Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Tsarkake> 99.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) tare da babban inganci.Ruifu Chemical yana ba da jerin amino acid.Za mu iya samar da isarwa a duniya, farashi mai gasa, ƙanana da yawa da ake samu.Sayi Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Sunan Sinadari | N-Fmoc-L-Leucine |
| Makamantu | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy) carbonyl] -L-Leucine;N- (9-Fluorenylmethoxycarbonyl) -L-Leucine |
| Matsayin Hannun jari | A Hannun jari, Ƙarfin Samarwa zuwa Ton a kowane wata |
| Lambar CAS | 35661-60-0 |
| Tsarin kwayoyin halitta | Saukewa: C21H23NO4 |
| Nauyin Kwayoyin Halitta | 353.42 g/mol |
| Matsayin narkewa | 153.0 zuwa 160.0 ℃ |
| Yawan yawa | 1.207± 0.06 g/cm3 |
| M | Hygroscopic |
| Solubility a cikin methanol | Kusan Gaskiya |
| Adana Yanayin. | Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃) |
| COA & MSDS | Akwai |
| Kashi | Fmoc-Acids |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Farin Foda | Farin Foda |
| Takamaiman Juyawa [α] 20/D | -25.0°±2.0° (C=1 a cikin DMF) | -24.6° |
| Matsayin narkewa | 153.0 zuwa 160.0 ℃ | 155.1 ℃ |
| TLC | ≥98.0% | >98.0% |
| Tsaftar gani | <0.30% D-Enantiomer | Ya bi |
| Bayyanar Magani | 0.3 gram a cikin 2ml DMF Bayyanar Magani | Ya bi |
| Gwajin Kaiser | <0.05% | <0.05% |
| Ruwa ta Karl Fischer | <0.50% | 0.12% |
| Asara akan bushewa | <0.50% (60℃, 2h) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | Ya bi |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Ya bi |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Ya bi |
| Fmoc-Ile-OH | <0.10% (HPLC) | Ya bi |
| Amino acid kyauta | <0.20% (GC) | Ya bi |
| Ethyl acetate | <0.50% (GC) | Ya bi |
| Tsarkake / Hanyar Bincike | > 99.0% (HPLC) | 99.85% |
| Mass Spectrum | Bisa ga Ma'auni | Ya bi |
| Farashin NMR Spectrum | Bisa ga Ma'auni | Ya bi |
| Kammalawa | An gwada samfurin kuma ya dace da ƙayyadaddun bayanai | |
Kunshin: Fluorinated Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wurin sanyi da bushe (2 ~ 8 ℃) nesa da abubuwan da ba su dace ba.Kare daga haske da danshi.
Hanyar dubawa
1. Bayyanar
-- Duban gani
2. Tsafta (HPLC)
2.1 Kayan aiki
Babban aikin chromatography ruwa, mai gano PDA.
Ma'aunin nazari na lantarki
2.2 Reagent
Acetonitrile (makin chromatographic), Trifluoroacetic acid (jin chromatographic)
2.3 Yanayi na chromatographic
2.3.1 Rukunin: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Tsawon Gano: INC220nm
Yawan gudu: 1.0ml/min
Girman samfurin: 10 μL (bayani)
Diluent: acetonitrile
Lokacin tattara bayanai:25.00min
2.4 Shirye-shiryen lokaci na wayar hannu
Wayar hannu lokaci A (0.1% trifluoroacetic acid ruwa): daidai sha 2.0ml trifluoroacetic acid, diluted da ruwa zuwa 2000ml, Mix da kyau, da kuma degassing;
Wayar hannu lokaci B (0.1% acetonitrile trifluoroacetic acid): daidai sha 2.0ml trifluoroacetic acid, diluted zuwa 2000ml tare da acetonitrile, hadawa da degassing;
Lokaci (min) A% B%
0.0090 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Shiri na samfurin bayani
Yi nauyi da narkar da samfurin 0.1g tare da acetonitrile kuma a tsarma zuwa 100ml, girgiza da kyau don amfani, ko taro iri ɗaya.Shirya samfurori guda biyu a layi daya.
2.7 Samfurin Ƙaddamarwa
Yi nazarin samfurin bisa ga tsarin samfur mai zuwa:
Fiye da allura 1 na bayani mara kyau
Maganin samfurin allura 1 1#
Maganin samfurin allura 1 2#
2.8 Kididdigar sakamako
2.8.1 An yi amfani da hanyar daidaita yanayin yanki mafi girma don ƙididdige tsaftar HPLC ta hanyar cire sarari mara kyau.
2.8.2 Ma'anar ma'anar ma'anar tsarkin allura biyu ba za ta fi 1% ba.
2.8.3 Idan sakamakon alluran biyu sun cika ka'idojin yarda, ana ɗaukar matsakaicin tsafta azaman sakamako na ƙarshe.
3, Matsayin narkewa -- RY-1 kayan aikin narkewa
4. Asarar hanyar gwajin bushewa
4.1 Kayan aiki:
Tanda mai bushewa mai zafi na lantarki, ma'auni 1/10,000.
4.2 Tsari:
A cikin kwalabe mai nauyi tare da madaidaicin nauyi da murfin bakin ƙasa mai bushewa, auna gram 1 (daidai zuwa gram 0.0001) na samfurin.Samfurin ya kamata a ko'ina yada a kasan kwalban auna tare da kauri na ba fiye da 10mm, sa a cikin wani thermostatic lantarki bushe tanda, bushe a 105 ~ 110 ℃ na 3 hours, sa'an nan kuma matsa zuwa cikin bushewa dakin don kwantar da hankali. zafin dakin don aunawa.
