Fmoc-Ile-OH CAS 71989-23-6 Fmoc-L-Isoleucine Tsarkake> 99.0% (HPLC) Factory

Fmoc-L-Isoleucine (Fmoc-Ile-OH) (CAS: 71989-23-6) asalin isoleucine ne, amino acid ne wanda bai dace ba da ake amfani dashi don peptidomimetics.Fmoc-L-isoleucine shine Nα-9-fluorenylmethoxycarbonyl-amino acid.9-fluorenylmethoxycarbonyl muhimmin rukuni ne na kariyar amino a cikin haɗin peptide.Saboda ƙungiyar kariya ce mai mahimmanci kuma tana da kwanciyar hankali ga yanayin da ake amfani da su don cire ƙungiyoyin karewa na gama gari, yana da muhimmiyar rawa a haɗakar polypeptide.Daidaitaccen toshe don haɗakar peptide mai ƙarfi na yau da kullun yana bin dabarun Fmoc.
Fmoc-amino acid, wanda aka yi amfani da shi a cikin kira na peptide, ana amfani dashi azaman tsaka-tsakin haɗin gwiwar kwayoyin halitta, matsakaicin magunguna, reagent biochemical ko reagent sinadarai.
Shiri L-Isoleucine (CAS: 73-32-5) 1.05g (0.008 mol) na m aka narkar da a 10% sodium carbonate bayani, L-isoleucine m ya isasshe narkar da ta hanyar motsawa.A 20 ~ 30 ℃, 9-fluorenylmethoxycarbonyl chloride (205g) narkar da a toluene (2 ~ 2.10) aka kara dropwise, 0.008 mol) bayani, Dropwise ƙara 30 ~ 60 minutes, karshen Bugu da kari, a 20 ~ 30 C stirring 1. ~ 8 hours, ƙara 30 ~ 200 ml na ruwa dilution, tare da n-butyl acetate (80 ml) wuce haddi 9-fluorenylmethoxycarbonyl chloride da aka cire da hakar, sakamakon ruwa lokaci da aka acidified tare da maida hankali hydrochloric acid zuwa PH = 0.5 ~ 3.5, sa'an nan. An fitar da shi tare da n-butyl acetate (80 ml), kuma sakamakon man da aka samu an wanke shi da ruwa don cire hydrochloric acid, lokacin man ya mayar da hankali don cire n-butyl acetate mai narkewa, fararen lu'ulu'u sun fadi, tacewa da bushe don ba da samfurin. Fmoc-L-Isoleucine 2.48g, yawan amfanin ƙasa 87.9%, Matsayin narkewa: 140.0 ~ 155.0 ℃.