Darunavir CAS 206361-99-1 Tsabtace Tsabtace-HIV

Darunavir (sunan suna Prezista, wanda aka fi sani da TMC114) magani ne mai hana protease da ake amfani dashi don magance kamuwa da cutar HIV.Darunavir wani zaɓi ne na OARAC da aka ba da shawarar magani don jiyya-rashin hankali da ƙwarewar jiyya manya da matasa.Darunavir wani sabon nau'i ne na marasa peptide anti retroviral protease inhibitors a maganin AIDS.Kamfanin Johnson Pharmaceutical Iceland reshen Tibotec ne ya fara haɓaka shi.Yana daga cikin mafi girma na bioavailability a cikin masu hana protease 6 (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir da ABT378/r).Yana aiki ta hanyar toshe samuwar sabbin ƙwayoyin ƙwayoyin cuta waɗanda suka balaga daga saman ƙwayoyin ƙwayoyin cuta da ke hana ƙwayoyin cuta.Lokacin da aka yi amfani da samfurin na dogon lokaci, yawanci yana iya rage ƙwayar cutar HIV a cikin jini, ƙara yawan adadin CD4, rage yiwuwar kamuwa da cutar HIV, inganta yanayin rayuwa da kuma tsawaita rayuwa.Ya dace da manya waɗanda ke ɗauke da kwayar cutar HIV amma ba su da tasiri a kan amfani da magungunan rigakafin da ke akwai.Dole ne a haɗa miyagun ƙwayoyi tare da yin amfani da ƙananan allurai na ritonavir ko wasu magungunan antiretroviral, don inganta tasiri.Ayyukan antiviral a cikin vitro za a iya ƙididdige su ta hanyar yin tsayayya da ƙananan ƙwayoyin lymphocytes masu kamuwa da cuta da lymphocytes a cikin jini na gefe.