Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API High Quality Factory
Samar da Kasuwancin Imatinib Mesylate da Matsakaici masu alaƙa:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS: 106261-49-8
| Sunan Sinadari | Imatinib Mesylate (alpha form) |
| Makamantu | Imatinib Methanesulfonate;STI571 Mesylate;Saukewa: CGP-57148B |
| Lambar CAS | 220127-57-1 |
| Lambar CAT | RF-API19 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C30H35N7O4S |
| Nauyin Kwayoyin Halitta | 589.71 |
| Yanayin jigilar kaya | Karkashin Zazzabi |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari zuwa Kashe-White Crystalline Foda |
| Solubility | Sauƙi don narke cikin ruwa |
| HPLC Identification | Samfurin bakan babban lokacin riƙewa ya dace da wannan |
| IR Identification | Infrared sha bakan samfurin ya dace da samfurin tunani |
| Matsayin narkewa | 214.0 ~ 222.0 ℃ |
| Asara akan bushewa | ≤0.50% |
| Ragowa akan Ignition | ≤0.10% |
| Karfe masu nauyi | ≤20ppm |
| Abubuwa masu alaƙa | (1) Rashin tsabta G: NMT 0.3% |
| (2) Najasa B: NMT 0.3% | |
| (3) Rashin tsarki C: NMT 0.3% | |
| (4) Rashin tsarki D: NMT 0.3% | |
| (5) Rashin tsarki A: NMT 0.3% | |
| (6) Najasa H: NMT 0.3% | |
| (7) Rashin tsabta F: NMT 0.3% | |
| (8) Rashin tsabta E: NMT 0.3% | |
| (9) Mafi girman ƙazanta guda ɗaya: NMT0.1% | |
| Ragowar Magani | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Farashin HPLC | 98.0% ~ 102.0% (C30H35N7SO4 An ƙididdige shi akan Tushen Anhydrous) |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | API;Ph+CML |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Imatinib Mesylate (CAS 220127-57-1) wani ƙananan ƙwayoyin cuta ne wanda ke hana c-Abl protein-tyrosine kinase, kinase mai mahimmanci don yaduwa na cutar sankarar jini na myelogenous (CML).Musamman musamman ga BCR-ABL, enzyme da ke hade da cutar sankarar myelogenous na yau da kullun (CML) da wasu nau'ikan cutar sankarar lymphoblastic mai tsanani (ALL).V-Abl tyrosine kinase inhibitor ne mai ƙarfi da zaɓi (IC50 = 38 nM).Wani lamari mai canzawa tsakanin chromosomes 9 da 22 yana haifar da chromosome na Philadelphia, wanda sannan ya samar da furotin Bcr-Abl fusion tare da aikin kinase mai banƙyama wanda ke inganta yaduwar kwayar halitta.Imatinib mesylate yana ɗaure wannan mahimmancin kinase, yana dakatar da haɓakar CML.An ƙara nuna Imatinib mesylate don hana PDGFR da tyrosine kinases masu alaƙa da c-Kit.
![4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)