Flurbiprofen CAS 5104-49-4 Assay 99.0 ~ 100.5% (HPLC) Factory

Flurbiprofen
C15H13FO2 244.27
(±) -2- (2-Fluoro-4-biphenylyl) propionic acid [5104-49-4].
Flurbiprofen ya ƙunshi bai wuce kashi 99.0 ba kuma bai wuce kashi 100.5 na C15H13FO2 ba, wanda aka lissafta akan busasshen tushe.
Marufi da ajiya - Ajiye a cikin matsatsun kwantena.
Matsayin Magana na USP <11>-
USP Flurbiprofen RS
USP Flurbiprofen Abubuwan da ke da alaƙa A RS
2- (4-Biphenylyl) propionic acid.
C15H14O2 226.28
Ganewa-
A: Ciwon Infrared <197K>.
B: Abun Ultraviolet 197U-
Magani: 10 μg kowace ml.
Matsakaici: 0.1 N sodium hydroxide.
Matsakaicin haɓakawa a 247 nm shine kusan 0.8.
Matsakaicin narkewa <741>: tsakanin 114 da 117.
Asarar bushewa <731> - bushe shi a cikin injin a cikin 60 zuwa nauyi akai-akai: ya rasa fiye da 0.5% na nauyinsa.
Ragowa akan kunnawa <281>: bai wuce 0.1% ba.
Karfe masu nauyi, Hanyar II <231>: 0.001%.
Abubuwan da ke da alaƙa-
Diluent-Shirya cakuda ruwa da acetonitrile (11: 9).
Wayar hannu lokaci-Shirya wani tacewa da kuma gurɓataccen cakuda ruwa, acetonitrile, da glacial acetic acid (12:7:1).Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography <621>).
Madaidaicin bayani na hannun jari- Narkar da daidaitaccen adadin USP Flurbiprofen Mai alaƙa da Haɗin A RS a cikin Diluent don samun maganin yana da taro kusan 50 µg a kowace ml.
Maganin dacewa da tsarin-Pipet 2.0 ml na daidaitaccen bayani na hannun jari a cikin faifan volumetric 10-mL, ƙara kusan 20 MG na USP Flurbiprofen RS, tsarma da Diluent zuwa ƙara, da haɗuwa.
Daidaitaccen Magani-Canja wurin 2.0 ml na daidaitaccen bayani na hannun jari zuwa kwalabe na 10.0-mL, tsoma tare da Diluent zuwa girma, da haɗuwa.
Maganin gwaji-Shirya maganin Flurbiprofen a cikin Diluent mai ɗauke da 2.0 MG kowace ml.
Tsarin Chromatographic (duba Chromatography <621>) -Chrmatography na ruwa yana sanye da na'urar ganowa 254-nm da ginshiƙin 3.9-mm × 15-cm wanda ya ƙunshi 4-µm tattara L1.Matsakaicin kwarara shine kusan 1 ml a minti daya.Chromatograph da tsarin dacewa da tsarin, da kuma yin rikodin martanin kololuwa kamar yadda aka umurce su don Tsari: lokutan riƙewa na dangi kusan 0.9 ne na fili mai alaƙa da Flurbiprofen A da 1.0 don flurbiprofen;kuma madaidaicin ma'auni na dangi don kwafin injections bai wuce 1.0%.
Tsari-Na dabam allura daidai juzu'i (kimanin 20 µL) na daidaitaccen bayani da maganin Gwaji a cikin chromatograph, yi rikodin chromatograms, da auna wuraren manyan kololuwa.Yi lissafin adadin abubuwan da ke da alaƙa da flurbiprofen A a cikin ɓangaren Flurbiprofen da aka ɗauka ta dabara:
100 (CS / CU) (rU / rS)
wanda CS shine maida hankali, a cikin µg kowace ml, na USP Flurbiprofen Related Compound A RS a cikin Daidaitaccen bayani;CU shine maida hankali, a cikin µg kowace ml, na Flurbiprofen a cikin maganin gwajin;da rU da rS sune mafi girman martani ga fili mai alaƙa da flurbiprofen A da aka samu daga Maganin Gwaji da Daidaitaccen Magani, bi da bi: an sami fiye da 0.5% na fili mai alaƙa da flurbiprofen.Yi ƙididdige adadin kowane ƙazanta a cikin ɓangaren Flurbiprofen da aka ɗauka ta dabara:
100 (ri / rs)
a cikin abin da ri ne kololuwar amsa ga kowane kazanta da aka samu daga maganin gwajin;kuma rs shine jimlar martanin duk kololuwar da aka samu daga maganin gwajin: jimlar duk ƙazanta bai wuce 1.0% ba.
Assay-Dissolve game da 0.5 g na Flurbiprofen, daidai auna, a cikin 100 ml na barasa, a baya neutralized tare da 0.1 N sodium hydroxide VS zuwa phenolphthalein endpoint, ƙara phenolphthalein TS, da titrate tare da 0.1 N sodium hydroxide VS zuwa farkon bayyanar suma. launin ruwan hoda wanda ke dauwama don bai wuce daƙiƙa 30 ba.Kowane ml na 0.1 N sodium hydroxide yayi daidai da 24.43 MG na C15H13FO2.