Erlotinib Hydrochloride CAS 183319-69-9 Tsarkake>99.0% (HPLC)

Erlotinib Hydrochloride (CAS: 183319-69-9) wani karamin kwayoyin halitta ne na epidermal girma factor receptor tyrosine kinase reversible inhibitor, ana amfani da yafi a cikin jiyya na gida ci gaba ko metastatic ba kananan cell huhu ciwon daji da kuma na biyu line ko uku magani magani. ciwon daji na pancreatic.An amince da Erlotinib Hydrochloride a watan Nuwamba, 2004, don maganin ci gaba ko ciwon daji na huhu mara ƙarami.Yana cikin aji ɗaya da Gefitinib, wani quinazoline da aka amince da shi don maganin ciwon daji na huhu, amma tare da ingantattun kaddarorin magunguna.Pfizer ya samo asali ne kuma haɓakawa ya fara aiki tare da haɗin gwiwar OSI, wanda ya ɗauki cikakken haƙƙin magani lokacin da Pfizer ya haɗu da Warner Lambert.Daga baya, Genentech/Roche sun shiga yarjejeniyar lasisi tare da OSI don haɓakawa da tallata maganin a cikin Amurka da Duniya baki ɗaya.Zaɓin mai karɓar haɓakar haɓakar epidermal (EGFR) - mai hana tyrosine kinase.Antineoplastic.Erlotinib Hydrochloride shine mai hana HER1/EGFR tare da IC50 na 2 nM.Erlotinib HCl yana samuwa a matsayin 25-, 100-, da 150-mg Allunan gudanarwa na gaba.