Diflorasone Diacetate CAS 33564-31-7 Assay 97.0 ~ 103.0% Corticosteroid Factory

Diflorasone Diacetate [33564-31-7]
» Diflorasone Diacetate ya ƙunshi ƙasa da kashi 97.0 kuma bai wuce kashi 103.0 na C26H32F2O7 ba, ƙididdiga akan busasshen tushe.
Marufi da ajiya-Ajiye a cikin matsuguni.
Matsayin Magana na USP <11>-
USP Diflorasone Diacetate RS
Ganewa, Ciwon Infrared <197M>.
Takamaiman juyawa <781S>: tsakanin +58° da +68°.Maganin gwaji: 20 MG, wanda ba a bushe ba, kowace ml, a cikin chloroform.
Asarar bushewa <731> - bushe shi a cikin injin daskarewa a 60 ° kuma a matsa lamba wanda bai wuce 5 mm na mercury ba na awanni 16: yana rasa fiye da 0.5% na nauyinsa.
Ragowar wuta <281>: bai wuce 0.5% ba
Tsaftar Chromatographic-
Tsarin wayar hannu da tsarin Chromatographic-Shirya kamar yadda aka umarce shi a cikin Assay.
Maganin Gwaji-Narke daidai adadin Diflorasone Diacetate a cikin ruwa mai cikakken chloroform don samun maganin da ke da kusan 6 MG a kowace ml.
Tsari - Allurar ƙarar (kimanin 10 µL) na maganin gwajin a cikin chromatograph, yi rikodin chromatogram na tsawon lokaci daidai da sau 5 na lokacin riƙe babban kolo, kuma auna wuraren duk kololuwa.Ƙididdige adadin kowane ƙazanta a cikin ɓangaren Diflorasone Diacetate da aka ɗauka ta dabara:
100 (ri / rs)
a cikin wanne ri ne wurin kololuwar kowane kazanta;kuma rs shine jimillar wuraren dukkan kololuwa: ba a sami fiye da 1.0% na kowane datti ba;kuma ba fiye da 2.0% na jimlar ƙazanta ana samun su ba.
Assay-
Wayar hannu lokaci-Shirya wani bayani mai dauke da cakuda ruwa-cikakken n-butyl chloride, ruwa-cikakken methylene chloride, glacial acetic acid, da tetrahydrofuran (350:125:15:10).Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography <621>).
Maganin daidaitaccen ciki-Amfani da cikakken chloroform na ruwa, shirya maganin isoflupredone acetate mai ɗauke da kusan 0.04 MG kowace ml.
Daidaitaccen shiri-Narke daidai adadin USP Diflorasone Diacetate RS a cikin daidaitaccen bayani na ciki don samun maganin da yake da sananniya na kusan 33µg kowace ml.
Shirye-shiryen Assay-Canja wurin kusan 15 MG na Diflorasone Diacetate, auna daidai, zuwa flask mai girma na 500-mL.Ƙara daidaitaccen bayani na ciki zuwa ƙara, da haɗuwa.
Tsarin Chromatographic (duba Chromatography <621>) -Chrmatography na ruwa an sanye shi da na'urar ganowa na 254-nm da ginshiƙin 4.6-mm × 10-cm wanda ya ƙunshi 3-µm tattarawar L3.Matsakaicin kwarara shine kusan 2.5 ml a minti daya.Chromatograph da daidaitattun shirye-shiryen, da yin rikodin wuraren kololuwa kamar yadda aka umurce su don Tsari: ƙuduri, R, tsakanin ƙididdiga da daidaitattun ƙididdiga na ciki bai gaza 12 ba;kuma madaidaicin ma'auni na dangi don ba kasa da nau'ikan alluran kwafi guda hudu ba ya wuce 2.0%.
Tsari-Na dabam allura daidai juzu'i (kimanin 10 µL) na daidaitaccen shiri da shirye-shiryen Assay a cikin chromatograph, yi rikodin chromatograms, da auna wuraren don manyan kololuwa.Lokacin riƙe dangi shine kusan 1.0 don diflorasone diacetate da 2.4 don daidaitaccen ciki.Yi ƙididdige adadin, a cikin MG, na C 26H32F2O7 a cikin ɓangaren Diflorasone Diacetate da aka ɗauka ta dabara:
0.5C (RU / RS)
wanda C shine maida hankali, a cikin µg a kowace ml, na USP Diflorasone Diacetate RS a cikin Shirye-shiryen Daidaitawa;da RU da RS sune ma'auni na wurare masu girma don Diflorasone Diacetate da kuma daidaitattun wurare na ciki da aka samu daga shirye-shiryen Assay da kuma Shirye-shiryen Daidaitawa, bi da bi.