Fondaparinux sodium CAS 114870-03-0 API
Ƙarfafawa tare da Babban Tsafta da Ƙarfin Ƙarfi
Sunan Chemical: Fondaparinux sodium
Saukewa: 114870-03
Antithrombotic Anticoagulant, Factor Xa Inhibitor
API High Quality, Kasuwancin Kasuwanci
Sunan Sinadari | Fondaparinux sodium |
Lambar CAS | 114870-03-0 |
Lambar CAT | RF-API84 |
Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
Tsarin kwayoyin halitta | C31H43N3O49S8.10Na |
Nauyin Kwayoyin Halitta | 1728.08 |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari zuwa Kashe-Farin Foda |
Hanyar Assay / Analysis | 95.0% ~ 103.0% (a busasshen tushe) |
Solubility | Soluble a cikin Ruwa, 2.0M Sodium Chloride da 0.5M Sodium Hydroxide da Insoluble a cikin Ethanol |
Bayanan Bayani na 13C-NMR | Ya kamata a lura da resonances na Fondaparinux Sodium a 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7mpp da 176.7mpp.Canje-canjen sinadarai na waɗannan sigina ba su bambanta da fiye da ± 0.3ppm sauran sigina na tsayi masu tsayi da canjin sinadarai, wanda aka danganta da Fondaparinux Sodium, wataƙila ana iya gani tsakanin 58.0 ~ 80.5 ppm da 98.7 ~ 104.5ppm |
Bayanin HPLC | Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na daidaitaccen bayani |
Bayanin AAS | Sodium yakamata ya sami halayen halayen halayen a 330.2nm ƙarƙashin ƙaddarar sodium |
pH | 6.0-8.0 |
Sodium (Na) | 11.5% ~ 15.0% (Lissafta akan anhydrous da kaushi kyauta) |
Sulfate kyauta | ≤0.30% |
Ragowar Chloride | ≤1.00% |
Abubuwa masu alaƙa | |
Najasa A | ≤0.80% |
Rashin tsarki B | ≤0.60% |
Daya Sauran Rashin Tsabta | ≤0.30% |
Jimlar ƙazanta | ≤2.00% |
Ragowar Magani | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Abubuwan Ruwa (KF) | ≤15.0% |
Bacterial Endotoxins | ≤3.3EU/mg |
Iyakar Microbial | Jimlar adadin ƙwayoyin cuta ≤100cfu/g |
Matsayin Gwaji | Matsayin Kasuwanci;Amurka Pharmacopoeia (USP) Standard |
Amfani | API, Antithrombotic Anticoagulant, Factor Xa Inhibitor |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
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Fondaparinux Sodium (CAS 114870-03-0) shine farkon sabon aji na antithrombotic anticoagulant sinadarai masu alaƙa da ƙananan nauyin heparins (LMWH).Fondaparinux sodium shine factor Xa inhibitor don samar da babban haɗin haɗin gwiwa don anti-coagulant factor antithrombin III (ATIII).Fondaparinux sodium dauri a wannan rukunin yanar gizon yana ƙarfafa tasirin hanawa na halitta na ATIII akan factor Xa ta hanyar kusan 300, wanda ke haifar da hana haɓakar thrombin.GlaxoSmithKline ne ke tallata shi.Wani nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i) wanda Alchemia ya haɓaka a cikin Amurka ta Dr. Reddy's Laboratories.Fondaparinux sodium an fara gabatar da shi a cikin Amurka don rigakafin thrombosis mai zurfi wanda zai iya haifar da kumburin huhu bayan babban tiyatar kasusuwa.Wannan kwayar halittar gaba daya ta roba kwafin jerin heparin pentasaccharide ne, mafi guntu guntu iya haifar da hanawar antithrombin lllmediated na factor Xa ta haka yana hana tsarawar thrombin ba tare da aikin antithrombin ba.
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