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N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Tsabtataccen Hoto
  • N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity

N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity

Takaitaccen Bayani:

Suna: N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea

Synonyms: Imatinib Mesylate Intermediate

Saukewa: 152460-1

Bayyanar: Hasken Orange zuwa Foda Jawo zuwa Crystal

Tsafta: ≥98.0% (HPLC)

Matsakaicin Imatinib Mesylate (CAS: 220127-57-1) a cikin jiyya na Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph+CML)

Inquiry: alvin@ruifuchem.com


Cikakken Bayani

Samfura masu dangantaka

Tags samfurin

Bayani:

Samar da Kasuwancin Imatinib Mesylate da Matsakaici masu alaƙa:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS: 106261-49-8

Abubuwan Sinadarai:

Sunan Sinadari N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea
Makamantu Imatinib Mesylate Intermediate;2- (5-Amino-2-methylanilino) -4- (3-pyridyl) pyrimidine
Lambar CAS 152460-10
Lambar CAT Saukewa: RF-PI230
Matsayin Hannun jari A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton
Tsarin kwayoyin halitta C16H15N5
Nauyin Kwayoyin Halitta 277.32
Matsayin narkewa 133.0-135.0 ℃
Alamar Ruifu Chemical

Ƙayyadaddun bayanai:

Abu Ƙayyadaddun bayanai
Bayyanar Orange Haske zuwa Foda Jawo zuwa Crystal
Tsarkake / Hanyar Bincike ≥98.0%
Asara akan bushewa ≤0.50%
Ragowa akan kunnawa ≤0.50%
Jimlar ƙazanta ≤2.0%
Matsakaicin Tsabtace Guda Daya ≤1.0%
Karfe masu nauyi ≤20ppm
Matsayin Gwaji Matsayin Kasuwanci
Amfani Matsakaicin Imatinib Mesylate (CAS: 220127-57-1)

Kunshin & Ajiya:

Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.

Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.

Amfani:

1

FAQ:

Aikace-aikace:

Shanghai Ruifu Chemical Co., Ltd. shine babban masana'anta kuma mai samar da N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) tare da babban inganci. .
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) matsakaici ne yawanci a cikin kirar Imatinib Mesylate (CAS: 220127-57-1) ) API.
Imatinib mesylate wani ƙananan ƙwayoyin cuta ne wanda ke hana c-Abl protein-tyrosine kinase, kinase mai mahimmanci musamman don yaduwar cutar sankarar jini na myelogenous (CML).Wani lamari mai canzawa tsakanin chromosomes 9 da 22 yana haifar da chromosome na Philadelphia, wanda sannan ya samar da furotin Bcr-Abl fusion tare da aikin kinase mai banƙyama wanda ke inganta yaduwar kwayar halitta.Imatinib mesylate yana ɗaure wannan mahimmancin kinase, yana dakatar da haɓakar CML.An ƙara nuna Imatinib mesylate don hana PDGFR da tyrosine kinases masu alaƙa da c-Kit.An yi amfani da nau'ikan da ke ɗauke da Imatinib mesylate don magance cututtukan daji daban-daban.
Imatinib mesylate shine mai hana tyrosine kinase.Musamman musamman ga BCR-ABL, enzyme da ke hade da cutar sankarar myelogenous na yau da kullun (CML) da wasu nau'ikan cutar sankarar lymphoblastic mai tsanani (ALL).V-Abl tyrosine kinase inhibitor ne mai ƙarfi da zaɓi (IC50 = 38 nM).Hakanan yana hana PDGFR da c-kit.Yana nuna zaɓi don v-Abl akan rukunin sauran tyrosine da serine/threonine protein kinases.Zaɓin ya hana PDGF-ƙarfafa haɓakar ƙwayoyin PB-3 da aka canza v-abl da sel BALB/c 3T3 da aka canza a cikin vitro.Yana nuna tasirin antitumor a cikin beraye masu ɗauke da AMuLV ko sel BABL/c 3T3 v-sis.Yana hana kwafin SARS-CoV da MERS-CoV a cikin vitro (ƙimar EC50 sune 9.823 da 17.689 μM, bi da bi).

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