Lissafi: Asarar bushewa %= (M1-M2) ÷M×100
Inda: M1: nauyin samfurin da kwalban auna kafin bushewa, grams
M2: nauyin samfurin da kwalban aunawa bayan bushewa, a cikin grams
M: Nauyin samfurin, grams
5. Takamaiman juyawa
-- Ana auna takamaiman juyawa daidai da GB/T613-1988
Shirye-shiryen samfurin: 0.5000g samfurin an auna daidai kuma an motsa shi zuwa kwalban 50ml mai tsabta da bushe, 20ml DMF an kara shi, an rufe kwalban kuma girgiza don narke, sa'an nan kuma an diluted zuwa sikelin tare da DMF.
Gwaji: Daidaita sifilin gyroscope kafin gwajin, sannan ɗora bututun gwajin tare da maganin samfurin, yi rikodin kusurwar juyawa, kuma ƙididdige takamaiman juyawa na samfurin tare da dabara mai zuwa.
[a]D20=(r×50) ÷ (L×W)
[a] D20: Takamaiman juyawa na gani a 25 ℃ na maganin samfurin
r: Juyawa na gani da aka lura a 20 ℃ don maganin samfurin
50: Girman maganin samfurin da aka shirya (ml)
w: Misalin nauyi (g)
L: Tsawon bututun juyawa na gani (dm)
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.
Manyan Kasuwanni?Sayarwa zuwa kasuwannin cikin gida, Arewacin Amurka, Turai, Indiya, Koriya, Jafananci, Australia, da sauransu.
Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.
Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.
Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.
Haɗin Kan Al'ada?Zai iya ba da sabis na haɗawa na al'ada don dacewa da buƙatun bincikenku.
Sharuɗɗan Biyan kuɗi?Za a fara aiko da daftari na Proforma bayan tabbatar da oda, an rufe bayanan bankin mu.Biya ta T/T (Telex Transfer), PayPal, Western Union, da dai sauransu.
Alamomin haɗari Xi - Haushi
Lambobin haɗari 36/37/38 - Haɗa kai ga idanu, tsarin numfashi da fata.
Bayanin Tsaro S22 - Kar a shaka ƙura.
S24/25 - Guji hulɗa da fata da idanu.
S36/37/39 - Sanya tufafin kariya masu dacewa, safar hannu da kariya ta ido/ fuska.
S27 - Cire duk gurbatattun tufafi nan da nan.
S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita.
WGK Jamus 3
Lambar 2922491990
N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) wani nau'in amino acid ne wanda za'a iya shirya ta hanyar amsawar L-Leucine da 9-Fluorenomethoxycarbonyl Chloride.
Fmoc-amino acid, wanda aka yi amfani da shi a cikin kira na peptide, ana amfani dashi azaman tsaka-tsakin haɗin gwiwar kwayoyin halitta, matsakaicin magunguna, reagent biochemical ko reagent sinadarai.
Fmoc-L-Leu-OH, asalin amino acid ne, wanda ake amfani dashi a cikin sinadarai na peptide.Daidaitaccen toshe don haɗakar peptide mai ƙarfi na yau da kullun yana bin dabarun Fmoc.Har ila yau, ɗaya daga cikin novel PPARγ ligands wanda zai iya kunna PPARγ ta hanyoyi daban-daban, wanda ke rage bambancin osteoclasts, kuma don haka sun fi dacewa da maganin ciwon sukari fiye da magungunan antidiabetic na gargajiya.
Shiri 1.05g (0.008 mol) L-Leucine m yana narkar da a cikin 10% sodium carbonate bayani, zuga don cikakken narke glycine m, da 9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) bayani narkar da a toluene (2 ~ 205 ml) Ana ƙara dropwise a 20 ~ 30 ℃, sauke ƙari na minti 30 ~ 60, ƙare ƙarar juzu'i, motsawa a 20 ~ 30 ℃ na tsawon awanni 1 ~ 8, ƙara 30-200 ml na ruwa don tsarma, kuma a cire tare da n-butyl. acetate (80 ml) don cire wuce haddi 9-fluorene methoxycarbonyl chloride, The samu ruwa lokaci ne acidified tare da maida hankali hydrochloric acid zuwa PH = 0.5 ~ 3.5, sa'an nan kuma fitar da n-butyl acetate (80 ml), da kuma samu man lokaci ne. an wanke shi da ruwa don cire acid hydrochloric, lokacin mai ya mayar da hankali ne don cire n-butyl acetate solvent, fararen lu'ulu'u sun haɗe, tacewa da bushe don samun 2.46g na Nα-9-fluorene methoxycarbonyl-L-leucine, tare da yawan amfanin ƙasa na 87.0 %.
-
L-Arginine Hydrochloride CAS 1119-34-2 (H-Arg-O...
-
BOP-Cl CAS 68641-49-6 Peptide Coupling Reagent ...
-
Boc-L-Norvaline DCHA CAS 67861-96-5 Assay>98.0...
-
S-Methyl-L-Cysteine CAS 1187-84-4 H-Cys(Ni) -OH ...
-
O-Benzyl-L-Serinol Hydrochloride CAS 58577-87-0...
-
BOP Reagent CAS 56602-33-6 Peptide Coupling Rea...