin kashe kwayoyin cuta, Cubicin don maganin endocarditis na zuciya na dama wanda cututtuka na Staphylococcus aureus ke haifar da cututtuka da cututtuka masu rikitarwa na fata da cututtuka masu laushi da Staphylococcus aureus ke haifar.