Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Factory

Alamomin haɗari Xn - Cuta
Lambobin haɗari 20 - Cutarwa ta hanyar shakar numfashi
Bayanin Tsaro 36 - Sanya tufafin kariya masu dacewa.
WGK Jamus 3

Desmopressin Acetate (CAS: 16789-98-3) wato, 1-cysteine ​​deamination da 8-D-arginine maimakon 8-l-arginine, wanda kuma aka sani da arginine vasopressin, shine tsarin tsarin analog na dabi'ar arginine vasopressin, wanda ya samo asali. vasopressin, tasirin sa na antidiuretic ya fi ƙarfi kuma yana dawwama fiye da vasopressin, amma babu tasirin vasoconstrictor, sakamako masu illa na miyagun ƙwayoyi, na asibiti don rashin aikin haifuwa ko cututtukan ƙwayar cuta, uremia, hanta cirrhosis da abubuwan da ba a sani ba waɗanda ke haifar da tsawan lokaci na zub da jini;Ana iya amfani da shi don sarrafawa da hana zubar jini yayin ƙananan tiyata;Ciwon sukari na tsakiya insipidus.A cikin kowane mutum, wannan samfurin zai ma samar da inganci a cikin marasa lafiya masu matsakaicin cututtukan tsarin urinary, sau da yawa marasa lafiya a cikin marasa lafiya da nau'in IIB von Willebrand cuta.
Ayyukan Pharmacological: Desmopressin Acetate ya ƙunshi desmopressin wanda ke da tsari mai kama da arginine vasopressin na asali.Yana da bambanci tsakanin arginine vasopressin, yafi ga rabin amino acid da D arginine don maye gurbin L Arginine.Wadannan canje-canjen tsarin suna tsawaita tsawon lokacin aikin kashi na asibiti na desmopressin ba tare da lahani na matsawa ba.Wasu nazarin sun nuna cewa tasirin anti-enuresis yana da mahimmanci, wanda zai iya kasancewa saboda karuwar matakan arginine vasopressin a cikin jinin yara da dare, sa'an nan kuma mayar da hankali ga fitsari, rage yawan fitsari da karfin jini, rage wuyansa da kuma rage karfin jini. ƙanƙancewa na detrusor.
Ingancin sa, sauƙin gudanarwa (intranasal), tsawon lokacin aiki, da rashin sakamako masu illa sun sa shi zaɓin zaɓi don maganin ciwon sukari na tsakiya.Hakanan za'a iya gudanar da shi ta hanyar intramuscularly ta hanyar travenously.An fi son yin allurar vasopressin da maganin antidiuretics na baki don amfani a cikin yara.Ana nuna kulawar polydipsia na wucin gadi da polyurias wanda ke da alaƙa da rauni zuwa, ko tiyata a cikin, yankin pituitary.
Amfani da Clinical: Desmopressin, a matsayin gishirin acetate, shine analog na roba na vasopressin wanda N m Cys ba shi da aikin α-amino (1-Deamino) kuma inda Arg8 yake a matsayin D-isomer (D-Arg8) , don haka acronym na kasuwanci DDAVP.Kasancewar D-Arg da rashin N-terminal amine a cikin tsarin desmopressin ya karu da rabin rayuwarsa kamar yadda yake samuwa don amfani da baki, parenteral, ko hanci.Ana amfani da duk waɗannan hanyoyin gudanarwa guda uku don hanawa ko sarrafa polydipsia (ƙishirwa mai yawa), polyuria, da rashin ruwa na marasa lafiya da insipidus na ciwon sukari wanda ya haifar da rashi na vasopressin.Har ila yau, an yarda da shi don maganin enuresis na nocturnal (bed-wetting), wanda aka yi imani da shi ya haifar da rashin daidaituwa na dare na yau da kullum a cikin matakan vasopressin.An san Desmopressin don haifar da karuwa a cikin nau'i biyu na plasma factor VIII (antihemophilic factor) da plasminogen activator.Don haka FDA ta Amurka ta amince da ita don amfani, iyaye da kuma hanci, don rage cututtukan jini na kwatsam ko rauni a cikin marasa lafiya da ke da hemophilia A da nau'in cutar Von Willebrand na I, muddin aikinsu na plasma factor VIII ya fi 5%.Stimate, feshin hanci da ake amfani da shi wajen kula da marasa lafiya masu fama da cutar haemophilia A da nau'in cutar Von Willebrand na I, shine ninki 15 na maida hankali na DDAVP na hanci;Ana amfani da na karshen wajen magance ciwon sukari insipidus.